LysBH(2,2)IAM

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: LysBH(2,2)IAM
• 英文别名: 6-(4-Aminobutyl)-48,49,63,64-tetrahydroxy-1,4,7,15,18,21,24,32,37,45,52,60-dodecazaheptacyclo[19.13.13.134,18.19,13.126,30.139,43.154,58]tetrahexaconta-9,11,13(63),26(49),27,29,39,41,43(48),54(64),55,57-dodecaene-8,14,25,31,38,44,53,59-octone
• 化学式: C₅₆H₇₃N₁₃O₁₂
• 分子量: 1120.28
• InChiKey: OFNWADQPQAAWAR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  81
• 可旋转键数：
  4
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  353
• 氢给体数：
  13
• 氢受体数：
  17

反应信息

• 作为反应物：
  描述：

  二甘醇酸 、 LysBH(2,2)IAM 生成 2-[2-Oxo-2-[4-(48,49,63,64-tetrahydroxy-8,14,25,31,38,44,53,59-octaoxo-1,4,7,15,18,21,24,32,37,45,52,60-dodecazaheptacyclo[19.13.13.134,18.19,13.126,30.139,43.154,58]tetrahexaconta-9,11,13(63),26(49),27,29,39,41,43(48),54(64),55,57-dodecaen-6-yl)butylamino]ethoxy]acetic acid
  参考文献：
  名称：

  WO2008/92120

  摘要：

  公开号：
• 作为产物：
  描述：

  Me4BocLysBH(2,2)IAM 在 三溴化硼 、 水 作用下， 以 二氯甲烷 、 甲醇 为溶剂， 反应 120.0h， 以53%的产率得到LysBH(2,2)IAM
  参考文献：
  名称：

  WO2008/63721

  摘要：

  公开号：

文献信息

• [EN] RADIOPHARMACEUTICAL COMPLEXES<br/>[FR] COMPLEXES RADIOPHARMACEUTIQUES
  申请人：LUMIPHORE INC

  公开号：WO2011079291A1

  公开（公告）日：2011-06-30

  The invention provides compounds such as chelating agents useful in chelating metal ions, particularly radionuclides, to provide metal ion complexes. The invention also provides methods of using the compounds and complexes of the invention, such as in therapeutic and diagnostic applications.

  该发明提供了化合物，如螯合剂，可用于螯合金属离子，特别是放射性核素，以提供金属离子络合物。该发明还提供了使用该化合物和该发明的络合物的方法，例如在治疗和诊断应用中。
• LUMINESCENT MACROCYCLIC LANTHANIDE COMPLEXES
  申请人：Raymond Kenneth N.

  公开号：US20080213917A1

  公开（公告）日：2008-09-04

  The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds incorporate hydroxy-isophthalamide moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability. These characteristics distinguish them from known, open-structured ligands.

  本发明提供了一种新的大环化合物类别，以及由金属（例如镧系金属）离子和本发明中化合物形成的配合物。首选的配合物在水介质中表现出高稳定性以及高量子产率的镧系离子发光特性，无需使用次级活化剂。首选化合物在其大环结构中包含羟基异苯酰胺基团，并以惊人的低非特异性结合多种多肽（如抗体和蛋白质）以及高动力学稳定性为特征。这些特征使它们与已知的开放结构配体有所区别。
• [EN] EUROPIUM(III) COMPLEXES AS PH SENSORS<br/>[FR] COMPLEXES D'EUROPIUM (III) UTILISÉS COMME CAPTEURS DE PH
  申请人：CISBIO BIOASSAYS

  公开号：WO2022090284A1

  公开（公告）日：2022-05-05

  The invention relates to a compound of formula (I) wherein R1; R2, R3and R4are as defined in the description. The invention also relates to europium (III) complexes obtained from a compound of formula (I), or from a complexing agent including said compound, and to the use of such complexes to label organic or biological molecules.

  本发明涉及一种式为（I）的化合物，其中R1，R2，R3和R4如描述中所定义。本发明还涉及从式为（I）的化合物或包括该化合物的络合剂获得的铕（III）配合物，以及使用这种配合物标记有机或生物分子的方法。
• MULTI-COLOR TIME RESOLVED FLUOROPHORES BASED ON MACROCYCLIC LANTHANIDE COMPLEXES
  申请人：Butlin Nathaniel G.

  公开号：US20080213780A1

  公开（公告）日：2008-09-04

  The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds incorporate hydroxy-isophthalamide moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability. These characteristics distinguish them from known, open-structured ligands.
• US8173800B2
  申请人：——

  公开号：US8173800B2

  公开（公告）日：2012-05-08