8-Aza-2-(piperidin-4-yl)-3H-quinazolin-4-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶并嘧啶类
• 英文名称: 8-Aza-2-(piperidin-4-yl)-3H-quinazolin-4-one
• 英文别名: 2-piperidin-4-yl-3H-pyrido[2,3-d]pyrimidin-4-one
• 化学式: C₁₂H₁₄N₄O
• 分子量: 230.269
• InChiKey: JXPTZXALWKMSBS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Substituted 2-(4-piperidyl)-4(3H)-quinazolinones and 2-(4-piperidyl)- 4(3H)-azaquinazolinones
  申请人：——

  公开号：US20010051627A1

  公开（公告）日：2001-12-13

  This invention relates to compounds which are generally alpha 1A/B -receptor antagonists and which are represented by Formula I: 1 wherein the substituents are as defined in the specification; or pharmaceutically acceptable salts, hydrates, or N-oxides thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and a process for their preparation.

  本发明涉及的化合物一般为 alpha 1A/B -受体拮抗剂，由式 I 表示： 1 其中取代基如说明书中所定义；或其药学上可接受的盐、水合物或 N-氧化物。本发明还涉及含有此类化合物的药物组合物、将其用作治疗剂的方法及其制备工艺。
• US6258819B1
  申请人：——

  公开号：US6258819B1

  公开（公告）日：2001-07-10
• US6376500B2
  申请人：——

  公开号：US6376500B2

  公开（公告）日：2002-04-23
• [EN] QUINAZOLINONE AND AZAQUINAZOLINONE DERIVATIVES<br/>[FR] DERIVES DE QUINAZOLINONE ET D'AZAQUINAZOLINONE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2001010860A2

  公开（公告）日：2001-02-15

  This invention relates to compounds which are generally alpha 1A/B-receptor antagonists and which are represented by Formula (I): wherein the substituents are as defined in the specification; or pharmaceutically acceptable salts, hydrates, or N-oxides thereof. The invention further relates to pharmaceutical compositions containing such compounds, a process for their manufacture and their use as therapeutic agents.