N,N'-bis(5-chlorosalicylidenato)-1,2-diaminopropane

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: N,N'-bis(5-chlorosalicylidenato)-1,2-diaminopropane
• 化学式: C₁₇H₁₆Cl₂N₂O₂
• 分子量: 351.232
• InChiKey: SABXNBVSLNUCNK-VDEHPEQNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.33
• 重原子数：
  23.0
• 可旋转键数：
  5.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  65.18
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  1,2-丙二胺 、 5-氯代水杨醛 以 甲醇 为溶剂， 反应 72.0h， 以86%的产率得到N,N'-bis(5-chlorosalicylidenato)-1,2-diaminopropane
  参考文献：
  名称：

  Synthesis and antimicrobial activities of Schiff bases derived from 5-chloro-salicylaldehyde

  摘要：

  A series of Schiff bases (compounds 1-26) were synthesized by reacting 5-chloro-salicylaldehyde and primary amines, 15 (compounds 2-4, 6, 7, 10, 12-17, 23, 25 and 26) of which were first reported. The chemical structures of these compounds were confirmed by means of H-1 NMR, C-13 NMR, ESI-MS and elemental analyses. The compounds were assayed for antibacterial (Bacillus subtilis, Escherichia coli, Pseudomonas fluorescence and Staphylococcus aureus) and antifungal (Aspergillus niger, Candida albicans and Trichophyton rubrum) activities by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl trtrazolium bromide) method. Among the compounds tested, (E)-4-chloro-2-((4-fluorobenzylimino)methyl)phenol (2) showed the most favorable antimicrobial activity with MICs of 45.2, 1.6, 2.8, 3.4, and 47.5 mu g/mL against B. subtilis, E. coli, P. fluorescence, S. aureus and A. niger, respectively. (c) 2006 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2006.11.010

文献信息

• Synthesis and antimicrobial activities of Schiff bases derived from 5-chloro-salicylaldehyde
  作者：Lei Shi、Hui-Ming Ge、Shu-Hua Tan、Huan-Qiu Li、Yong-Chun Song、Hai-Liang Zhu、Ren-Xiang Tan

  DOI：10.1016/j.ejmech.2006.11.010

  日期：2007.4

  A series of Schiff bases (compounds 1-26) were synthesized by reacting 5-chloro-salicylaldehyde and primary amines, 15 (compounds 2-4, 6, 7, 10, 12-17, 23, 25 and 26) of which were first reported. The chemical structures of these compounds were confirmed by means of H-1 NMR, C-13 NMR, ESI-MS and elemental analyses. The compounds were assayed for antibacterial (Bacillus subtilis, Escherichia coli, Pseudomonas fluorescence and Staphylococcus aureus) and antifungal (Aspergillus niger, Candida albicans and Trichophyton rubrum) activities by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl trtrazolium bromide) method. Among the compounds tested, (E)-4-chloro-2-((4-fluorobenzylimino)methyl)phenol (2) showed the most favorable antimicrobial activity with MICs of 45.2, 1.6, 2.8, 3.4, and 47.5 mu g/mL against B. subtilis, E. coli, P. fluorescence, S. aureus and A. niger, respectively. (c) 2006 Elsevier Masson SAS. All rights reserved.
• Kara, Hulya, Zeitschrift fur Naturforschung, B: Chemical Sciences, 2008, vol. 63, # 1, p. 6 - 10
  作者：Kara, Hulya

  DOI：——

  日期：——