3-[(4-oxo-3,4-dihydroquinazolin-2-yl)amino]benzoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 3-[(4-oxo-3,4-dihydroquinazolin-2-yl)amino]benzoic acid
• 英文别名: 3-(4-oxo-3,4-dihydro-quinazolin-2-ylamino)-benzoic acid；3-(4-Oxo-3,4-dihydro-chinazolin-2-ylamino)-benzoesaeure；3-[(4-Oxo-3,4-dihydroquinazolin-2-yl)amino]benzoic acid；3-[(4-oxo-3H-quinazolin-2-yl)amino]benzoic acid
• 化学式: C₁₅H₁₁N₃O₃
• mdl: MFCD09904870
• 分子量: 281.271
• InChiKey: FDHAKPFFMVWAJP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  90.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-甲基磺酰基-4(3H-)-喹唑啉酮 、 间氨基苯甲酸 在 吡啶 作用下， 反应 8.0h， 以64%的产率得到3-[(4-oxo-3,4-dihydroquinazolin-2-yl)amino]benzoic acid
  参考文献：
  名称：

  Design, synthesis and biological evaluation of 2-aminopyrimidinones and their 6-aza-analogs as a new class of CK2 inhibitors

  摘要：

  In order to find the new potent CK2 inhibitors the 60 derivatives of 2-aminopyrimidinone and their 6-aza-substituted analogs were synthesized and tested in vitro. Among them, the most efficient inhibitor 2-hydroxy-5-[4-(4-methoxyphehyl)-6-oxo-1,6-dihydropyrimidin-2-ylamino] benzoic acid was identified (IC50 = 1.1 mu M). The structure-activity relationship study of newly synthesized derivatives was carried out and their binding mode with adenosine triphosphate-acceptor site of CK2 was proposed.

  DOI：

  10.3109/14756366.2013.837898

文献信息

• Griess, Chemische Berichte, 1885, vol. 18, p. 2420
  作者：Griess

  DOI：——

  日期：——
• US6525061B1
  申请人：——

  公开号：US6525061B1

  公开（公告）日：2003-02-25
• Design, synthesis and biological evaluation of 2-aminopyrimidinones and their 6-aza-analogs as a new class of CK2 inhibitors
  作者：Maksym O. Chekanov、Olga V. Ostrynska、Sergii S. Tarnavskyi、Anatoliy R. Synyugin、Nadiia V. Briukhovetska、Volodymyr G. Bdzhola、Alexander E. Pashenko、Andrey A. Fokin、Sergiy M. Yarmoluk

  DOI：10.3109/14756366.2013.837898

  日期：2014.10.1

  In order to find the new potent CK2 inhibitors the 60 derivatives of 2-aminopyrimidinone and their 6-aza-substituted analogs were synthesized and tested in vitro. Among them, the most efficient inhibitor 2-hydroxy-5-[4-(4-methoxyphehyl)-6-oxo-1,6-dihydropyrimidin-2-ylamino] benzoic acid was identified (IC50 = 1.1 mu M). The structure-activity relationship study of newly synthesized derivatives was carried out and their binding mode with adenosine triphosphate-acceptor site of CK2 was proposed.