(E)-3-diethoxyphosphoryl-N-methyl-1-(4-methylphenyl)-2-phenylprop-2-en-1-amine

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (E)-3-diethoxyphosphoryl-N-methyl-1-(4-methylphenyl)-2-phenylprop-2-en-1-amine
• 化学式: C₂₁H₂₈NO₃P
• 分子量: 373.432
• InChiKey: MVCSVPCLJXEBTH-CAPFRKAQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  26
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  p-methylbenzylidene-methylamine 、 diethyl phenylethynylphosphonate 在 titanium(IV) isopropylate 、 异丙基氯化镁 作用下， 以 乙醚 为溶剂， 反应 3.0h， 以79%的产率得到(E)-3-diethoxyphosphoryl-N-methyl-1-(4-methylphenyl)-2-phenylprop-2-en-1-amine
  参考文献：
  名称：

  Novel One-Pot Synthesis of 3-Amino-1-alkenylphophonates by Addition of Imines to Alkynylphosphonate Titanium(II) Complexes

  摘要：

  A new method of synthesis of 3-amino-1-alkenylphosphonates is described. It involves the addition of imines to the alkynylphosphonate titanium(II) complexes 2, which are prepared in situ from 1-alkynylphosphonates and Ti(O-i-Pr)(4)/2 equiv of i-PrMgCl. Compounds 4a-i were obtained regio- and stereoselectivily in high yields.

  DOI：

  10.1021/ol027429a

文献信息

• Novel One-Pot Synthesis of 3-Amino-1-alkenylphophonates by Addition of Imines to Alkynylphosphonate Titanium(II) Complexes
  作者：Abed Al Aziz Al Quntar、Valery M. Dembitsky、Morris Srebnik

  DOI：10.1021/ol027429a

  日期：2003.2.1

  A new method of synthesis of 3-amino-1-alkenylphosphonates is described. It involves the addition of imines to the alkynylphosphonate titanium(II) complexes 2, which are prepared in situ from 1-alkynylphosphonates and Ti(O-i-Pr)(4)/2 equiv of i-PrMgCl. Compounds 4a-i were obtained regio- and stereoselectivily in high yields.