N,N-diisopropylaminoethyl-methylamine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N-diisopropylaminoethyl-methylamine
• 英文别名: 1-N',1-N'-di(propan-2-yl)propane-1,1-diamine
• 化学式: C₉H₂₂N₂
• 分子量: 158.287
• InChiKey: RHWKTXUQAMENNV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  二苯基乙酰氯 、 N,N-diisopropylaminoethyl-methylamine 在 盐酸 、 三乙胺 作用下， 以3.7 g (95%)的产率得到N-methyl-N-(2-diisopropylaminoethyl)-2,2-diphenyl-acetamide hydrochloride
  参考文献：
  名称：

  Compounds for the treatment of urinary incontinence

  摘要：

  该发明涉及具有以下式I的化合物 其中Ar是苯基或苄基，可以选择地用羟基或烷氧基取代；R1是氢、低烷基、低烷氧基、羟基；R2是氢、低烷基；R3是NR4R5，其中R4和R5可以相同也可以不同，为低烷基，或者当R4和R5一起时，与氮原子形成一个环，所述环可以选择地用低烷基取代；n为0或1；m为2或3以及它们与生理上可接受的酸盐，当化合物可以为光学异构体时，为治疗尿道膀胱疾病的消光体混合物和各个异构体。

  公开号：

  US05236956A1

文献信息

• METHOD FOR CONTINUOUSLY PRODUCING ALKYLAMINO(METH)ACRYLAMIDES
  申请人：Schmitt Bardo

  公开号：US20110313195A1

  公开（公告）日：2011-12-22

  The invention relates to a process for continuously preparing N-alkyl(meth)acrylamides by reacting alkyl (meth)acrylates with high-boiling amines. A catalyst activation and specific workup technique achieve product qualities which have not been achieved to date. In addition, very high space-time yields and overall yields can be achieved.

  本发明涉及一种通过将烷基（甲基）丙烯酸酯与高沸点胺反应来连续制备N-烷基（甲基）丙烯酰胺的工艺。通过催化剂激活和特定的后处理技术，可以实现迄今为止未曾达到的产品质量。此外，还可以实现非常高的空间时间收率和总收率。
• PREPARATION OF N,N-(DI)ALKYLAMINOALKYL(METH)ACRYLAMIDE OR N,N-(DI)ALKYLAMINOALKYL (METH)ACRYLATE AND THE QUATERNARY AMMONIUM SALTS THEREOF AS FLOCCULATING AIDS AND GELLING AGENTS
  申请人：Evonik Roehm GmbH

  公开号：US20170369424A1

  公开（公告）日：2017-12-28

  N,N-(di)alkylaminoalkyl(meth)acrylamide or N,N-(di)alkylaminoalkyl (meth)acrylate and/or a quaternary ammonium salt thereof are prepared with a low content of a compound of formula (IV) wherein R 5 in each case is a linear, branched or cyclic alkyl radical, an aryl radical which may also be substituted by one or more alkyl groups, the linear, cyclic or branched alkyl radical may have a length of 1-12 carbon atoms and is, for example, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl, hexyl, heptyl, octyl, isooctyl, nonyl, decyl, undecyl, dodecyl.

  制备低含量的化合物公式（IV）其中R5在每种情况下都是线性，支链或环烷基，芳基，也可以被一个或多个烷基取代，线性，环状或支链烷基长度可以为1-12个碳原子，例如甲基，乙基，丙基，异丙基，丁基，异丁基，叔丁基，戊基，己基，庚基，异辛基，壬基，癸基。制备N，N-（二）烷基氨基烷基（甲基）丙烯酰胺或N，N-（二）烷基氨基烷基（甲基）丙烯酸酯和/或其季铵盐。
• 1H-pyrazole-1-alkanamides and preparation useful as antiarrhythmic agents
  申请人：STERLING DRUG INC.

  公开号：EP0299407A1

  公开（公告）日：1989-01-18

  N-[(disubstituted amino)alkyl]-3,4 (or 4,5)-diaryl-­1H-pyrazole-1-acetamides and pyrazole-1-propanamides, useful for treating cardiac arrhythmias in mammals, are prepared by reacting a lower-alkyl ester or pyrazole-1-acetic or propanoic acid with an appropriate diamine or by reacting a lower-alkyl ester of a pyrazole-1-acetic or propanoic acid with an ω-­aminoalkanol, followed by activation of the alcohol and displacement of an appropriate amine.

  N-[(二取代氨基)烷基]-3,4(或 4,5)-二芳基-1H-吡唑-1-乙酰胺和吡唑-1-丙酰胺，可用于治疗哺乳动物的心律失常、其制备方法是将吡唑-1-乙酸或丙酸的低级烷基酯与适当的二胺反应，或将吡唑-1-乙酸或丙酸的低级烷基酯与ω-氨基醇反应，然后使醇活化并置换适当的胺。
• Azole-1-alkanamides as antiarrhythmic agents and preparation thereof
  申请人：STERLING DRUG INC.

  公开号：EP0388654A2

  公开（公告）日：1990-09-26

  N-[(alkylamino)alkyl]3,4 (or 4,5)-diaryl-1H-­pyrazole-1-(branched)alkanamides and pyrazole-1-alkanamines useful for treating cardiac arrhythmias in mammals, are prepared by reacting a lower-alkyl ester of pyrazole-1-­acetic acid with an appropriate diamine followed by reduction or by reacting the anion of a lower-alkyl ester of a pyrazole-1-acetic acid with an alkylating agent followed by displacement of the ester by an appropriate amine.

  用于治疗哺乳动物心律失常的 N-[(烷基氨基)烷基]3,4(或 4,5)-二芳基-1H-吡唑-1-(支链)烷酰胺和吡唑-1-烷胺、吡唑-1-乙酸的低级烷基酯与适当的二胺反应，然后还原，或吡唑-1-乙酸的低级烷基酯的阴离子与烷化剂反应，然后酯被适当的胺置换，即可制备。
• Preparation of N,N-(di)alkylaminoalkyl(meth)acrylamide or N,N-(di)alkylaminoalkyl (meth)acrylate and the quaternary ammonium salts thereof as flocculating aids and gelling agents
  申请人：Evonik Roehm GmbH

  公开号：US10343980B2

  公开（公告）日：2019-07-09

  N,N-(di)alkylaminoalkyl(meth)acrylamide or N,N-(di)alkylaminoalkyl (meth)acrylate and/or a quaternary ammonium salt thereof are prepared with a low content of a compound of formula (IV) wherein R5 in each case is a linear, branched or cyclic alkyl radical, an aryl radical which may also be substituted by one or more alkyl groups, the linear, cyclic or branched alkyl radical may have a length of 1-12 carbon atoms and is, for example, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl, hexyl, heptyl, octyl, isooctyl, nonyl, decyl, undecyl, dodecyl.

  用低含量的式 (IV) 化合物制备 N,N-(二)烷基氨基烷基（甲基）丙烯酰胺或 N,N-(二)烷基氨基烷基（甲基）丙烯酸酯和/或其季铵盐 其中 R5 在每种情况下均为直链、支链或环状烷基，也可以是被一个或多个烷基取代的芳基，直链、环状或支链烷基的长度为 1-12 个碳原子，例如为甲基、乙基、丙基、异丙基、丁基、异丁基、叔丁基、戊基、己基、庚基、辛基、异辛基、壬基、癸基、十一烷基、十二烷基。