2-[2,3-bis[[(Z)-docos-13-enoyl]oxy]propoxy-hydroxyphosphoryl]oxyethyl-trimethylazanium

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 英文名称: 2-[2,3-bis[[(Z)-docos-13-enoyl]oxy]propoxy-hydroxyphosphoryl]oxyethyl-trimethylazanium
• 化学式: C52H101NO8P+
• 分子量: 899.3
• InChiKey: SDEURMLKLAEUAY-YEUCEMRASA-O

计算性质

• 辛醇/水分配系数(LogP)：
  18.2
• 重原子数：
  62
• 可旋转键数：
  50
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  108
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• LIPOSOMAL FORMULATION OF NONGLYCOSIDIC CERAMIDES AND USES THEREOF
  申请人：Ludwig Institute for Cancer Research, Ltd.

  公开号：EP2654779B1

  公开（公告）日：2018-02-28
• METHODS FOR PROMOTING TRAINED IMMUNITY WITH NANOBIOLOGIC COMPOSITIONS
  申请人：ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

  公开号：US20200261591A1

  公开（公告）日：2020-08-20

  The invention relates to therapeutic nanobiologic compositions and methods of treating patients who have cancer, by promoting trained immunity, which is the long-term increased responsiveness, the result of metabolic and epigenetic re-wiring of myeloid cells and their stem cells and progenitors in the bone marrow and spleen and blood induced by a primary insult, and characterized by increased cytokine excretion after re-stimulation with one or multiple secondary stimuli.