N-[4-(1,4-benzodioxan-2-yl)thiazol-2-yl]benzamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并二恶烷
• 英文名称: N-[4-(1,4-benzodioxan-2-yl)thiazol-2-yl]benzamide
• 英文别名: N-[4-(2,3-dihydro-1,4-benzodioxin-2-yl)-1,3-thiazol-2-yl]benzamide；N-[4-(2,3-dihydro-1,4-benzodioxin-3-yl)-1,3-thiazol-2-yl]benzamide
• 化学式: C₁₈H₁₄N₂O₃S
• 分子量: 338.387
• InChiKey: DLIPUDWURCNQAZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  88.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-[4-(1,4-benzodioxan-2-yl)thiazol-2-yl]benzamide 在 lithium aluminium tetrahydride 作用下， 以 乙醚 、 苯 为溶剂， 反应 18.0h， 生成 N-benzyl-4-(1,4-benzodioxan-2-yl)-thiazol-2-amine
  参考文献：
  名称：

  Synthesis and biologic properties of new thiazolylbenzodioxane derivatives

  摘要：

  Reaction of 4-(1,4-benzodioxan-2-yl)thiazol-2-amine with acid chlorides afforded N-substituted amides which further were reduced into the corresponding amines. A new method was developed of preparation of 2-acetyl-1,4-benzodioxane, the initial compound in the synthesis of thiazolylbenzodioxane and numerous derivatives of this series. The adreno- and sympatholytic as well as antihypoxic effect of the obtained biheterocyclic 1,4-benzodioxane derivatives were investigated.

  DOI：

  10.1134/s1070428016020159
• 作为产物：
  描述：

  2,3-二氢苯并[1,4]二恶烷-2-甲腈 在 溴 、 碘 、 magnesium 、 calcium carbonate 、 sodium hydroxide 作用下， 以 吡啶 、 乙醚 、 乙醇 、 正己烷 、 水 、 苯 为溶剂， 反应 21.67h， 生成 N-[4-(1,4-benzodioxan-2-yl)thiazol-2-yl]benzamide
  参考文献：
  名称：

  Synthesis and biologic properties of new thiazolylbenzodioxane derivatives

  摘要：

  Reaction of 4-(1,4-benzodioxan-2-yl)thiazol-2-amine with acid chlorides afforded N-substituted amides which further were reduced into the corresponding amines. A new method was developed of preparation of 2-acetyl-1,4-benzodioxane, the initial compound in the synthesis of thiazolylbenzodioxane and numerous derivatives of this series. The adreno- and sympatholytic as well as antihypoxic effect of the obtained biheterocyclic 1,4-benzodioxane derivatives were investigated.

  DOI：

  10.1134/s1070428016020159

文献信息

• Synthesis and biologic properties of new thiazolylbenzodioxane derivatives
  作者：S. O. Vartanyan、A. S. Avakyan、A. B. Sargsyan、S. A. Arutyunyan、O. S. Noravyan、A. S. Tsatinyan

  DOI：10.1134/s1070428016020159

  日期：2016.2

  Reaction of 4-(1,4-benzodioxan-2-yl)thiazol-2-amine with acid chlorides afforded N-substituted amides which further were reduced into the corresponding amines. A new method was developed of preparation of 2-acetyl-1,4-benzodioxane, the initial compound in the synthesis of thiazolylbenzodioxane and numerous derivatives of this series. The adreno- and sympatholytic as well as antihypoxic effect of the obtained biheterocyclic 1,4-benzodioxane derivatives were investigated.