哌啶戊醇 | 2937-83-9

• 物质功能分类: 生物 - 细胞培养 - 添加剂
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 哌啶戊醇
• 中文别名: 1-(5-羟基戊基)哌啶
• 英文名称: 5-(1-piperidyl)-1-pentanol
• 英文别名: 5-piperidino-1-pentanol；piperidino-5-pentanol-1；5-piperidin-1-yl-pentan-1-ol；5-piperidino-pentan-1-ol；5-(1-piperidinyl)pentanol；5-Piperidino-pentanol-(1)；1-Piperidinepentanol；5-piperidin-1-ylpentan-1-ol
• CAS: 2937-83-9
• 化学式: C₁₀H₂₁NO
• 分子量: 171.283
• InChiKey: GEPOCRCIIKQXSM-UHFFFAOYSA-N

物化性质

• 沸点：
  140 °C / 13mmHg
• 密度：
  0.94
• 稳定性/保质期：
  遵照规定使用和储存，则不会分解。

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2933399090

SDS

1-Piperidinepentanol Revision number: 5
SAFETY DATA SHEET

---

Section 1. IDENTIFICATION
Product name: 1-Piperidinepentanol

Revision number: 5

---

Section 2. HAZARDS IDENTIFICATION
GHS classification
PHYSICAL HAZARDS Not classified
HEALTH HAZARDS
Skin corrosion/irritation Category 2
Category 2A
Serious eye damage/eye irritation
ENVIRONMENTAL HAZARDS Not classified
GHS label elements, including precautionary statements
Pictograms or hazard symbols
Signal word Warning
Hazard statements Causes skin irritation
Causes serious eye irritation
Precautionary statements:
Wash hands thoroughly after handling.
[Prevention]
Wear protective gloves/eye protection/face protection.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses,
[Response]
if present and easy to do. Continue rinsing.
If eye irritation persists: Get medical advice/attention.
IF ON SKIN: Gently wash with plenty of soap and water.
If skin irritation occurs: Get medical advice/attention.
Take off contaminated clothing and wash before reuse.

---

Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
Substance/mixture: Substance
Components: 1-Piperidinepentanol
Percent: >97.0%(GC)(T)
CAS Number: 2937-83-9
Synonyms: 1-(5-Hydroxypentyl)piperidine
C10H21NO
Chemical Formula:

---

Section 4. FIRST AID MEASURES
Inhalation: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
Get medical advice/attention if you feel unwell.
1-Piperidinepentanol

---

Section 4. FIRST AID MEASURES
Skin contact: Remove/Take off immediately all contaminated clothing. Gently wash with plenty of
soap and water. If skin irritation or rash occurs: Get medical advice/attention.
Eye contact: Rinse cautiously with water for several minutes. Remove contact lenses, if present
and easy to do. Continue rinsing. If eye irritation persists: Get medical
advice/attention.
Ingestion: Get medical advice/attention if you feel unwell. Rinse mouth.
A rescuer should wear personal protective equipment, such as rubber gloves and air-
Protection of first-aiders:
tight goggles.

---

Section 5. FIRE-FIGHTING MEASURES
Suitable extinguishing Dry chemical, foam, carbon dioxide.
media:
Unsuitable extinguishing Water (It may scatter and spread fire.)
media:
Specific hazards arising Take care as it may decompose upon combustion or in high temperatures to
from the chemical: generate poisonous fume.
Precautions for firefighters: Fire-extinguishing work is done from the windward and the suitable fire-extinguishing
method according to the surrounding situation is used. Uninvolved persons should
evacuate to a safe place. In case of fire in the surroundings: Remove movable
containers if safe to do so.
Special protective When extinguishing fire, be sure to wear personal protective equipment.
equipment for firefighters:

---

Section 6. ACCIDENTAL RELEASE MEASURES
Personal precautions, Use personal protective equipment. Keep people away from and upwind of spill/leak.
protective equipment and Ensure adequate ventilation. Entry to non-involved personnel should be controlled
emergency procedures: around the leakage area by roping off, etc.
Environmental precautions: Prevent product from entering drains.
Methods and materials for Absorb spilled material in a suitable absorbent (e.g. rag, dry sand, earth, saw-dust).
containment and cleaning In case of large amount of spillage, contain a spill by bunding. Adhered or collected
up: material should be promptly disposed of, in accordance with appropriate laws and
regulations.

