dimethyl-(4-methyl-heptyl)-amine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: dimethyl-(4-methyl-heptyl)-amine
• 英文别名: 1-Dimethylamino-4-methyl-heptan；Dimethyl-(4-methyl-heptyl)-amin；4-Methyl-n-heptyl-dimethylamin；N,N,4-trimethylheptan-1-amine
• 化学式: C₁₀H₂₃N
• 分子量: 157.299
• InChiKey: XSQJXNRSPHKFNX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  dimethyl-(4-methyl-heptyl)-amine 、 碘甲烷 在 乙醚 作用下， 生成 trimethyl-(4-methyl-heptyl)-ammonium; iodide
  参考文献：
  名称：

  Koller; Kandler, Monatshefte fur Chemie, 1931, vol. 58, p. 234

  摘要：

  DOI：
• 作为产物：
  描述：

  4-甲基-1-庚醇 在 磷化氢 、 乙醇 、 碘 作用下， 生成 dimethyl-(4-methyl-heptyl)-amine
  参考文献：
  名称：

  Koller; Kandler, Monatshefte fur Chemie, 1931, vol. 58, p. 234

  摘要：

  DOI：

文献信息

• [EN] COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS ET UTILISATIONS DE CES DERNIERS
  申请人：YUMANITY THERAPEUTICS

  公开号：WO2018081167A1

  公开（公告）日：2018-05-03

  The present invention features compounds useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.

  本发明涉及对神经系统疾病治疗中有用的化合物。本发明的化合物，单独或与其他药用活性剂结合，可用于治疗或预防神经系统疾病。
• Chemical compound, method for the production thereof and its use in catalyst systems for producing polyolefins
  申请人：——

  公开号：US20030013913A1

  公开（公告）日：2003-01-16

  The invention relates to a chemical compound of formula (I), wherein M 1 represents an element selected from main groups II, III or IV of the periodic table of elements; x is equal to 1, 2, 3 or 4; y is equal to 2, 3 or 4, and; A represents a cation of main group V of the periodic table of elements; R 1 is the same or different and represents a branched or unbranched linear or cyclic C 1 -C 40 group that contains carbon; R 2 is the same or different and represents a branched or unbranched linear or cyclic C 1 -C 40 group that contains carbon; R 3 represents a branched or unbranched linear or cyclic C 1 -C 40 group that contains carbon, and; R 4 represents a hydrogen atom; whereby R 2 and R 3 are always different from one another.

  本发明涉及一种化学式（I）的化合物，其中M1代表元素，所选自元素周期表的主要II、III或IV族；x等于1、2、3或4；y等于2、3或4，并且A代表元素周期表的主要V族的阳离子；R1相同或不同，代表含有碳的支链或直链线性或环状C1-C40基团；R2相同或不同，代表含有碳的支链或直链线性或环状C1-C40基团；R3代表含有碳的支链或直链线性或环状C1-C40基团，且R4代表氢原子；其中R2和R3始终彼此不同。
• GAMMA-DIKETONES AS WNT/BETA-CATENIN SIGNALLING PATHWAY ACTIVATORS
  申请人：Samumed, LLC

  公开号：EP3456325A2

  公开（公告）日：2019-03-20

  The present disclosure provides γ-diketones or analogs thereof, that activate Wnt/β-catenin signaling and thus treat or prevent diseases related to signal transduction, such as osteoporosis and osteoarthropathy; osteogenesis imperfecta, bone defects, bone fractures, periodontal disease, otosclerosis, wound healing, craniofacial defects, oncolytic bone disease, traumatic brain injuries or spine injuries, brain atrophy/neurological disorders related to the differentiation and development of the central nervous system, including Parkinson's disease, strokes, ischemic cerebral disease, epilepsy, Alzheimer's disease, depression, bipolar disorder, schizophrenia; otic disorders like cochlear hair cell loss; eye diseases such as age related macular degeneration, diabetic macular edema or retinitis pigmentosa and diseases related to differentiation and growth of stem cell, such as hair loss, hematopoiesis related diseases and tissue regeneration related diseases.

  本公开提供了γ-二酮或其类似物，它们能激活Wnt/β-catenin信号转导，从而治疗或预防与信号转导有关的疾病，如骨质疏松症和骨关节病；成骨不全症、骨缺损、骨折、牙周病、耳硬化症、伤口愈合、颅面缺损、溶瘤性骨病、脑外伤或脊柱损伤、脑萎缩/与中枢神经系统分化和发育有关的神经系统疾病，包括帕金森病、中风、缺血性脑病、癫痫、阿尔茨海默病、抑郁症、躁狂症、精神分裂症；耳部疾病，如耳蜗毛细胞缺失；眼部疾病，如老年性黄斑变性、糖尿病性黄斑水肿或视网膜色素变性；以及与干细胞分化和生长有关的疾病，如脱发、造血相关疾病和组织再生相关疾病。
• Chemical products suited for use as co-catalysts, method for the preparation thereof and their use in catalyst systems for producing polyolefins
  申请人：——

