2-((4-Diphenylphosphoryl-3-thiocyanato)butyl)-isoindoline-1,3-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 2-((4-Diphenylphosphoryl-3-thiocyanato)butyl)-isoindoline-1,3-dione
• 英文别名: [4-(1,3-Dioxoisoindol-2-yl)-1-diphenylphosphorylbutan-2-yl] thiocyanate；[4-(1,3-dioxoisoindol-2-yl)-1-diphenylphosphorylbutan-2-yl] thiocyanate
• 化学式: C₂₅H₂₁N₂O₃PS
• 分子量: 460.493
• InChiKey: QCLDMPINQHHKAH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  32
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  104
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  N-(4-烯丁基)邻苯二甲酰亚胺 、 异硫氢酸三甲基硅酯 、 Diphenylphosphine oxide 在 2,2'-联吡啶 、 manganese(III) triacetate dihydrate 、 copper(ll) bromide 作用下， 反应 3.0h， 生成 2-((4-Diphenylphosphoryl-3-thiocyanato)butyl)-isoindoline-1,3-dione 、
  参考文献：
  名称：

  Phosphinoyl Radical-Initiated 1,2-Bifunctional Thiocyanodiphenylphosphinoylation of Alkenes

  摘要：

  1,2-Bifuctional thiocyanodiphenylphosphinoylation of alkenes is established through the phosphinoyl radical addition followed by Cu-catalyzed thiocyanation. This one-pot reaction is applicable to a range of aromatic, aliphatic, and cyclic alkenes to afford thiocyanodiphenylphosphinoylated compounds in satisfactory yields.

  DOI：

  10.1021/acs.joc.7b02929

文献信息

• Phosphinoyl Radical-Initiated 1,2-Bifunctional Thiocyanodiphenylphosphinoylation of Alkenes
  作者：Ze-Kun Tao、Cheng-Kun Li、Pei-Zhi Zhang、Adedamola Shoberu、Jian-Ping Zou、Wei Zhang

  DOI：10.1021/acs.joc.7b02929

  日期：2018.2.16

  1,2-Bifuctional thiocyanodiphenylphosphinoylation of alkenes is established through the phosphinoyl radical addition followed by Cu-catalyzed thiocyanation. This one-pot reaction is applicable to a range of aromatic, aliphatic, and cyclic alkenes to afford thiocyanodiphenylphosphinoylated compounds in satisfactory yields.