N-(2-methylphenyl)-1-(5-nitroisoquinolin-1-yl)methanimine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: N-(2-methylphenyl)-1-(5-nitroisoquinolin-1-yl)methanimine
• 化学式: C₁₇H₁₃N₃O₂
• 分子量: 291.309
• InChiKey: HKVRERJKRPJGLC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  71.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-甲基异喹啉 在 selenium(IV) oxide 、 硫酸 、 硝酸 作用下， 以 1,4-二氧六环 、 乙醇 为溶剂， 反应 6.0h， 生成 N-(2-methylphenyl)-1-(5-nitroisoquinolin-1-yl)methanimine
  参考文献：
  名称：

  Synthesis of novel functionalized 5-nitroisoquinolines and evaluation of in vitro antimalarial activity

  摘要：

  Novel aldimine and hydrazone isoquinoline derivatives were obtained after subjecting 1-formyl-5-nitroisoquinoline to classical reactions. Some of these compounds were found to have activity against a chloroquine-resistant Plasmodium falciparum strain (ACC Niger).

  DOI：

  10.1016/0223-5234(96)88261-4

文献信息

• Synthesis of novel functionalized 5-nitroisoquinolines and evaluation of in vitro antimalarial activity
  作者：P Rathelot、P Vanelle、M Gasquet、F Delmas、MP Crozet、P Timon-David、J Maldonado

  DOI：10.1016/0223-5234(96)88261-4

  日期：1995.1

  Novel aldimine and hydrazone isoquinoline derivatives were obtained after subjecting 1-formyl-5-nitroisoquinoline to classical reactions. Some of these compounds were found to have activity against a chloroquine-resistant Plasmodium falciparum strain (ACC Niger).