4-chloro-7-[(diethylcarbamoyl)oxy]-6-phenylpyrrolo[2,1-d][1,5]benzothiazepine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并硫氮卓类
• 英文名称: 4-chloro-7-[(diethylcarbamoyl)oxy]-6-phenylpyrrolo[2,1-d][1,5]benzothiazepine
• 英文别名: (4-chloro-6-phenylpyrrolo[2,1-d][1,5]benzothiazepin-7-yl) N,N-diethylcarbamate
• 化学式: C₂₃H₂₁ClN₂O₂S
• 分子量: 424.951
• InChiKey: HSRQSEDFOWLSEN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  59.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N,N-二乙基氯甲酰胺 、 (+/-)-4-chloro-6-phenylpyrrolo<2,1-d><1,5>benzothiazepin-7(6H)-one 在 potassium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 8.0h， 以61%的产率得到4-chloro-7-[(diethylcarbamoyl)oxy]-6-phenylpyrrolo[2,1-d][1,5]benzothiazepine
  参考文献：
  名称：

  New pyrrolobenzothiazepine derivatives as molecular probes of the ‘peripheral-type’ benzodiazepine receptor (PBR) binding site

  摘要：

  A number of new pyrrolobenzothiazepine derivatives and a pyrrolobenzothiazocine derivative have been synthesized and evaluated for their affinity towards the 'peripheral-type' benzodiazepine receptor (PER). The new compounds were tested in rat cortex, a tissue expressing a high density of mitochondrial PER. Some of the pyrrolobenzothiazepines exhibited IC50 values in the low nanomolar range as measured by the displacement of [H-3]PK 11195 binding. Compound 4i was found to be the most potent ligand for this receptor in the pyrrolobenzothiazepine subgroup with an IC50 practically identical to that determined for PK 11195. Structure-affinity relationships (SARs) have been developed to elucidate the topology of the PER binding site.

  DOI：

  10.1016/s0223-5234(97)83975-x