(2R,3S,4S)-2-(hydroxymethyl)-1-methylthiolan-1-ium-3,4-diol;iodide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 硫杂环戊烷
• 英文名称: (2R,3S,4S)-2-(hydroxymethyl)-1-methylthiolan-1-ium-3,4-diol;iodide
• 化学式: C₆H₁₃O₃S*I
• 分子量: 292.138
• InChiKey: JROVVTMLFYHVFM-CXYWKTTNSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -4.67
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  61.7
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (2R,3S,4S)-2-(hydroxymethyl)tetrahydrothiophene-3,4-diol 、 碘甲烷 在 碳酸氢钠 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 12.0h， 以69%的产率得到(2R,3S,4S)-2-(hydroxymethyl)-1-methylthiolan-1-ium-3,4-diol;iodide
  参考文献：
  名称：

  Glycosidase Inhibition by cyclic sulfonium compounds

  摘要：

  Inhibitory activities of various cyclic sulfonium compounds including salacinol against several glycosidases were studied and some compounds showed significant inhibition. The sulfonium ion structure was found to be essential for the inhibitory activity. Specific inhibition of salacinol toward rice alpha -glucosidase was ascribed to the tether arm. (C) 2001 Elsevier Science Ltd. Ail rights reserved.

  DOI：

  10.1016/s0960-894x(01)00155-x

文献信息

• Glycosidase Inhibition by cyclic sulfonium compounds
  作者：Hideya Yuasa、Jun Takada、Hironobu Hashimoto

  DOI：10.1016/s0960-894x(01)00155-x

  日期：2001.5

  Inhibitory activities of various cyclic sulfonium compounds including salacinol against several glycosidases were studied and some compounds showed significant inhibition. The sulfonium ion structure was found to be essential for the inhibitory activity. Specific inhibition of salacinol toward rice alpha -glucosidase was ascribed to the tether arm. (C) 2001 Elsevier Science Ltd. Ail rights reserved.