ethyl 2-(5-fluoro-2-hydroxyphenyl)-2-hydroxyacetate

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: ethyl 2-(5-fluoro-2-hydroxyphenyl)-2-hydroxyacetate
• 化学式: C₁₀H₁₁FO₄
• 分子量: 214.193
• InChiKey: GORKUMOSAOSRHJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  乙醛酸乙酯 、 4-氟苯酚 在 ytterbium(III) triflate 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 6.0h， 以81%的产率得到ethyl 2-(5-fluoro-2-hydroxyphenyl)-2-hydroxyacetate
  参考文献：
  名称：

  Ytterbium(III) Trifluoromethanesulfonate Catalyzed Electrophilic Aromatic Substitution with Glyoxalate and Lipase-Mediated Product Resolution:  A Convenient Route to Optically Active Aromatic α-Hydroxy Esters

  摘要：

  DOI：

  10.1021/jo991916v

文献信息

• Sulfamate derivative compounds for use in treating or alleviating pain
  申请人：Bio-Pharm Solutions Co., Ltd.

  公开号：US10081615B2

  公开（公告）日：2018-09-25

  The present invention relates to sulfamate derivative compounds and a composition for treating and/or alleviating pain containing the sulfamate derivative compounds or a pharmaceutically acceptable salt thereof as an active ingredient. More specifically the present invention relates to a pharmaceutical composition for treating or alleviating pain containing a sulfamate derivative compound and/or a pharmaceutically acceptable salt thereof as an active ingredient. Furthermore, the present invention relates to a method for treatment or alleviation of pain comprising administering a sulfamate derivative compound in a pharmaceutically effective amount to a subject in need of treatment or alleviation of pain.

  本发明涉及氨基磺酸盐衍生物化合物和一种治疗和/或减轻疼痛的组合物，其中含有氨基磺酸盐衍生物化合物或其药学上可接受的盐作为活性成分。更具体地说，本发明涉及一种治疗或减轻疼痛的药物组合物，其中含有一种氨基磺酸盐衍生物化合物和/或其药学上可接受的盐作为活性成分。此外，本发明还涉及一种治疗或减轻疼痛的方法，该方法包括向需要治疗或减轻疼痛的受试者施用药学有效量的氨基磺酸盐衍生物化合物。
• [EN] SULFAMATE DERIVATIVE COMPOUNDS FOR USE IN TREATING OR ALLEVIATING PAIN<br/>[FR] COMPOSÉS DÉRIVÉS DE SULFAMATE DESTINÉS À ÊTRE UTILISÉS POUR LE TRAITEMENT OU LE SOULAGEMENT DE LA DOULEUR
  申请人：BIO PHARM SOLUTIONS CO LTD

  公开号：WO2015088272A9

  公开（公告）日：2015-10-01
• SULFAMATE DERIVATIVE COMPOUNDS FOR USE IN TREATING OR ALLEVIATING PAIN
  申请人：Bio-Pharm Solutions Co., Ltd.

  公开号：EP3079687B1

  公开（公告）日：2018-02-28
• Sulfamate Derivative Compounds for Use in Treating or Alleviating Pain
  申请人：BIO-PHARM SOLUTIONS CO., LTD.

  公开号：US20160311792A1

  公开（公告）日：2016-10-27

  The present invention relates to sulfamate derivative compounds and a composition for treating and/or alleviating pain containing the sulfamate derivative compounds or a pharmaceutically acceptable salt thereof as an active ingredient. More specifically the present invention relates to a pharmaceutical composition for treating or alleviating pain containing a sulfamate derivative compound and/or a pharmaceutically acceptable salt thereof as an active ingredient. Furthermore, the present invention relates to a method for treatment or alleviation of pain comprising administering a sulfamate derivative compound in a pharmaceutically effective amount to a subject in need of treatment or alleviation of pain.