ethyl 3-aminomethylfuran-2-carboxylate hydrochloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃
• 英文名称: ethyl 3-aminomethylfuran-2-carboxylate hydrochloride
• 英文别名: Ethyl 3-(aminomethyl)-2-furoate；ethyl 3-(aminomethyl)furan-2-carboxylate;hydrochloride
• 化学式: C₈H₁₁NO₃*ClH
• 分子量: 205.641
• InChiKey: NLSQQODMRQBDSD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.34
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  65.5
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ethyl 3-aminomethylfuran-2-carboxylate hydrochloride 在 sodium hydroxide 、 盐酸 作用下， 以 乙醇 为溶剂， 反应 3.0h， 以63%的产率得到3-Aminomethyl-furan-2-carboxylic acid hydrochloride
  参考文献：
  名称：

  Reactions of alkyl (halomethyl)furancarboxylates with hexamethylenetetramine

  摘要：

  All isomers of (aminomethyl)furancarboxylic acids were prepared by the Delepine reaction from alkyl (halomethyl)furancarboxylates. Treatment of the initially formed quaternary salt with an ethanolic HCl solution yielded the salts of the corresponding unstable amino acid esters. A procedure for their purification to a high degree of purity was developed. Hydrolysis of the crude esters yielded stable amino acid salts.

  DOI：

  10.1134/s1070363206080251
• 作为产物：
  描述：

  3-(溴甲基)-2-糠酸甲酯 在 盐酸 作用下， 以 氯仿 为溶剂， 反应 8.0h， 生成 ethyl 3-aminomethylfuran-2-carboxylate hydrochloride
  参考文献：
  名称：

  Reactions of alkyl (halomethyl)furancarboxylates with hexamethylenetetramine

  摘要：

  All isomers of (aminomethyl)furancarboxylic acids were prepared by the Delepine reaction from alkyl (halomethyl)furancarboxylates. Treatment of the initially formed quaternary salt with an ethanolic HCl solution yielded the salts of the corresponding unstable amino acid esters. A procedure for their purification to a high degree of purity was developed. Hydrolysis of the crude esters yielded stable amino acid salts.

  DOI：

  10.1134/s1070363206080251

文献信息

• Reactions of alkyl (halomethyl)furancarboxylates with hexamethylenetetramine
  作者：I. M. Lapina、L. M. Pevzner、A. A. Potekhin

  DOI：10.1134/s1070363206080251

  日期：2006.8

  All isomers of (aminomethyl)furancarboxylic acids were prepared by the Delepine reaction from alkyl (halomethyl)furancarboxylates. Treatment of the initially formed quaternary salt with an ethanolic HCl solution yielded the salts of the corresponding unstable amino acid esters. A procedure for their purification to a high degree of purity was developed. Hydrolysis of the crude esters yielded stable amino acid salts.