N-phenyl-3,3-dimethyl4-hydroxy-benzoindoline

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-phenyl-3,3-dimethyl4-hydroxy-benzoindoline
• 英文别名: 3,3-dimethyl-1-phenyl-2H-benzo[g]indol-4-ol
• 化学式: C₂₀H₁₉NO
• 分子量: 289.4
• InChiKey: XSIKRUWQXMDIKM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1H,2H,3H-Benzo[G]indole 、 N-phenyl-3,3-dimethyl4-hydroxy-benzoindoline 、 trifluoromethanesulfonate 、 、 苯胺 在 钯 作用下， 以to give a secondary amine, e.g., 1-anilino-3-methoxynaphthalene 5的产率得到
  参考文献：
  名称：

  Sulfonated diarylrhodamine dyes

  摘要：

  磺化二芳基荧光素化合物可用作核苷酸，核苷酸，多核苷酸和多肽的荧光标记物。这些化合物在荧光核酸分析领域中具有特定的应用，例如自动DNA测序和片段分析，杂交阵列中探针杂交的检测，核酸扩增产物的检测等。

  公开号：

  US20040096397A1

文献信息

• Methods of labelling polynucleotides with dibenzorhodamine dyes
  申请人：Applera Corporation

  公开号：US20040072209A1

  公开（公告）日：2004-04-15

  Dibenzorhodamine compounds having the structure 1 are disclosed, including nitrogen- and aryl-substituted forms thereof. In addition, two intermediates useful for synthesizing such compounds are disclosed, a first intermediate having the structure 2 including nitrogen- and aryl-substituted forms thereof, and a second intermediate having the structure 3 including nitrogen- and aryl-substituted forms thereof, wherein substituents at positions C-14 to C18 taken separately are selected from the group consisting of hydrogen, chlorine, fluorine, lower alkyl, carboxylic acid, sulfonic acid, —CH 2 OH, alkoxy, phenoxy, linking group, and substituted forms thereof. The invention further includes energy transfer dyes comprising the dibenzorhodamine compounds, nucleosides labeled with the dibenzorhodamine compounds, and nucleic acid analysis methods employing the dibenzorhodamine compounds.

  本发明公开了具有结构1的二苯基罗丹明化合物，包括其氮代和芳基取代形式。此外，还公开了用于合成这种化合物的两种中间体，第一中间体具有结构2，包括其氮代和芳基取代形式，第二中间体具有结构3，包括其氮代和芳基取代形式，其中在C-14到C18位置的取代基单独选择自氢、氯、氟、低碳基、羧酸、磺酸、—CH2OH、烷氧基、苯氧基、连接基和其取代形式的群。本发明还包括包含二苯基罗丹明化合物的能量转移染料，使用二苯基罗丹明化合物标记的核苷酸和使用二苯基罗丹明化合物的核酸分析方法。
• Polynucleotides labeled with dibenzorhodamine dyes
  申请人：The Perkin-Elmer Corporation

  公开号：US20010011139A1

  公开（公告）日：2001-08-02

  Dibenzorhodamine compounds having the structure 1 are disclosed, including nitogen- and aryl-substituted forms thereof. In addition, two intermediates useful for synthesizing such compounds are disclosed, a first intermediate having the structure 2 including nitrogen- and aryl-substituted forms thereof, and a second intermediate having the structure 3 including nitrogen- and aryl-substituted forms thereof, wherein substituents at positions C-14 to C18 taken separately are selected from the group consisting of hydrogen, chlorine, fluorine, lower alkyl, carboxylic acid, sulfonic acid, —CH 2 OH, alkoxy, phenoxy, linking group, and substituted forms thereof. The invention further includes energy transfer dyes comprising the dibenzorhodamine compounds, nucleosides labeled with the dibenzorhodamine compounds, and nucleic acid analysis methods employing the dibenzorhodamine compounds.

  本文披露了具有结构1的二苯基罗丹明化合物，包括其氮和芳基取代形式。此外，还披露了两种用于合成这种化合物的中间体，第一种中间体具有结构2，包括其氮和芳基取代形式，第二种中间体具有结构3，包括其氮和芳基取代形式，其中单独取C-14到C18位置的取代基被选自羟基、氯、氟、低碳基、羧酸、磺酸、-CH2OH、烷氧基、苯氧基、连接基和其取代形式的群。本发明还包括包含二苯基罗丹明化合物的能量转移染料，用二苯基罗丹明化合物标记的核苷酸以及采用二苯基罗丹明化合物的核酸分析方法。
• Dibenzorhodamine dyes
  申请人：The Perkin-Elmer Corporation

  公开号：US06221606B1

  公开（公告）日：2001-04-24

  Dibenzorhodamine compounds having the structure are disclosed, including nitogen- and aryl-substituted forms thereof. In addition, two intermediates useful for synthesizing such compounds are disclosed, a first intermediate having the structure including nitrogen- and aryl-substituted forns thereof, and a second intermediate having the structure including nitrogen- and aryl-substituted forms thereof, wherein substituents at positions C-14 to C18 taken separately are selected from the group consisting of hydrogen, chlorine, fluorine, lower alky, carboxylic acid, sulfonic acid, —CH2OH, alkoxy, phenoxy, linking group, and substituted forms thereof. The invention further includes energy transfer dyes comprising the dibenzorhodamine compounds, nucleosides labeled with the dibenzorhodamine compounds, and nucleic acid analysis methods employing the dibenzorhodamine compounds.

