1-(5-chloropentyl)piperidine hydrochloride | 91976-94-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-(5-chloropentyl)piperidine hydrochloride
• 英文别名: 1-(5-chloro-pentyl)-piperidine; hydrochloride；1-(5-Chlor-pentyl)-piperidin; Hydrochlorid；1-(5-chloropentyl)piperidine;hydrochloride
• CAS: 91976-94-2
• 化学式: C₁₀H₂₀ClN*ClH
• mdl: MFCD18483304
• 分子量: 226.189
• InChiKey: QGNSAPOYVCDCFF-UHFFFAOYSA-N

物化性质

• 熔点：
  138.5-140 °C

计算性质

• 辛醇/水分配系数(LogP)：
  2.73
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-(5-chloropentyl)piperidine hydrochloride 在 sodium azide 、 potassium iodide 作用下， 以 水 为溶剂， 反应 72.0h， 以85%的产率得到1-(5-azidopentyl)piperidine
  参考文献：
  名称：

  First Metal-Containing Histamine H₃ Receptor Ligands

  摘要：

  Iron-containing ligands targeting the human histamine H-3 receptor (hH(3)R) were prepared. The compounds contain ferrocene sandwich complexes coupled via different linkers to a basic hH(3)R antagonist/inverse agonist pharmacophore. In a click chemistry approach, a triazole was successfully inserted as a new linking element. Two ferrocenylmethylamines and a ferrocenyltriazole were the most affine hH(3)R ligands within this series, showing receptor binding in the nano- and subnanomolar concentration range.

  DOI：

  10.1021/ol100419y
• 作为产物：
  描述：

  哌啶戊醇 在 氯化亚砜 、 氯仿 作用下， 生成 1-(5-chloropentyl)piperidine hydrochloride
  参考文献：
  名称：

  The Preparation and Properties of Some ι-(N,N-Dialkylamino) Alkyl-3-thienyl Sulfide Hydrochlorides¹

  摘要：

  DOI：

  10.1021/ja01105a015

文献信息

• Multitarget‐Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H ₃ R Antagonism for Neurodegenerative Diseases
  作者：Óscar M. Bautista‐Aguilera、Stefanie Hagenow、Alejandra Palomino‐Antolin、Víctor Farré‐Alins、Lhassane Ismaili、Pierre‐Louis Joffrin、María L. Jimeno、Ondřej Soukup、Jana Janočková、Lena Kalinowsky、Ewgenij Proschak、Isabel Iriepa、Ignacio Moraleda、Johannes S. Schwed、Alejandro Romero Martínez、Francisco López‐Muñoz、Mourad Chioua、Javier Egea、Rona R. Ramsay、José Marco‐Contelles、Holger Stark

  DOI：10.1002/anie.201706072

  日期：2017.10.2

  of multitarget‐directed drugs (MTDs). Novel indole derivatives with inhibitory activity towards acetyl/butyrylcholinesterases and monoamine oxidases A/B as well as the histamine H3 receptor (H3R) were obtained by optimization of the neuroprotectant ASS234 by incorporating generally accepted H3R pharmacophore motifs. These small‐molecule hits demonstrated balanced activities at the targets, mostly in

  复杂的神经退行性疾病的治疗需要开发多靶标定向药物（MTD）。通过掺入普遍接受的H3R药效基团来优化神经保护剂ASS234，可获得对乙酰基/丁酰胆碱酯酶和单胺氧化酶A / B以及组胺H 3受体（H3R）具有抑制活性的新型吲哚衍生物。这些小分子命中物显示了在靶标上的平衡活性，主要是在纳摩尔浓度范围内。其他体外研究显示抗氧化神经保护作用以及穿透血脑屏障的能力。有了这种有前途的体外研究，辅助剂（1 mg kg -1 ip）可以显着改善脂多糖引起的认知功能障碍。
• Estrogen receptor ligands. Part 16: 2-Aryl indoles as highly subtype selective ligands for ERα
  作者：Kevin D. Dykstra、Liangqin Guo、Elizabeth T. Birzin、Wanda Chan、Yi Tien Yang、Edward C. Hayes、Carolyn A. DaSilva、Lee-Yuh Pai、Ralph T. Mosley、Bryan Kraker、Paula M.D. Fitzgerald、Frank DiNinno、Susan P. Rohrer、James M. Schaeffer、Milton L. Hammond

  DOI：10.1016/j.bmcl.2007.01.054

  日期：2007.4

  A novel class of indole ligands for estrogen receptor alpha have been discovered which exhibit potent affinity and high selectivity. Substitution of the bazedoxifene skeleton to the linker present in the HTS lead 1a provided 22b which was found to be 130-fold alpha-selective and acted as an antagonist of estradiol activity in uterine tissue and MCF-7 cancer cells.
• Aminoalkylthienyl sulfides and method of preparing
  申请人：DAVID SCHUETZ ROBERT

  公开号：US02768165A1

  公开（公告）日：1956-10-23
• US4473704A
  申请人：——

  公开号：US4473704A

  公开（公告）日：1984-09-25
• US4920221A
  申请人：——

  公开号：US4920221A

  公开（公告）日：1990-04-24