7-[(3-Chloro-4-hydroxyphenyl)methyl]-8-(cyclohexylamino)-1-ethyl-3-(2-hydroxyethyl)purine-2,6-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 7-[(3-Chloro-4-hydroxyphenyl)methyl]-8-(cyclohexylamino)-1-ethyl-3-(2-hydroxyethyl)purine-2,6-dione
• 化学式: C₂₂H₂₈ClN₅O₄
• 分子量: 461.9
• InChiKey: BYVNFWVKLUDQAV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  32
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  111
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• XANTHINE PHOSPHODIESTERASE V INHIBITORS
  申请人：Schering Corporation

  公开号：EP1319003B1

  公开（公告）日：2009-06-10
• Methods of treating benign prostatic hyperplasia or lower urinary tract symptoms by using PDE 5 inhibitors
  申请人：Pickett Cecil

  公开号：US20070004745A1

  公开（公告）日：2007-01-04

  The use of PDE 5 inhibitors in methods for the treatment of benign prostatic hyperplasia or lower urinary tract symptoms and other physiological disorders, as a monotherapy and in combination with other active agents is disclosed. For example, a representative compound useful in the methods of the invention is:
• Methods of using PDE 5 inhibitors for the treatment of congestive heart failure
  申请人：Cuffie-Jackson Cynthia

  公开号：US20070037831A1

  公开（公告）日：2007-02-15

  The uses of PDE V inhibitors in methods for the treatment of congestive heart failure and other physiological disorders, as a monotherapy and in combination with other active agents are disclosed. Such PDE V inhibitors include those having the formula (I), with the variables defined herein: For example, a representative compound useful in the methods of the invention is:
• METHODS OF TREATING BENIGN PROSTATIC HYPERPLASIA OR LOWER URINARY TRACT SYMPTOMS BY USING PDE 5 INHIBITORS
  申请人：Pickett Cecil

  公开号：US20090105282A1

  公开（公告）日：2009-04-23

  The use of PDE 5 inhibitors in methods for the treatment of benign prostatic hyperplasia or lower urinary tract symptoms and other physiological disorders, as a monotherapy and in combination with other active agents is disclosed. For example, a representative compound useful in the methods of the invention is:
• METHODS OF USING PDE V INHIBITORS FOR THE TREATMENT OF CONGESTIVE HEART FAILURE
  申请人：Cuffie-Jackson Cynthia

  公开号：US20090149480A1

  公开（公告）日：2009-06-11

  The uses of PDE V inhibitors in methods for the treatment of congestive heart failure and other physiological disorders, as a monotherapy and in combination with other active agents are disclosed. Such PDE V inhibitors include those having the formula (I), with the variables defined herein: For example, a representative compound useful in the methods of the invention is: