5-(1,3-Dioxoisoindol-2-yl)-2-(6,7,8,9-tetrahydrodibenzofuran-3-ylsulfonylamino)pentanoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 5-(1,3-Dioxoisoindol-2-yl)-2-(6,7,8,9-tetrahydrodibenzofuran-3-ylsulfonylamino)pentanoic acid
• 化学式: C₂₅H₂₄N₂O₇S
• 分子量: 496.5
• InChiKey: FUMCSHVGHRBUQI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  35
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  142
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Tricyclic sulfonamides and their derivatives as inhibitors of matrix metalloproteinases
  申请人：Warner-Lambert Company

  公开号：US20020169164A1

  公开（公告）日：2002-11-14

  Tricyclic sulfonamide compounds and derivatives are described as well as methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A, collagenase-3, and stromelysin-1 and for the treatment of multiple sclerosis, atherosclerotic plaque rupture, aortic aneurysm, heart failure, left ventricular dilation, restenosis, periodontal disease, or other autoimmune or inflammatory disorders dependent upon tissue invasion by leukocytes or other activated migrating cells, acute and chronic neurodegenerative disorders including stroke, head trauma, spinal cord injury, Alzheimer's disease, amyotrophic lateral sclerosis, cerebral amyloid angiopathy, AIDS, Parkinson's disease, Huntington's disease, prion diseases, myasthenia gravis, and Duchenne's muscular dystrophy.

  本文描述了三环磺酰胺化合物及其衍生物，以及其制备方法和药物组合物，其可作为基质金属蛋白酶（特别是明胶酶A，胶原酶-3和基质金属蛋白酶-1）的抑制剂，用于治疗多发性硬化症、动脉粥样硬化斑块破裂、主动脉瘤、心力衰竭、左心室扩张、再狭窄、牙周病或其他依赖于白细胞或其他活化迁移细胞的组织侵袭的自身免疫或炎症性疾病，急性和慢性神经退行性疾病，包括中风、头部创伤、脊髓损伤、阿尔茨海默病、肌萎缩侧索硬化、脑淀粉样血管病、艾滋病、帕金森病、亨廷顿病、朊病、重症肌无力和杜兴肌萎缩。
• TRICYCLIC SULFONAMIDES AND THEIR DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP1100792A1

  公开（公告）日：2001-05-23
• [EN] TRICYCLIC SULFONAMIDES AND THEIR DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES<br/>[FR] SULFONAMIDES TRICYCLIQUES ET LEURS DERIVES UTILISES COMME INHIBITEURS DES METALLOPROTEINASES MATRICIELLES
  申请人：WARNER LAMBERT CO

  公开号：WO2000006561A1

  公开（公告）日：2000-02-10

  Tricyclic sulfonamide compounds and derivatives are described as well as methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A, collagenase-3, and stromelysin-1 and for the treatment of multiple sclerosis, atherosclerotic plaque rupture, aortic aneurysm, heart failure, left ventricular dilation, restenosis, periodontal disease, corneal ulceration, treatment of burns, decubital ulcers, wound healing, cancer, inflammation, pain, arthritis, osteoporosis, renal disease, or other autoimmune or inflammatory disorders dependent upon tissue invasion by leukocytes or other activated migrating cells, acute and chronic neurodegenerative disorders including stroke, head trauma, spinal cord injury, Alzheimer's disease, amyotrophic lateral sclerosis, cerebral amyloid angiopathy, AIDS, Parkinson's disease, Huntington's disease, prion diseases, myasthenia gravis, and Duchenne's muscular dystrophy.