((S)-2,2-Dimethyl-1-p-tolylsulfanylmethyl-propyl)-(3,5-dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-methyl-amine

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: ((S)-2,2-Dimethyl-1-p-tolylsulfanylmethyl-propyl)-(3,5-dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-methyl-amine
• 英文别名: N-[(2S)-3,3-dimethyl-1-(4-methylphenyl)sulfanylbutan-2-yl]-N-methyl-12,14-dioxa-13-phosphapentacyclo[13.8.0.02,11.03,8.018,23]tricosa-1(15),2(11),3,5,7,9,16,18,20,22-decaen-13-amine
• 化学式: C₃₄H₃₄NO₂PS
• 分子量: 551.689
• InChiKey: MWVQULYVBTTZDJ-WJOKGBTCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.5
• 重原子数：
  39
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  54.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  [(2S)-2-(tert-butoxycarbonylamino)-3,3-dimethyl-butyl] methanesulfonate 在 lithium aluminium tetrahydride 、 三乙胺 、 三氯化磷 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 生成 ((S)-2,2-Dimethyl-1-p-tolylsulfanylmethyl-propyl)-(3,5-dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-methyl-amine
  参考文献：
  名称：

  Design and synthesis of new bidentate phosphoramidite ligands for enantioselective copper-catalyzed conjugate addition of diethylzinc to enones

  摘要：

  Several thioaryl- and phosphino-phosphoramidite ligands have been synthesized from commercially available beta-aminoalcohols. This new family of bidentate ligands are highly active in the enantioselective copper-catalyzed conjugate addition of diethylzinc to both cyclic and acyclic enones showing moderate to good enantiomeric excesses of up to 81%. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2006.10.029

文献信息

• Design and synthesis of new bidentate phosphoramidite ligands for enantioselective copper-catalyzed conjugate addition of diethylzinc to enones
  作者：Fabien Boeda、Diane Rix、Hervé Clavier、Christophe Crévisy、Marc Mauduit

  DOI：10.1016/j.tetasy.2006.10.029

  日期：2006.10

  Several thioaryl- and phosphino-phosphoramidite ligands have been synthesized from commercially available beta-aminoalcohols. This new family of bidentate ligands are highly active in the enantioselective copper-catalyzed conjugate addition of diethylzinc to both cyclic and acyclic enones showing moderate to good enantiomeric excesses of up to 81%. (c) 2006 Elsevier Ltd. All rights reserved.