2-amino-3-[hydroxy-[3-octadecanoyloxy-2-[(Z)-octadec-9-enoyl]oxypropoxy]phosphoryl]oxypropanoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 英文名称: 2-amino-3-[hydroxy-[3-octadecanoyloxy-2-[(Z)-octadec-9-enoyl]oxypropoxy]phosphoryl]oxypropanoic acid
• 化学式: C₄₂H₈₀NO₁₀P
• 分子量: 790.1
• InChiKey: AJFWREUFUPEYII-ZZEZOPTASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.1
• 重原子数：
  54
• 可旋转键数：
  43
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  172
• 氢给体数：
  3
• 氢受体数：
  11

文献信息

• LIPOSOMAL COMPOSITIONS WITH LIGHT ILLUMINATION-INDUCED DRUG RELEASE
  申请人：Creighton University

  公开号：US20180243419A1

  公开（公告）日：2018-08-30

  Provided herein is a small molecule delivery system with illumination-induced small molecule release based on the binary combination of charged liposomes containing small molecules and oppositely charged conjugates of a peptide with a photosensitizer attached to one end of peptide chain, providing binding to liposomes and their permeabilization upon light illumination.

  这里提供了一种小分子递送系统，其基于带电脂质体和带有光敏剂的肽共轭物的二元组合，通过光照诱导小分子释放，提供与脂质体的结合和光照下的渗透性，从而实现小分子的释放。
• GRAPHENE-INDUCED ENERGY TRANSFER FOR THE QUANTIFICATION OF THE STRUCTURE AND DYNAMICS OF BIOMOLECULES
  申请人：Universität Osnabrück

  公开号：EP3912955A1

  公开（公告）日：2021-11-24

  The present invention relates in general to structure and activity determination of biomolecules. More specifically, the present invention relates to methods of manufacturing devices having a support layer and a biofunctionalized graphene layer on top of the support layer, and the use of such devices for hybridization, determining the structure and structural dynamics of biomolecules, in particular nucleotides, proteins and protein complexes. The present invention also relates to novel compounds for biofunctionalization of graphene, in particular novel amphiphilic molecules for noncovalent surface coating of a graphene layer, and their use in the manufacturing methods and devices of the present invention.

  本发明总体上涉及生物分子的结构和活性测定。更具体地说，本发明涉及制造具有支撑层和位于支撑层之上的生物功能化石墨烯层的装置的方法，以及使用这种装置进行杂交、确定生物大分子（特别是核苷酸、蛋白质和蛋白质复合物）的结构和结构动态的方法。本发明还涉及用于石墨烯生物功能化的新型化合物，特别是用于石墨烯层非共价表面涂层的新型两亲分子，以及它们在本发明制造方法和装置中的用途。
• Liposomal compositions with light illumination-induced drug release
  申请人：Creighton University

  公开号：US11154619B2

  公开（公告）日：2021-10-26

  Provided herein is a small molecule delivery system with illumination-induced small molecule release based on the binary combination of charged liposomes containing small molecules and oppositely charged conjugates of a peptide with a photosensitizer attached to one end of peptide chain, providing binding to liposomes and their permeabilization upon light illumination.

  本文提供了一种具有光照诱导小分子释放功能的小分子给药系统，该系统基于含有小分子的带电脂质体和肽的带相反电荷的共轭物的二元组合，肽链的一端附有光敏剂，在光照下可与脂质体结合并使其通透。
• Immunotherapeutic Nanoparticles And Methods Relating Thereto
  申请人：Wake Forest University Health Sciences

  公开号：US20220193108A1

  公开（公告）日：2022-06-23

  Compositions containing lipid nanoparticles and nucleic acid therapeutic agents are disclosed. For example, calcium phosphate nanoparticles having a lipid coating are provided, wherein the calcium phosphate nanoparticles include a cyclic dinucleotide and the lipid coating includes phosphatidylserine. The compositions can be formulated for administration to the lungs of a subject via inhalation, or for administration via injection. Methods for the treatment of lung cancer and other cancers are also described. Targeted delivery of therapeutic agents such as cyclic dinucleotides to antigen presenting immune cells via the disclosed methods can elicit beneficial antitumor immunity.
• [EN] IMMUNOTHERAPEUTIC NANOPARTICLES AND METHODS RELATING THERETO<br/>[FR] NANOPARTICULES IMMUNOTHÉRAPEUTIQUES ET PROCÉDÉS ASSOCIÉS
  申请人：UNIV WAKE FOREST HEALTH SCIENCES

  公开号：WO2020210317A1

  公开（公告）日：2020-10-15

  Compositions containing lipid nanoparticles and nucleic acid therapeutic agents are disclosed. For example, calcium phosphate nanoparticles having a lipid coating are provided, wherein the calcium phosphate nanoparticles include a cyclic dinucleotide and the lipid coating includes phosphatidylserine. The compositions can be formulated for administration to the lungs of a subject via inhalation, or for administration via injection. Methods for the treatment of lung cancer and other cancers are also described. Targeted delivery of therapeutic agents such as cyclic dinucleotides to antigen presenting immune cells via the disclosed methods can elicit beneficial antitumor immunity.