  本发明揭示了具有以下结构的二苯基罗丹明化合物，包括其氮和芳基取代形式。此外，还揭示了用于合成这种化合物的两种中间体，第一中间体具有以下结构，包括其氮和芳基取代形式，第二中间体具有以下结构，包括其氮和芳基取代形式，其中在C-14到C18位置上的取代基单独选择自氢、氯、氟、低碳基、羧酸、磺酸、-CH2OH、烷氧基、苯氧基、连接基和其取代形式的群。本发明还包括包含二苯基罗丹明化合物的能量转移染料，用二苯基罗丹明化合物标记的核苷酸以及利用二苯基罗丹明化合物进行核酸分析的方法。
• Methods of Labelling Polynucleotides with Dibenzorhodamine Dyes
  申请人：Benson C. Scott

  公开号：US20070099210A1

  公开（公告）日：2007-05-03

  Dibenzorhodamine compounds having the structure are disclosed, including nitrogen- and aryl-substituted forms thereof. In addition, two intermediates useful for synthesizing such compounds are disclosed, a first intermediate having the structure including nitrogen- and aryl-substituted forms thereof, and a second intermediate having the structure including nitrogen- and aryl-substituted forms thereof, wherein substituents at positions C14 to C18 taken separately are selected from the group consisting of hydrogen, chlorine, fluorine, lower alkyl, carboxylic acid, sulfonic acid, —CH 2 OH, alkoxy, phenoxy, linking group, and substituted forms thereof. The invention further includes energy transfer dyes comprising the dibenzorhodamine compounds, nucleosides labeled with the dibenzorhodamine compounds, and nucleic acid analysis methods employing the dibenzorhodamine compounds.

  本发明涉及具有结构的二苯基罗丹明化合物，包括其氮和芳基取代形式。此外，还公开了两种合成此类化合物有用的中间体，第一种中间体具有结构，包括其氮和芳基取代形式，第二种中间体具有结构，包括其氮和芳基取代形式，其中C14到C18位置的取代基单独选择自氢、氯、氟、低烷基、羧酸、磺酸、-CH2OH、烷氧基、苯氧基、连接基和其取代形式的群。本发明还包括包含二苯基罗丹明化合物的能量转移染料，用二苯基罗丹明化合物标记的核苷酸以及使用二苯基罗丹明化合物的核酸分析方法。
• METHODS OF LABELING POLYNUCLEOTIDE WITH DIBENZORHODAMINE DYES
  申请人：BENSON Scott C.

  公开号：US20110124510A1

  公开（公告）日：2011-05-26

  Dibenzorhodamine compounds having the structure are disclosed, including nitrogen- and aryl-substituted forms thereof. In addition, two intermediates useful for synthesizing such compounds are disclosed, a first intermediate having the structure including nitrogen- and aryl-substituted forms thereof, and a second intermediate having the structure including nitrogen- and aryl-substituted forms thereof, wherein substituents at positions C-14 to C18 taken separately are selected from the group consisting of hydrogen, chlorine, fluorine, lower alkyl, carboxylic acid, sulfonic acid, —CH 2 OH, alkoxy, phenoxy, linking group, and substituted forms thereof. The invention further includes energy transfer dyes comprising the dibenzorhodamine compounds, nucleosides labeled with the dibenzorhodamine compounds, and nucleic acid analysis methods employing the dibenzorhodamine compounds.

  本发明公开了具有以下结构的二苯基罗丹明化合物，包括其氮基和芳基取代形式。此外，本发明还公开了用于合成此类化合物的两种中间体，第一种中间体具有以下结构，包括其氮基和芳基取代形式，第二种中间体具有以下结构，包括其氮基和芳基取代形式，其中单独取代C-14到C18位置的取代基选自氢、氯、氟、低碳基、羧酸、磺酸、—CH2OH、烷氧基、苯氧基、连接基和其取代形式的群。本发明还包括包含二苯基罗丹明化合物的能量转移染料，标记有二苯基罗丹明化合物的核苷酸，以及采用二苯基罗丹明化合物的核酸分析方法。