nonane-1,1-diyldiphosphonic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: nonane-1,1-diyldiphosphonic acid
• 英文别名: nonane 1,1-diphosphonic acid；nonane-1,1-diphosphonic acid；nonylidenebisphosphonic acid；(1-Phosphono-nonyl)-phosphonic acid；1-phosphonononylphosphonic acid
• 化学式: C₉H₂₂O₆P₂
• 分子量: 288.218
• InChiKey: OZKFUXZUWPRXHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  17
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  115
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  1-氯庚烷 在 盐酸 、 magnesium 作用下， 以 四氢呋喃 为溶剂， 反应 13.0h， 生成 nonane-1,1-diyldiphosphonic acid
  参考文献：
  名称：

  Bisphosphonates derived from fatty acids are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase

  摘要：

  Studies on the mode of action of a series of bisphosphonates derived from fatty acids, which had previously proved to be potent inhibitors against Trypanosoma cruzi proliferation in in vitro assays, have been performed. Some of these drugs proved to be potent inhibitors against the intracellular form of the parasite, exhibiting IC50 values at the low micromolar level. As bisphosphonates are FDA clinically approved for treatment of bone resorption disorders, their potential innocuousness makes them good candidates to control tropical diseases. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00663-2

文献信息

• 有机膦酸类化合物的应用和钙钛矿太阳能电 池薄膜及其制备方法
  申请人：清华大学

  公开号：CN107163078B

  公开（公告）日：2019-09-17

  本发明涉及太阳能电池薄膜领域，公开了有机膦酸类化合物的应用和钙钛矿太阳能电池薄膜及其制备方法，该应用为式(1)所示的有机膦酸类化合物在制备钙钛矿太阳能电池薄膜中的应用。含有本发明的有机膦酸类化合物的钙钛矿太阳能电池薄膜具有优异的光电转化效率以及能够提高含有该薄膜的太阳能电池的光电转化效率的稳定性，同时能够避免该太阳能电池受到高温、高湿的环境的影响。
• Low phosphate detergent composition for fabric washing
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0001310A1

  公开（公告）日：1979-04-04

  A detergent composition having a phosphorous content of no more than 6 % and a solution pH of less than 10 contains an organic detergent, a carboxylate builder having a pK, of less than 9 and a small amount of a polyphosphonic acid. Typical compositions utilise a citrate or succinate builder together with ethylene diaminetetramethylene phosphonate. The compositions are particularly effective in the area of bleachable stain removal.

  一种磷含量不超过 6%、溶液 pH 值小于 10 的洗涤剂组合物含有一种有机洗涤剂、一种 pK 值小于 9 的羧酸盐促进剂和少量的多膦酸。 典型的组合物使用柠檬酸盐或琥珀酸盐促进剂以及乙烯二胺四亚甲基膦酸盐。 这种组合物在漂白去污方面特别有效。
• Detergent compositions having improved bleaching effect
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0001853A1

  公开（公告）日：1979-05-16

  A neutral to mildly alkaline detergent composition based on a particulate crystalline aluminosilicate builder and containing a low level of a polyphosphonic acid, especieily ethylene diamine tetramethylene phosphonic acid, or salt thereof. The composition exhibits excellent all-round detergency, especially for oxidizable-type stains, even in the. absance of per-bleach components.

  一种中性至弱碱性洗涤剂组合物，以微粒结晶铝硅酸盐筑底剂为基础，并含有少量的多膦酸，特别是乙二胺四亚甲基膦酸或其盐。 该组合物具有出色的全面去污能力，特别是对于可氧化型污渍，即使在不含过漂白剂成分的情况下也是如此。
• Stabilized radiographic scanning agents and method for preparing them
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0004684A2

  公开（公告）日：1979-10-17

  Stable compositions, useful as technetium-99m-based scintigraphic agents, comprise gentisic acid or a pharmaceutically-acceptable salt or ester thereof in combination with a pertechnetate reducing agent or dissolved in pertechnetate-99m (ssmTcO4) solution. The compositions are especially useful in combination with a phosphate or phosphonate material which carries the radionuclide to bone, thus providing a skeletal imaging agent.

  可用作锝-99m闪烁成像剂的稳定组合物由龙胆二酸或其药学上可接受的盐或酯与过硫酸盐还原剂结合而成，或溶于过硫酸盐-99m（ssmTcO4）溶液中。 这种组合物与磷酸盐或膦酸盐材料结合特别有用，可将放射性核素带入骨骼，从而提供骨骼成像剂。
• Anti-arthritic compositions containing gold salts and organophosphonates
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0054997A1

  公开（公告）日：1982-06-30

  Compositions comprising pharmaceutically-acceptable gold salts and organophosphonates, especially the geminal diphosphonates, useful in the treatment of arthritic conditions, are disclosed. The method of treating arthritic conditions using these compositions is also disclosed

  本发明公开了由药学上可接受的金盐和有机膦酸盐（尤其是二膦酸盐）组成的组合物，可用于治疗关节炎。还公开了使用这些组合物治疗关节炎的方法