2-Diethylamino-3,3-dimethyl-buten-(1)

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-Diethylamino-3,3-dimethyl-buten-(1)
• 英文别名: N,N-diethyl-3,3-dimethylbut-1-en-2-amine
• 化学式: C₁₀H₂₁N
• 分子量: 155.283
• InChiKey: ZGQHKNYTZXGWOC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  频哪酮 、 (N,N-diethylamino)tributyltin 生成 2-Diethylamino-3,3-dimethyl-buten-(1)
  参考文献：
  名称：

  Réactions du diéthylaminotributylétain avec certaines cétones cyclaniques et aliphatiques

  摘要：

  DOI：

  10.1016/s0022-328x(00)81096-7

文献信息

• [EN] CALPAIN MODULATORS AND METHODS OF PRODUCTION AND USE THEREOF<br/>[FR] MODULATEURS DE CALPAÏNE ET LEURS MÉTHODES DE PRODUCTION ET D'UTILISATION
  申请人：BLADE THERAPEUTICS INC

  公开号：WO2017156074A1

  公开（公告）日：2017-09-14

  The present technology relates to compounds, kits, compositions, and methods useful for the treatment of fibrotic disease. In some aspects, the present technology provides for treatment of various diseases or disorders associated or mediated, at least in part, by calpains, such as CAPN1, CAPN2, and/or CAPN9. The present technology is generally applicable to compounds which inhibit myofibroblast differentiation.

  这项技术涉及到用于治疗纤维化疾病的化合物、试剂盒、组合物和方法。在某些方面，这项技术提供了治疗与卡尔帕因（如CAPN1、CAPN2和/或CAPN9）至少部分相关或介导的各种疾病或疾病的方法。这项技术通常适用于抑制肌成纤维细胞分化的化合物。
• Novel cc-1065 Analogs and Their Conjugates
  申请人：Beusker Patrick Henry

  公开号：US20110207767A1

  公开（公告）日：2011-08-25

  This invention relates to novel analogs of the DNA-alkylating agent CC-1065 and to their conjugates. Furthermore this invention concerns intermediates for the preparation of said agents and conjugates. The conjugates are designed to release their (multiple) payload after one or more activation steps and/or at a rate and time span controlled by the conjugate in order to selectively deliver and/or controllably release one or more of said DNA alkylating agents. The agents, conjugates, and intermediates can be used to treat an illness that is characterized by undesired (cell) proliferation. As an example, the agents and the conjugates of this invention may be used to treat a tumor.
• NOVEL INDENE DERIVATIVE, PREPARATION METHOD FOR SAME, AND PHARMACEUTICAL COMPOSITION, FOR PREVENTING OR TREATING RETINAL DISEASES, CONTAINING SAME AS ACTIVE INGREDIENT
  申请人：THE INDUSTRY & ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY (IAC)

  公开号：US20170152268A1

  公开（公告）日：2017-06-01

  The present invention relates to a novel indene derivative, a preparation method for the same, and a pharmaceutical composition for preventing or treating retinal disease comprising the same as an active ingredient. The novel indene derivative of the present invention, the optical isomer of the same, or the pharmaceutically acceptable salts of the same have excellent inhibitory efficiency of receptor-interacting serine/threonine-protein kinase 1 (RIPK1). Therefore, the composition containing the same as an active ingredient can be effectively used as a pharmaceutical composition for preventing or treating retinal disease exemplified by retinitis pigmentosa (RP), Leber congenital amaurosis (LCA), Stargardts disease, Usher syndrome, choroideremia, rod-cone or cone-rod dystrophy, ciliopathy, mitochondrial disorders, progressive retinal atrophy, degenerative retinal diseases, age-related macular degeneration (AMD), wet AMD, dry AMD, geographical atrophy, inherited or acquired macular degeneration, retinal photoreceptor diseases, retinal pigment epithelial diseases, diabetic retinopathy, cystic macular edema, uveitis, retinal detachment, traumatic retinal injury, iatrogenic retinal injury, macular holes, macular capillarectasia, ganglion cell diseases, optic nerve diseases, glaucoma, optic neuropathy, ischemic retinal diseases, retinopathy of prematurity, occlusion of retinal vessels, inherited macroaneurysm, retinal vascular diseases, ophthalmic vascular diseases, glaucomatous retinal neurodegeneration, ischemic optic neuropathy and the like.
• US7498441B2
  申请人：——

  公开号：US7498441B2

  公开（公告）日：2009-03-03
• Réactions du diéthylaminotributylétain avec certaines cétones cyclaniques et aliphatiques
  作者：Jean-Claude Pommier、André Roubineau

  DOI：10.1016/s0022-328x(00)81096-7

  日期：1969.2