2-N-(2-aminoethyl)-6-N-[(4-chlorophenyl)methyl]-9-propan-2-ylpurine-2,6-diamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 2-N-(2-aminoethyl)-6-N-[(4-chlorophenyl)methyl]-9-propan-2-ylpurine-2,6-diamine
• 化学式: C₁₇H₂₂ClN₇
• 分子量: 359.9
• InChiKey: GAHPGKPVCMMRHX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  93.7
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Purine inhibitors of cyclin dependent kinase 2 and IkappaB-alpha
  申请人：Lum T. Robert

  公开号：US20050080261A1

  公开（公告）日：2005-04-14

  Compounds of the following formula are provided: In the Formula (I), R 1 is —X—R 1 ′; in which R 1 ′ is optionally substituted lower alkyl, optionally substituted aryl, optionally substituted heteroaryl, or optionally substituted heterocyclyl, and X is —NH—. R 2 is lower alkyl optionally substituted with one, two or three groups chosen from hydroxy, lower alkoxy, and halogen. And R 3 is —NR 4 R 5 ; in which R 4 is hydrogen and R 5 is lower alkyl substituted with amino; or (ii) R 4 and R 5 are both lower alkyl optionally substituted with one, two or three groups chosen from hydroxy and amino. It is to be understood that R 1 ′ is not cyclohexylmethyl, phenyl, substituted phenyl, benzyl, phenylethyl, or m-hydroxybenzyl. The compounds inhibit CDK-2 activity and are useful for treating disorders characterized by undesirable cell proliferation.

  提供以下公式的化合物：在公式（I）中，R1为—X—R1′；其中R1′为可选择取代的低烷基、可选择取代的芳基、可选择取代的杂芳基或可选择取代的杂环烷基，X为—NH—。R2为低烷基，可选择取代一个、两个或三个羟基、低烷氧基或卤素基。R3为—NR4R5；其中R4为氢，R5为取代氨基的低烷基；或（ii）R4和R5均为低烷基，可选择取代一个、两个或三个羟基和氨基。应理解R1′不是环己基甲基、苯基、取代苯基、苄基、苯乙基或间羟基苄基。这些化合物能够抑制CDK-2活性，并用于治疗具有不良细胞增殖特征的疾病。
• Purine inhibitors of cyclin dependent kinase 2 & IkBa
  申请人：——

  公开号：US20020035252A1

  公开（公告）日：2002-03-21

  A 2,6,9-trisubstituted purine composition that is useful for inhibiting cell proliferative disorders and as an antifungal agent.

  一种2,6,9-三取代嘌呤组合物，可用于抑制细胞增殖性疾病和作为抗真菌剂。
• Polymer coating for medical devices
  申请人：CV THERAPEUTICS, INC.

  公开号：EP1764118A2

  公开（公告）日：2007-03-21

  The present invention relates to a coating for a medical device having a body fluid-contacting surface for contacting blood or other body fluids, the coating comprising: a silane derivative layer covalently bonded to the body fluid-contacting surface of the medical device, said silane derivative layer containing hydroxyl or amino functional groups; a lactone polymer layer polymerized on the hydroxyl or amino functional groups of the silane derivative layer through in-situ ring opening graft polymerization of lactone monomers, said polymerization initiated by said hydroxyl or amino functional groups of the silane derivative layer; at least one polyester polymer layer comprising one or more biologically active agents deposited on the lactone polymer layer, wherein at least the first layer of the at least one polyester polymer layer is chemically compatible with the lactone polymer layer to allow for entanglement of the polyester polymer chains with the lactone polymer chains; and optionally at least one polymer layer deposited on said at least one polyester polymer layer forming a skin or barrier layer.

  本发明涉及一种用于医疗设备的涂层，该医疗设备具有用于接触血液或其他体液的体液接触表面，该涂层包括 共价键合到医疗设备体液接触表面的硅烷衍生物层，所述硅烷衍生物层含有羟基或氨基官能团； 通过内酯单体原位开环接枝聚合在硅烷衍生物层的羟基或氨基官能团上聚合的内酯聚合物层，所述聚合由硅烷衍生物层的所述羟基或氨基官能团引发； 至少一个聚酯聚合物层，包含沉积在内酯聚合物层上的一种或多种生物活性剂，其中至少一个聚酯聚合物层的至少第一层与内酯聚合物层化学相容，以允许聚酯聚合物链与内酯聚合物链缠结；以及 可选择在所述至少一层聚酯聚合物层上沉积至少一层聚合物层，形成表皮层或阻隔层。
• PURINE INHIBITORS OF CYCLIN DEPENDENT KINASE 2 AND I$g(k)-A$g(a)
  申请人：CV THERAPEUTICS, INC.

  公开号：EP1150982A1

  公开（公告）日：2001-11-07
• PURINE INHIBITORS OF CYCLIN DEPENDENT KINASE 2 AND IkB-alpha
  申请人：CV THERAPEUTICS, INC.

  公开号：EP1150982B1

  公开（公告）日：2005-10-12