1,2-(3-Octadecyloxypropane)-bis(dihydrogen phosphate) | 79868-59-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 英文名称: 1,2-(3-Octadecyloxypropane)-bis(dihydrogen phosphate)
• 英文别名: (1-Octadecoxy-3-phosphonooxypropan-2-yl) dihydrogen phosphate
• CAS: 79868-59-0
• 化学式: C₂₁H₄₆O₉P₂
• 分子量: 504.538
• InChiKey: KTTFPTWSOFETQT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  32
• 可旋转键数：
  24
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  143
• 氢给体数：
  4
• 氢受体数：
  9

文献信息

• LPA receptor agonists and antagonists and methods of use
  申请人：——

  公开号：US20030130237A1

  公开（公告）日：2003-07-10

  The present invention relates to compounds according to formula (I) as disclosed herein as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors; such methods including inhibiting LPA activity on an LPA receptor, modulating LPA receptor activity, treating cancer, enhancing cell proliferation, treating a wound, treating apoptosis or preserving or restoring function in a cell, tissue, or organ, culturing cells, preserving organ or tissue function, and treating a dermatological condition.

  本发明涉及根据所述的化合物的化学式(I)，以及包括这些化合物的药物组合物。还公开了使用这些化合物的方法，这些方法具有作为LPA受体的激动剂或拮抗剂的活性；这些方法包括抑制LPA对LPA受体的活性，调节LPA受体的活性，治疗癌症，增强细胞增殖，治疗伤口，治疗凋亡或保护或恢复细胞、组织或器官的功能，培养细胞，保护器官或组织功能，以及治疗皮肤病症。
• LPA RECEPTOR AGONISTS AND ANTAGONISTS AND METHODS OF USE
  申请人：THE UNIVERSITY OF TENNESSEE RESEARCH CORPORATION

  公开号：EP1263752A2

  公开（公告）日：2002-12-11
• EP1263752A4
  申请人：——

  公开号：EP1263752A4

  公开（公告）日：2003-07-30
• EP1427424A4
  申请人：——

  公开号：EP1427424A4

  公开（公告）日：2006-12-13
• TREATMENT OF CYSTIC DISEASE WITH LYSOPHOSPHATIDIC ACID ANTAGONISTS
  申请人：Blazer-Yost Bonnie

  公开号：US20110044973A1

  公开（公告）日：2011-02-24

  A method for treating cystic diseases is disclosed herein. The method comprises administering lysophosphatidic acid receptor antagonists.