3-[(3-cyclopentyloxy-4-methoxyphenyl)methyl]-N-ethylpurin-6-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 3-[(3-cyclopentyloxy-4-methoxyphenyl)methyl]-N-ethylpurin-6-amine
• 化学式: C₂₀H₂₅N₅O₂
• 分子量: 367.4
• InChiKey: MRSICBMGHZMVGI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  74.1
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• [EN] NOVEL CHEMICAL COMPOUNDS HAVING PDE-IV INHIBITION ACTIVITY<br/>[FR] NOUVEAUX COMPOSES CHIMIQUES PRESENTANT UNE ACTIVITE D'INHIBITION DE LA PDE-IV (PHOSPHODIESTERASE IV)
  申请人：EURO-CELTIQUE S.A.

  公开号：WO1995000516A1

  公开（公告）日：1995-01-05

  (EN) Novel purine derivatives and their isoguanine and dithioxanthine precursor compounds are disclosed. These compounds have bronchial and tracheal relaxation and/or anti-inflammatory activity. The invention is also related to processes for their preparation, to pharmaceutical compositions containing them and to their medical use. In certain preferred embodiments, the invention relates to 3-substituted and 3,8-disubstituted 6-amino purine derivatives.(FR) On décrit de nouveaux dérivés de purine et leurs composés précurseurs à base d'isoguanine et de dithioxanthine. Ces composés présentent une activité de relaxation bronchique et trachéale et/ou anti-inflammatoire. L'invention concerne aussi leurs procédés de préparation, des compositions pharmaceutiques les contenant et leur utilisation médicale. Dans certaines variantes préférées, l'invention concerne des dérivés de 6-amino purine 3-substitués et 3,8 disubstitués.

  （中文）本发明揭示了新的嘌呤衍生物及其异鸟嘌呤和二硫黄黄质前体化合物。这些化合物具有支气管和气管松弛和/或抗炎活性。本发明还涉及它们的制备过程，含有它们的制药组合物以及它们的医疗用途。在某些优选实施例中，本发明涉及3-取代和3,8-二取代的6-氨基嘌呤衍生物。
• 6-Amino purine derivatives having PDE-IV inhibition activity and intermediates
  申请人：Euroceltique S.A.

  公开号：EP0916672A1

  公开（公告）日：1999-05-19

  Novel purine derivatives and their isoguanine and dithioxanthine precursor compounds are disclosed. These compounds have bronchial and tracheal relaxation and/or anti-inflammatory activity. The invention is also related to processes for their preparation, to pharmaceutical compositions containing them and to their medical use. In certain preferred embodiments, the invention relates to 3-substituted and 3,8-disubstituted 6-amino purine derivatives.

  本研究公开了新型嘌呤衍生物及其异鸟嘌呤和二硫黄嘌呤前体化合物。这些化合物具有舒张支气管和气管和/或抗炎活性。本发明还涉及它们的制备工艺、含有它们的药物组合物及其医疗用途。在某些优选的实施方案中，本发明涉及 3-取代和 3,8-二取代的 6-氨基嘌呤衍生物。
• 6-Amino purine derivatives having PDE-IV inhibition activity
  申请人：Euroceltique S.A.

  公开号：EP0916673A1

  公开（公告）日：1999-05-19

  Novel purine derivatives and their isoguanine and dithioxanthine precursor compounds are disclosed. These compounds have bronchial and tracheal relaxation and/or anti-inflammatory activity. The invention is also related to processes for their preparation, to pharmaceutical compositions containing them and to their medical use. In certain preferred embodiments, the invention relates to 3-substituted and 3,8-disubstituted 6-amino purine derivatives.

  本研究公开了新型嘌呤衍生物及其异鸟嘌呤和二硫黄嘌呤前体化合物。这些化合物具有舒张支气管和气管和/或抗炎活性。本发明还涉及它们的制备工艺、含有它们的药物组合物及其医疗用途。在某些优选的实施方案中，本发明涉及 3-取代和 3,8-二取代的 6-氨基嘌呤衍生物。
• NOVEL CHEMICAL COMPOUNDS HAVING PDE-IV INHIBITION ACTIVITY
  申请人：Euroceltique S.A.

  公开号：EP0705265A1

  公开（公告）日：1996-04-10
• IMPROVED METHODS FOR THE SYNTHESIS OF CHEMICAL COMPOUNDS HAVING PDE-IV INHIBITORY ACTIVITY
  申请人：Euro-Celtique S.A.

  公开号：EP0912575A1

  公开（公告）日：1999-05-06