---

Section 7. HANDLING AND STORAGE
Precautions for safe handling
Technical measures: Handling is performed in a well ventilated place. Wear suitable protective equipment.
Prevent generation of vapour or mist. Wash hands and face thoroughly after
handling.
Use a ventilation, local exhaust if vapour or aerosol will be generated.
Advice on safe handling: Avoid contact with skin, eyes and clothing.
Conditions for safe storage, including any
incompatibilities
Storage conditions: Keep container tightly closed. Store in a cool and dark place.
Store away from incompatible materials such as oxidizing agents.
Comply with laws.
Packaging material:

---

Section 8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Engineering controls: Install a closed system or local exhaust as possible so that workers should not be
exposed directly. Also install safety shower and eye bath.
Personal protective equipment
Respiratory protection: Vapor respirator. Follow local and national regulations.
Hand protection: Protective gloves.
Safety glasses. A face-shield, if the situation requires.
Eye protection:
Skin and body protection: Protective clothing. Protective boots, if the situation requires.
1-Piperidinepentanol

---

Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Physical state (20°C): Liquid
Form: Clear
Colorless - Reddish yellow
Colour:
Odour: No data available
pH: No data available
Melting point/freezing point:No data available
140°C/1.7kPa
Boiling point/range:
Flash point: No data available
Flammability or explosive
limits:
No data available
Lower:
Upper: No data available
0.94
Relative density:
Solubility(ies):
No data available
[Water]
[Other solvents] No data available

---

Section 10. STABILITY AND REACTIVITY
Chemical stability: Stable under proper conditions.
Possibility of hazardous No special reactivity has been reported.
reactions:
Incompatible materials: Oxidizing agents
Hazardous decomposition Carbon monoxide, Carbon dioxide, Nitrogen oxides (NOx)
products:

---

Section 11. TOXICOLOGICAL INFORMATION
Acute Toxicity: No data available
Skin corrosion/irritation: No data available
Serious eye No data available
damage/irritation:
Germ cell mutagenicity: No data available
Carcinogenicity:
IARC = No data available
No data available
NTP =
Reproductive toxicity: No data available

---

Section 12. ECOLOGICAL INFORMATION
Ecotoxicity:
Fish: No data available
Crustacea: No data available
Algae: No data available
Persistence / degradability: No data available
Bioaccumulative No data available
potential(BCF):
Mobility in soil
Log Pow: No data available
Soil adsorption (Koc): No data available
Henry's Law No data available
constant(PaM3/mol):

---

Section 13. DISPOSAL CONSIDERATIONS
Recycle to process, if possible. Consult your local regional authorities. You may be able to burn in a chemical
incinerator equipped with an afterburner and scrubber system. Observe all federal, state and local regulations when
disposing of the substance.
1-Piperidinepentanol

---

Section 14. TRANSPORT INFORMATION
Hazards Class: Does not correspond to the classification standard of the United Nations
UN-No: Not listed

---

Section 15. REGULATORY INFORMATION
Safe management ordinance of dangerous chemical product (State Council announces on January 26, 2002
and revised on February 16,2011): Safe use and production, the storage of a dangerous chemical, transport,
loading and unloading were prescribed.

---

SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  哌啶戊醇 在 氯化亚砜 、 氯仿 作用下， 生成 1-(5-chloropentyl)piperidine hydrochloride
  参考文献：
  名称：

  The Preparation and Properties of Some ι-(N,N-Dialkylamino) Alkyl-3-thienyl Sulfide Hydrochlorides¹

  摘要：

  DOI：

  10.1021/ja01105a015
• 作为产物：
  描述：

  戊二酸单乙酯酰氯 在 lithium aluminium tetrahydride 、 乙醚 作用下， 生成 哌啶戊醇
  参考文献：
  名称：

  Avison, Journal of Applied Chemistry, 1951, vol. 1, p. 469,470

  摘要：

  DOI：
• 作为试剂：
  描述：

  哌啶戊醇 、 4-chloro-6-(4-fluorophenyl)-2-methylpyrimidine 在 哌啶戊醇 作用下， 生成 NS-7
  参考文献：
  名称：

  Heterocyclic derivative and medicine

  摘要：

  一种药物组合物，包括以下通式［I］或其盐的化合物。其中R1代表芳基或杂芳基基团。R2代表氢、烷基、烯基、环烷基、环烷基烷基、羟基烷基、卤代烷基、烷氧基、烷硫基、氨基、单烷基氨基、双烷基氨基或苯基。R3和R4独立地代表氢或烷基，或R3和R4与相邻的N原子结合形成5-至7-成员的环氨基团。A代表单键的C2-10烷基。W代表O、S或（CH2）n（其中CH可以被烷基取代；n是1或2的整数）。X、Y和Z可以相同或不同，每个代表CH（可以被烷基取代）或N。然而，不包括X、Y和Z同时代表CH的情况。该发明的化合物具有出色的神经元死亡抑制活性，并可用作治疗脑血管疾病的治疗药物。

  公开号：

  US06191149B1

文献信息

• Derivatives of pyrimidine for treating acute cerebrovascular disorders
  申请人：Nippon Shinyaku Co., Ltd.

