picolinic acid N¹-(2-benzothienylmethylene)amidrazone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: picolinic acid N¹-(2-benzothienylmethylene)amidrazone
• 英文别名: N'-(1-benzothiophen-2-ylmethylideneamino)pyridine-2-carboximidamide
• 化学式: C₁₅H₁₂N₄S
• 分子量: 280.353
• InChiKey: ZDZHJPSEOZTQMM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.04
• 重原子数：
  20.0
• 可旋转键数：
  3.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  63.63
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  1-苯并噻酚-2-羧醛 、 2-吡啶氨基腙 以 乙醇 为溶剂， 以83%的产率得到picolinic acid N¹-(2-benzothienylmethylene)amidrazone
  参考文献：
  名称：

  NewN1-Hetarylmethylene-Substituted Amidrazones with Potential Antimycobacterial Activity

  摘要：

  N-1-Hetarylmethylene (e.g. pyridyl, 2-benzoxazolyl, 2-benzofuryl) substituted picolinic acid amidrazones and pyrazine-2-carboxamidrazones were investigated. The compounds were accessible by reaction of the unsubstituted amidrazones with aldehydes. Pyrazine-2-carbox-N-1-(2-benzoxazolymethylene)amidrazones were obtained by a new multistep reaction. The investigated amidrazones were tested for their antibacterial activity against four strains of mycobacteria (M. tuberculosis, M. avium, M. intracellulare, M. lufu) and were shown to have rather low activity.

  DOI：

  10.1002/(sici)1521-4184(199912)332:12<427::aid-ardp427>3.0.co;2-h

文献信息

• NewN1-Hetarylmethylene-Substituted Amidrazones with Potential Antimycobacterial Activity
  作者：Donald Ranft、Torsten Seyfarth、Klaus-Jürgen Schaper、Gudrun Lehwark-Yvetot、Clemens Bruhn、Axel Büge

  DOI：10.1002/(sici)1521-4184(199912)332:12<427::aid-ardp427>3.0.co;2-h

  日期：1999.12

  N-1-Hetarylmethylene (e.g. pyridyl, 2-benzoxazolyl, 2-benzofuryl) substituted picolinic acid amidrazones and pyrazine-2-carboxamidrazones were investigated. The compounds were accessible by reaction of the unsubstituted amidrazones with aldehydes. Pyrazine-2-carbox-N-1-(2-benzoxazolymethylene)amidrazones were obtained by a new multistep reaction. The investigated amidrazones were tested for their antibacterial activity against four strains of mycobacteria (M. tuberculosis, M. avium, M. intracellulare, M. lufu) and were shown to have rather low activity.