4-fluoro-N-methyl-N-pentylaniline

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-fluoro-N-methyl-N-pentylaniline
• 化学式: C₁₂H₁₈FN
• 分子量: 195.28
• InChiKey: WWUCZFVWWUZLKW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  四氢吡喃 、 4-fluoro-N-methyl-N-pentylaniline 在 叔丁基过氧化氢 、 水 、 copper(II) bis(trifluoromethanesulfonate) 作用下， 以 neat (no solvent) 为溶剂， 反应 30.0h， 以62%的产率得到9-fluoro-6-pentyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
  参考文献：
  名称：

  Cu-catalyzed oxidative Povarov reactions between N-alkyl N-methylanilines and saturated oxa- and thiacycles

  摘要：

  Cu催化的氧化Povarov反应介于N,N-二烷基苯胺和饱和的氧杂环或硫杂环之间，使用叔丁基过氧化氢(TBHP)。

  DOI：

  10.1039/c5cc01287b

文献信息

• [EN] CYCLOSPORIN ANALOGUES FOR PREVENTING OR TREATING HEPATITIS C INFECTION<br/>[FR] ANALOGUES DE LA CYCLOSPORINE POUR PRÉVENIR OU TRAITER UNE INFECTION PAR L'HÉPATITE C
  申请人：ENANTA PHARM INC

  公开号：WO2010088573A1

  公开（公告）日：2010-08-05

  The present invention relates to cyclosporin analogues having antiviral activity against HCV and useful in the treatment of HCV infections. More particularly, the invention relates to novel cyclosporin analogue compounds, compositions containing such compounds and methods for using the same, as well as processes for making such compounds.
• [EN] CYCLOSPORIN ANALOGUES FOR PREVENTING OR TREATING HEPATITIS C<br/>[FR] ANALOGUES DE CYCLOSPORINE POUR PRÉVENIR OU TRAITER UNE HÉPATITE C
  申请人：ENANTA PHARM INC

  公开号：WO2015031381A1

  公开（公告）日：2015-03-05

  The present invention relates to novel cyclosporine analogues having antiviral activity against HCV and useful in the treatment of HCV infections. More particularly, the invention relates to novel cyclosporine analogue compounds, compositions containing such compounds and methods for using the same, as well as processes for making such compounds.
• Cu-catalyzed oxidative Povarov reactions between N-alkyl N-methylanilines and saturated oxa- and thiacycles
  作者：Rahul Kisan Kawade、Deepak B. Huple、Rong-Jing Lin、Rai-Shung Liu

  DOI：10.1039/c5cc01287b

  日期：——

  Cu-catalyzed oxidative Povarov reactions between N,N-dialkylanilines and saturated oxa- or thiacycles with tert-butyl hydroperoxide (TBHP) are described.

  Cu催化的氧化Povarov反应介于N,N-二烷基苯胺和饱和的氧杂环或硫杂环之间，使用叔丁基过氧化氢(TBHP)。