(9H-fluoren-2-yl)-isopropyl-amine | 350016-48-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: (9H-fluoren-2-yl)-isopropyl-amine
• 英文别名: N-propan-2-yl-9H-fluoren-2-amine
• CAS: 350016-48-7
• 化学式: C₁₆H₁₇N
• mdl: MFCD11142621
• 分子量: 223.318
• InChiKey: CXUBPVWDZNMOMN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Tricyclic compounds and method of treating herpes virus
  申请人：——

  公开号：US20030229073A1

  公开（公告）日：2003-12-11

  The present invention provides a compound of the formula (I) and pharmaceutically acceptable salts having useful antiviral activity against viruses of the herpes family. In said formula, X=O, (CH 2 ) m , S, SO, SO 2 , NH, NR 8 or a chemical bond; Y=O, (CH 2 ) m , S, SO, SO 2 , NH, NR 8 ; Z=NH, O, NR 8 , S, SO, SO 2 . The remaining substituents are described in the specification.

  本发明提供了一种公式(I)的化合物及其药学上可接受的盐，对于单纯疱疹病毒家族的病毒具有有用的抗病毒活性。在该式中，X=O、(CH2)m、S、SO、SO2、NH、NR8或化学键；Y=O、( )m、S、SO、SO2、NH、NR8；Z=NH、O、NR8、S、SO、SO2。其余的取代基在说明书中描述。
• Compounds for inhibiting drug-resistant strains of HIV-1 integrase
  申请人：The United States of America, as represented by the Secretary, Department of Health and Human Services

  公开号：US10208035B2

  公开（公告）日：2019-02-19

  A method of inhibiting drug-resistant HIV-1 integrase in a subject comprising administering to a subject in need thereof a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt or ester thereof, having a structure of: wherein X is N, C(OH), or CH; Y is H or OH; each of Z1-Z5 is independently H or halogen; R4 is H, OH, NH2, NHR8, NR8R9 or R8; R5, R6, and R7 is each independently H, halogen, OR8, R8, NHR8, NR8R9, CO2R8, CONR8R9, SO2NR8R9, or R5 and R6 together with the carbon atoms to which R5 and R6 are attached form an optionally-substituted carbocycle or optionally-substituted heterocycle; and R8 and R9 is each independently H, optionally-substituted alkyl, optionally-substituted alkenyl, optionally-substituted alkynyl, optionally-substituted aryl, optionally-substituted cycloalkyl, optionally-substituted cycloalkylene, optionally-substituted heterocycle, optionally-substituted amide, optionally-substituted ester, or R8 and R9 together with the nitrogen to which R8 and R9 are attached form an optionally-substituted heterocycle.

  一种抑制受试者体内耐药 HIV-1 整合酶的方法，包括向有需要的受试者施用治疗有效量的式 I 化合物或其药学上可接受的盐或酯，其结构为： 其中 X 是 N、C(OH)或 CH； Y 是 H 或 OH； Z1-Z5 各自独立地为 H 或卤素； R4 是 H、OH、NH2、NHR8、NR8R9 或 R8； R5、R6 和 R7 各自独立地为 H、卤素、OR8、R8、NHR8、NR8R9、CO2R8、CONR8R9、SO2NR8R9，或 R5 和 R6 与 R5 和 R6 所连接的碳原子一起形成任选取代的碳环或任选取代的杂环；以及 R8 和 R9 各自独立地为 H、任选取代的烷基、任选取代的烯基、任选取代的炔基、任选取代的芳基、任选取代的环烷基、任选取代的环亚烷基、任选取代的杂环、任选取代的酰胺、任选取代的酯，或 R8 和 R9 与 R8 和 R9 所连接的氮一起形成任选取代的杂环。
• Tricyclic compounds with antiviral activity
  申请人：Booth John Richard

  公开号：US20050075332A1

  公开（公告）日：2005-04-07

  The present invention provides a compound of the formula (I) and pharmaceutically acceptable salts having useful antiviral activity against viruses of the herpes family. In said formula, X═O, (CH 2 ) m , S, SO, SO 2 , NH, NR 8 , or a chemical bond; Y═O, (CH 2 ) m , S, SO, SO 2 , NH, NR 8 ; Z=NH, O, NR 8 , S, SO, SO 2 . The remaining substituents are described in the specification.
• COMPOUNDS FOR INHIBITING DRUG-RESISTANT STRAINS OF HIV-1 INTEGRASE
  申请人：The United States of America, as represented by the Secretary, Department of Health and Human Serv

  公开号：US20170305904A1

  公开（公告）日：2017-10-26

  A method of inhibiting drug-resistant HIV-1 integrase in a subject comprising administering to a subject in need thereof a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt or ester thereof, having a structure of: wherein X is N, C(OH), or CH; Y is H or OH; each of Z 1 -Z 5 is independently H or halogen; R 4 is H, OH, NH 2 , NHR 8 , NR 8 R 9 or R 8 ; R 5 , R 6 , and R 7 is each independently H, halogen, OR 8 , R 8 , NHR 8 , NR 8 R 9 , CO 2 R 8 , CONR 8 R 9 , SO 2 NR 8 R 9 , or R 5 and R 6 together with the carbon atoms to which R 5 and R 6 are attached form an optionally-substituted carbocycle or optionally-substituted heterocycle; and R 8 and R 9 is each independently H, optionally-substituted alkyl, optionally-substituted alkenyl, optionally-substituted alkynyl, optionally-substituted aryl, optionally-substituted cycloalkyl, optionally-substituted cycloalkylene, optionally-substituted heterocycle, optionally-substituted amide, optionally-substituted ester, or R 8 and R 9 together with the nitrogen to which R 8 and R 9 are attached form an optionally-substituted heterocycle.
• US6800656B2
  申请人：——

  公开号：US6800656B2

  公开（公告）日：2004-10-05