RWJ 38293

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: RWJ 38293
• 英文别名: 3-oxo-N-pyridin-4-yl-2,5-dihydro-1H-pyrido[1,2-a]benzimidazole-4-carboxamide
• 化学式: C₁₇H₁₄N₄O₂
• 分子量: 306.324
• InChiKey: HCDWYCQAHCMGPQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  74.3
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  RWJ 38293 在 manganese(IV) oxide 作用下， 以 xylene 为溶剂， 以65%的产率得到3-Oxo-3,5-dihydro-benzo[4,5]imidazo[1,2-a]pyridine-4-carboxylic acid pyridin-4-ylamide
  参考文献：
  名称：

  Potential anxiolytic agents. 2. Improvement of oral efficacy for the pyrido[1,2-a]benzimidazole (PBI) class of GABA-A receptor modulators

  摘要：

  We have further explored the structure-activity relationships of pyrido[1,2-a]benzimidazole (PBI) derivatives (viz. prototype 1), a novel series of central GABA-A receptor modulators, with the intent of enhancing oral efficacy. A study involving the introduction of acidic or basic groups led to the identification of RWJ-38293 (3a) as a potential anxiolytic agent.

  DOI：

  10.1016/0960-894x(96)00025-x

文献信息

• Potential anxiolytic agents. 2. Improvement of oral efficacy for the pyrido[1,2-a]benzimidazole (PBI) class of GABA-A receptor modulators
  作者：Bruce E Maryanoff、David F McComsey、Winston Ho、Richard P Shank、Barry Dubinsky

  DOI：10.1016/0960-894x(96)00025-x

  日期：1996.2

  We have further explored the structure-activity relationships of pyrido[1,2-a]benzimidazole (PBI) derivatives (viz. prototype 1), a novel series of central GABA-A receptor modulators, with the intent of enhancing oral efficacy. A study involving the introduction of acidic or basic groups led to the identification of RWJ-38293 (3a) as a potential anxiolytic agent.