  公开号：US05945426A1

  公开（公告）日：1999-08-31

  A pharmaceutical composition comprising a compound of the following general formula \x9bI! or its salt. ##STR1## wherein R.sup.1 represents aryl or a heteroaromatic group. R.sup.2 represents hydrogen, alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, hydroxyalkyl, haloalkyl, alkoxy, alkylthio, amino, monoalkylamino, dialkylamino, or phenyl. R.sup.3 and R.sup.4 independently represent hydrogen or alkyl or R.sup.3 and R.sup.4 taken together with the adjacent N atom represent a 5- through 7-membered cyclic amino group. A represents C.sub.2-10 alkylene. W represents O, S, or (CH).sub.n (where CH may be substituted by alkyl; n is an integer of 1 or 2). X, Y, and Z may be the same or different and each represents CH (which may be substituted by alkyl), or N. Provided, however, that the case in which X, Y, and Z concurrently represent CH is excluded. The compound of the invention has excellent neuronal death inhibitory activity and is useful as a therapeutic drug for cerebrovascular diseases.

  一种药物组合物，包含以下通式I所示的化合物或其盐： ##STR1## 其中，R1代表芳基或杂芳香族基团；R2代表氢、烷基、烯基、环烷基、环烷基烷基、羟烷基、卤代烷基、烷氧基、烷硫基、氨基、单烷基氨基、二烷基氨基或苯基；R3和R4独立地代表氢或烷基，或者R3和R4与相邻的N原子一起代表5至7元环状氨基基团；A代表C2-10亚烷基；W代表O、S或(CH)n（其中CH可被烷基取代；n为1或2的整数）；X、Y和Z可以相同或不同，各自代表CH（可被烷基取代）或N。但X、Y和Z同时代表CH的情况除外。本发明的化合物具有优异的神经元死亡抑制活性，可作为治疗脑血管疾病的药物。
• Fused bicyclic amide compounds and medicinal use thereof
  申请人：——

  公开号：US20030203909A1

  公开（公告）日：2003-10-30

  The present invention provides a compound represented by the formula (I) 1 wherein ring A is benzene, cyclohexane, pyridine, piperidine or a derivative thereof, imidazole or a derivative thereof and the like, ring B is benzene, cyclohexane, pyrrole or a derivative thereof, furan, thiophene and the like, R 1 , R 2 and R 3 are each hydrogen, alkyl, halogen, hydroxyl group, alkoxy and the like, W is hydrogen, alkyl or hydroxycarbonylalkyl, X is halogen, cyano, nitro and the like, X′ is hydrogen, halogen and the like, and Y is alkyl, hydroxyalkyl, hydroxycarbonylalkyl, aminoalkyl and the like, a salt thereof, and a pharmaceutical agent containing the compound. The compound of the present invention shows a superior inhibitory effect on the proliferation of activated lymphocyte and is useful as an agent for the prophylaxis or treatment of various autoimmune diseases.

  本发明提供了一种由以下化学式（I）1所代表的化合物，其中环A为苯、环己烷、吡啶、哌啶或其衍生物、咪唑或其衍生物等，环B为苯、环己烷、吡咯或其衍生物、呋喃、噻吩等，R1、R2和R3分别为氢、烷基、卤素、羟基、烷氧基等，W为氢、烷基或羟基羰基烷基，X为卤素、氰基、硝基等，X′为氢、卤素等，Y为烷基、羟基烷基、羟基羰基烷基、氨基烷基等，其盐和含有该化合物的药物。本发明的化合物对活化淋巴细胞的增殖具有优越的抑制作用，并可用作各种自身免疫性疾病的预防或治疗剂。
• PROCESS FOR PREPARING (METH)ACRYLIC ACID
  申请人：Vogel Bernd

  公开号：US20100029979A1

  公开（公告）日：2010-02-04

  The present invention relates to a process for preparing (meth)acrylic acid, characterized in that a cyclic ester is converted to (meth)acrylic acid in the presence of a catalyst. The (meth)acrylic acid prepared can in particular be converted to (meth)acrylates.

  本发明涉及一种制备（甲基）丙烯酸的方法，其特征在于在催化剂的存在下将环状酯转化为（甲基）丙烯酸。制备的（甲基）丙烯酸可以特别地转化为（甲基）丙烯酸酯。
• PROCESS FOR PREPARING TETRAMETHYL GLYCOLIDE
  申请人：Vogel Bernd

  公开号：US20100010276A1

  公开（公告）日：2010-01-14

  The present invention relates to a process for preparing tetramethylglycolide by heating a composition which comprises at least 50% by weight of 2-hydroxy-isobutyric acid and/or tetramethylglycolide to a temperature of at least 100° C.

  本发明涉及一种制备四甲基乙二酰乙酯的方法，包括将含有至少50%重量的2-羟基异丁酸和/或四甲基乙二酰乙酯的组合物加热至至少100℃的温度。
• Method for preventing or treating neurologic damage after spinal cord injury
  申请人：Kazui Teruhisa

  公开号：US20070021451A1

  公开（公告）日：2007-01-25

  The present invention provides a method for preventing and/or treating neurologic damage after spinal cord injury in a mammal including human in need thereof which comprises administering an effective amount of a compound of the general formula [I]: or a salt, or a solvate thereof, and a use thereof.

  本发明提供了一种预防和/或治疗哺乳动物，包括需要的人类，在脊髓损伤后神经损伤的方法，其包括给予一定量的一般式[I]的化合物或其盐、溶剂化物的有效量，以及其用途。

表征谱图