2-(6-Methylpyridin-2-yl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 2-(6-Methylpyridin-2-yl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyridine
• 化学式: C₁₈H₁₅N₅S
• 分子量: 333.4
• InChiKey: FLMHPOCIZIPARJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  81.3
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Imidazolopyridines and methods of making and using the same
  申请人：Lee Wen-Cherng

  公开号：US20060135517A1

  公开（公告）日：2006-06-22

  Compounds of formula I possess unexpectedly high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders. In one embodiment, the invention features a compound of formula I:

  公式I的化合物具有意外的高亲和力，可用作Alk 5和/或Alk 4的拮抗剂，以预防和/或治疗多种疾病，包括纤维化疾病。在一种实施例中，本发明涉及公式I的化合物：
• IMIDAZOLOPYRIDINES AND METHODS OF MAKING AND USING THE SAME
  申请人：Biogen Idec MA Inc.

  公开号：EP1546112A2

  公开（公告）日：2005-06-29
• EP1546112A4
  申请人：——

  公开号：EP1546112A4

  公开（公告）日：2006-06-07
• METHODS OF TREATING VASCULAR INJURIES
  申请人：Biogen Idec MA, Inc.

  公开号：EP1804801A2

  公开（公告）日：2007-07-11
• EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS
  申请人：Ichida Justin

  公开号：US20120021519A1

  公开（公告）日：2012-01-26

  The disclosure features a method of producing a reprogrammed cell (e.g. an induced pluripotent stem cell or an undifferentiated cell) from a differentiated (e.g. somatic) cell. In some embodiments, the methods includes contacting a differentiated (e.g. somatic cell) with a TGFBR1 inhibitor or anti-TGF-β-antibody to produce a reprogrammed cell (e.g. pluripotent stem cell or undifferentiated cell). Embodiments of the present invention relate to a reprogrammed cell and methods and compositions for producing a chemically produced reprogrammed cell or populations thereof.