2-hydroxymethyl-butyronitrile

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-hydroxymethyl-butyronitrile
• 英文别名: 2-Hydroxymethyl-butyronitril；a-Hydroxymethyl-butyronitrile；2-(hydroxymethyl)butanenitrile
• 化学式: C₅H₉NO
• 分子量: 99.1326
• InChiKey: NBUCOPILRSUCHR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  44
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-hydroxymethyl-butyronitrile 在 sodium hydroxide 作用下， 生成 2-乙基丙烯酸 、 2-(羟基甲基)丁酸
  参考文献：
  名称：

  Detection of denervated but viable myocardium in cardiac sarcoidosis with I-123 MIBG and TI-201 SPECT imaging

  摘要：

  A 58-year-old man, who had biopsy-proven cardiac sarcoidosis, underwent Tl-201 and I-123 MIBG cardiac scintigraphy. Although no perfusion defect was identified by Tl-201, mild heterogeneity of I-123 MIBG uptake was present in the myocardium. The denervated but viable myocardium was demonstrated in the heart with sarcoidosis. Cardiac sympathetic nerve function was impaired in cardiac sarcoidosis, slightly improved with steroid therapy. I-123 MIBG scintigraphy may be useful to assess extent of myocardial involvement and response to therapy.

  DOI：

  10.1007/bf02988246
• 作为产物：
  描述：

  2-hydroxymethyl-but-3-enenitrile 在 palladium on activated charcoal 、 乙醇 作用下， 生成 2-hydroxymethyl-butyronitrile
  参考文献：
  名称：

  Detection of denervated but viable myocardium in cardiac sarcoidosis with I-123 MIBG and TI-201 SPECT imaging

  摘要：

  A 58-year-old man, who had biopsy-proven cardiac sarcoidosis, underwent Tl-201 and I-123 MIBG cardiac scintigraphy. Although no perfusion defect was identified by Tl-201, mild heterogeneity of I-123 MIBG uptake was present in the myocardium. The denervated but viable myocardium was demonstrated in the heart with sarcoidosis. Cardiac sympathetic nerve function was impaired in cardiac sarcoidosis, slightly improved with steroid therapy. I-123 MIBG scintigraphy may be useful to assess extent of myocardial involvement and response to therapy.

  DOI：

  10.1007/bf02988246

文献信息

• Detection of denervated but viable myocardium in cardiac sarcoidosis with I-123 MIBG and TI-201 SPECT imaging
  作者：Shinro Matsuo、Yasuyuki Nakamura、Toshiki Matsui、Tetsuya Matsumoto、Masahiko Kinoshita

  DOI：10.1007/bf02988246

  日期：2001.8

  A 58-year-old man, who had biopsy-proven cardiac sarcoidosis, underwent Tl-201 and I-123 MIBG cardiac scintigraphy. Although no perfusion defect was identified by Tl-201, mild heterogeneity of I-123 MIBG uptake was present in the myocardium. The denervated but viable myocardium was demonstrated in the heart with sarcoidosis. Cardiac sympathetic nerve function was impaired in cardiac sarcoidosis, slightly improved with steroid therapy. I-123 MIBG scintigraphy may be useful to assess extent of myocardial involvement and response to therapy.