  公开号：US20030144434A1

  公开（公告）日：2003-07-31

  The invention relates to chemical products which are suited for use as co-catalysts and which can be obtained by reacting a compound of formula (I), M 1 R 1 R 2 (R 3 ) m with a compound of formula (II), (R 4 X) q -(G)*(M 2 R 5 R 6 ) g . In formula (I), R 1 , R 2 and R 3 are the same or different and represent a hydrogen atom, C 1 -C 20 alkyl, C 1 -C 20 alkyl halide, C 6 -C 20 aryl, C 6 -C 20 aryl halide, C 7 -C 40 arylalkyl, C 7 -C 40 arylalkyl halide, C 7 -C 40 alkylaryl or C 7 -C 40 alkylaryl halide; M 1 represents an element of the second or third main group of the periodic table of elements, and; m equals 0 or 1, whereby m is equal to 1 when M 1 represents an element of the third main group, and m is equal to 0 when M 1 represents an element of the second main group. In formula (II), substituents R 4 X, which contain hetero atoms, is located on a base body G, and: groups R 4 are the same or different and represent hydrogen, C 1 -C 20 alkyl, C 1 -C 20 alkyl halide, C 6 -C 20 aryl, C 6 -C 20 aryl halide, C 7 -C 40 arylalkyl, C 7 -C 40 arylalkyl halide, C 7 -C 40 akylaryl or C 7 -C 40 alkylaryl halide; X represents an element of the fourth, fifth or sixth main group of the periodic table of elements; G represents at least bivalent C 1 -C 20 alkylene, C 1 -C 20 alkylene halide, C 1 -C 10 alkylenoxy, C 6 -C 40 arylene, C 6 -C 40 arylene halide, C 6 -C 40 arylenoxy, C 7 -C 40 arylalkylene, C 7 -C 40 arylalkylene halide, C 7 -C 40 alkylarylene, C 7 -C 40 alkylarylene halide; M 2 represents an element of the fourth, fifth or sixth main group of the periodic table of elements; R 5 and R 6 , independent of one another, are the same or different and represent a hydrogen atom, C 1 -C 20 alkyl, C 1 -C 10 alkoxy, C 2 -C 10 alkenyl, C 7 -C 20 arylalkyl, C 7 -C 20 alkylaryl, C 6 -C 10 aryloxy, C 1 -C 10 alkyl halide; q is a whole number ranging from 2 to 100, and; g is a whole number ranging from 1 to 100. The invention also relates to a method for preparing the inventive chemical products, and to their use in catalyst systems for producing polyolefins.

  本发明涉及适合用作助催化剂的化学产品，这些产品可通过使式（I）化合物、M 1 R 1 R 2 (R 3 ) m 与式(II)化合物，(R 4 X) q -(G)*(M 2 R 5 R 6 ) g .在式 (I) 中，R 1 , R 2 和 R 3 相同或不同，代表氢原子、C 1 -C 20 烷基、C 1 -C 20 烷基卤化物，C 6 -C 20 芳基，C 6 -C 20 芳基卤化物，C 7 -C 40 芳烷基，C 7 -C 40 芳烷基卤化物，C 7 -C 40 烷芳基或 C 7 -C 40 烷芳基卤化物；M 1 代表元素周期表中第二或第三主族的元素，并且；m 等于 0 或 1，其中当 M 1 代表第三主族元素时，m 等于 1，而当 M 1 代表第二主族元素时，m 等于 0。在式 (II) 中，取代基 R 4 X 含有杂原子，位于基体 G 上，以及：基团 R 4 相同或不同，代表氢、C 1 -C 20 烷基、C 1 -C 20 烷基卤化物，C 6 -C 20 芳基，C 6 -C 20 芳基卤化物，C 7 -C 40 芳烷基，C 7 -C 40 芳烷基卤化物，C 7 -C 40 芳烷基或 C 7 -C 40 烷基芳基卤化物； X 代表元素周期表中第四、第五或第六主族的元素； G 代表至少二价 C 1 -C 20 烯烃、C 1 -C 20 卤化烯，C 1 -C 10 烷基苯氧基，C 6 -C 40 芳烯，C 6 -C 40 芳烃卤化物，C 6 -C 40 芳烯氧基，C 7 -C 40 芳基烯烃，C 7 -C 40 芳基烷烃卤化物，C 7 -C 40 芳基烷烃，C 7 -C 40 烷芳基卤化物；M 2 代表元素周期表中第四、第五或第六主族的元素； R 5 和 R 6 代表氢原子、C 1 -C 20 烷基、C 1 -C 10 烷氧基、C 2 -C 10 烯基、C 7 -C 20 芳烷基，C 7 -C 20 烷芳基、C 6 -C 10 芳氧基，C 1 -C 10 烷基卤化物； q 是 2 至 100 之间的整数； g 是 1 至 100 之间的整数。 1 至 100 的整数。本发明还涉及制备本发明化学产品的方法及其在生产聚烯烃的催化剂体系中的用途。
• CHEMISCHE VERBINDUNG, VERFAHREN ZU DEREN HERSTELLUNG UND DEREN VERWENDUNG IN KATALYSATORSYSTEMEN ZUR HERSTELLUNG VON POLYOLEFINEN
  申请人：Basell Polyolefine GmbH

  公开号：EP1250363A2

  公开（公告）日：2002-10-23