2-hexyl-2,3-dihydro-1H-benzo[a][1,3]oxazino[6,5-c]phenazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-hexyl-2,3-dihydro-1H-benzo[a][1,3]oxazino[6,5-c]phenazine
• 英文别名: 4-Hexyl-6-oxa-4,15,22-triazapentacyclo[12.8.0.02,7.08,13.016,21]docosa-1(22),2(7),8,10,12,14,16,18,20-nonaene；4-hexyl-6-oxa-4,15,22-triazapentacyclo[12.8.0.02,7.08,13.016,21]docosa-1(22),2(7),8,10,12,14,16,18,20-nonaene
• 化学式: C₂₄H₂₅N₃O
• 分子量: 371.482
• InChiKey: UJLVYHKDLGZWAR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  38.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  聚合甲醛 、 正己胺 、 benzo[a]phenazin-5-ol 以 水 为溶剂， 反应 1.17h， 以86%的产率得到2-hexyl-2,3-dihydro-1H-benzo[a][1,3]oxazino[6,5-c]phenazine
  参考文献：
  名称：

  An efficient catalyst-free synthesis of novel benzo[a][1,3]oxazino[6,5-c]phenazine derivatives via one pot four-component domino protocol in water

  摘要：

  A catalyst-free multicomponent reaction (MCR) capable of affording a wide range of novel benzo[a][1,3]oxazino[6,5-c]phenazine derivatives via one pot two-step domino protocol, in water is reported. Catalyst-free conditions along with green solvent system make the process ecofriendly as well as economical. Simple reaction conditions, easy work-up isolation, and purification of products are the significant advantages of the present protocol. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.10.067

文献信息

• An efficient catalyst-free synthesis of novel benzo[a][1,3]oxazino[6,5-c]phenazine derivatives via one pot four-component domino protocol in water
  作者：Garima Khanna、Ankita Chaudhary、Jitender M. Khurana

  DOI：10.1016/j.tetlet.2014.10.067

  日期：2014.12

  A catalyst-free multicomponent reaction (MCR) capable of affording a wide range of novel benzo[a][1,3]oxazino[6,5-c]phenazine derivatives via one pot two-step domino protocol, in water is reported. Catalyst-free conditions along with green solvent system make the process ecofriendly as well as economical. Simple reaction conditions, easy work-up isolation, and purification of products are the significant advantages of the present protocol. (C) 2014 Elsevier Ltd. All rights reserved.