[EN] RNA-TARGETING LIGANDS, COMPOSITIONS THEREOF, AND METHODS OF MAKING AND USING THE SAME<br/>[FR] LIGANDS DE CIBLAGE D'ARN, LEURS COMPOSITIONS ET PROCÉDÉS DE FABRICATION ET D'UTILISATION ASSOCIÉS
申请人:UNIV NORTH CAROLINA CHAPEL HILL
公开号:WO2021026245A1
公开(公告)日:2021-02-11
The disclosure is directed to compounds that bind to a target RNA molecule, such as a TPP riboswitch, compositions comprising the compounds, and methods of making and using the same. The compounds contain two structurally different fragments that allow for binding with the target RNA at two different binding sites thereby producing a higher affinity 5 binding ligand compared to compounds that only bind to a single RNA binding site.
该披露涉及与目标RNA分子结合的化合物,例如TPP核糖开关,包括这些化合物的组合物,以及制备和使用这些化合物的方法。这些化合物包含两个结构不同的片段,可以在目标RNA的两个不同结合位点结合,从而产生比只在单个RNA结合位点结合的化合物具有更高亲和力的5结合配体。