dimethyl-[2-(2-phenethyl-2H-8-oxa-1,2-diaza-dibenzo[e,h]azulene-3-ylmethoxy)-ethyl]-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噁庚英
• 英文名称: dimethyl-[2-(2-phenethyl-2H-8-oxa-1,2-diaza-dibenzo[e,h]azulene-3-ylmethoxy)-ethyl]-amine
• 英文别名: N,N-dimethyl-2-[[4-(2-phenylethyl)-13-oxa-3,4-diazatetracyclo[12.4.0.02,6.07,12]octadeca-1(18),2,5,7,9,11,14,16-octaen-5-yl]methoxy]ethanamine
• 化学式: C₂₈H₂₉N₃O₂
• 分子量: 439.557
• InChiKey: WERLUDLNFCBUBM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  33
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  39.5
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (2-phenethyl-2H-8-oxa-1,2-diaza-dibenzo[e,h]azulene-3-yl)-methanol 、 二甲氨基氯乙烷盐酸 在 苄基三乙基氯化铵 sodium hydroxide 作用下， 以 水 、 甲苯 为溶剂， 反应 3.0h， 生成 dimethyl-[2-(2-phenethyl-2H-8-oxa-1,2-diaza-dibenzo[e,h]azulene-3-ylmethoxy)-ethyl]-amine
  参考文献：
  名称：

  [EN] 1,2-DIAZA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF
  [FR] 1,2-DIAZA-DIBENZOAZULENES UTILISES EN TANT QU'INHIBITEURS DE LA PRODUCTION DE FACTEUR DE NECROSE DES TUMEURS ET INTERMEDIAIRES PERMETTANT LA PREPARATION DE CES COMPOSES

  摘要：

  公开号：

  WO2003099822A3

文献信息

• 1,2-Diaza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
  申请人：Mercep Mladen

  公开号：US20050209296A1

  公开（公告）日：2005-09-22

  The present invention relates to derivatives of 1,2-diaza-dibenzoazulene, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory actions, especially to the inhibition of tumour necrosis factor-α (TNF-α) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.

  本发明涉及1,2-二氮杂二苯并蓝的衍生物，其药学上可接受的盐和溶剂，其制备过程和中间体，以及其抗炎作用，特别是对肿瘤坏死因子-α（TNF-α）产生的抑制和白细胞介素-1（IL-1）产生的抑制，以及其镇痛作用。
• 1,2-DIAZA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF
  申请人：GlaxoSmithKline istrazivacki centar Zagreb d.o.o.

  公开号：EP1587807B1

  公开（公告）日：2008-06-18
• USE OF 1,2-DIAZA-DIBENZO[E,H]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
  申请人：GlaxoSmithKline istrazivacki centar Zagreb d.o.o.

  公开号：EP1686989B1

  公开（公告）日：2009-01-14
• 1,2-Diaza-dibenzo[e,h]azulenes for the treatment of central nervous system diseases and disorders
  申请人：Mercep Mladen

  公开号：US20070173492A1

  公开（公告）日：2007-07-26

  The present invention relates to the use of compounds from the group of 1,2-diaza-dibenzo[e,h]azulenes and of their pharmacologically acceptable salts and solvates for the use in the treatment and prevention of diseases, damages and disorders of the central nervous system (CNS) caused by disorders of the neurochemical equilibrium of biogenic amines or other neurotransmitters.
• US7550498B2
  申请人：——

  公开号：US7550498B2

  公开（公告）日：2009-06-23