2-methyl-2-(2-methylprop-1-en-1-yl)-3,4-dihydro-2H-benzo[g]chromen-5,10-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并吡喃类
• 英文名称: 2-methyl-2-(2-methylprop-1-en-1-yl)-3,4-dihydro-2H-benzo[g]chromen-5,10-dione
• 英文别名: 2-Methyl-2-(2-methylprop-1-enyl)-3,4-dihydrobenzo[g]chromene-5,10-dione
• 化学式: C₁₈H₁₈O₃
• 分子量: 282.339
• InChiKey: CBGYJKUQAAHCTH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,4-二甲基-1,3-戊二烯 、 聚合甲醛 、 2-羟基-1,4-萘醌 以 1,4-二氧六环 为溶剂， 反应 6.0h， 以54%的产率得到2-methyl-2-(2-methylprop-1-en-1-yl)-3,4-dihydro-2H-benzo[g]chromen-5,10-dione
  参考文献：
  名称：

  Hetero Diels–Alder trapping of 3-methylene-1,2,4-[3H]naphthalenetrione: an efficient protocol for the synthesis of α- and β-lapachone derivatives

  摘要：

  3-Methylene-1,2,4-[3H]naphthalenetrione, generated by Knoevenagel condensation of 2-hydroxy-1,4-naphthoquinone with formaldehyde, undergoes facile hetero Diels-Alder reaction with various dienophiles affording derivatives of alpha- and beta -lapachone. (C) 2001 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(01)00741-9

文献信息

• Method for controlling NAD(P)/NAD(P)H ratio by oxidoreductase
  申请人：Md Bioalpha Co., Ltd.

  公开号：EP2426212A1

  公开（公告）日：2012-03-07

  The present invention provides a method capable of effectively treating various diseases associated with energy excess, such as obesity, diabetes, metabolic syndromes, degenerative diseases and mitochrondrial dysfunction-related diseases, via elevation of an NAD(P)+ZNAD(P)H ratio by increasing an NAD(P)+ concentration in vivo or in vitro through use of NAD(P)H as a substrate or coenzyme by oxidoreductase such as NAD(P)H:quinine oxidoreductase (NQO1), a method of screening a drug for the same and a therapeutic drug.

  本发明提供了一种能够有效治疗与能量过剩有关的各种疾病的方法，如肥胖症、糖尿病、代谢综合征、退行性疾病和线粒体功能障碍相关疾病，其方法是通过氧化还原酶如NAD(P)H：Quinine oxidoreductase (NQO1)）来提高体内或体外的 NAD(P) + 浓度的方法、筛选相同药物的方法以及治疗药物。
• METHOD FOR CONTROLLING NAD(P)/NAD(P)H RATIO BY OXIDOREDUCTASE
  申请人：Park Myung-Gyu

  公开号：US20090215145A1

  公开（公告）日：2009-08-27

  Provided is a method capable of effectively treating various diseases associated with energy excess, such as obesity, diabetes, metabolic syndromes, degenerative diseases and mitochondrial dysfunction-related diseases, via elevation of an NAD(P) + /NAD(P)H ratio by increasing an NAD(P) + concentration in vivo or in vitro through use of NAD(P)H as a substrate or coenzyme by oxidoreductase such as NAD(P)H:quinone oxidoreductase (NQO1), a method of screening a drug for the same and a therapeutic drug.
• Hetero Diels–Alder trapping of 3-methylene-1,2,4-[3H]naphthalenetrione: an efficient protocol for the synthesis of α- and β-lapachone derivatives
  作者：Vijay Nair、P.M Treesa

  DOI：10.1016/s0040-4039(01)00741-9

  日期：2001.7

  3-Methylene-1,2,4-[3H]naphthalenetrione, generated by Knoevenagel condensation of 2-hydroxy-1,4-naphthoquinone with formaldehyde, undergoes facile hetero Diels-Alder reaction with various dienophiles affording derivatives of alpha- and beta -lapachone. (C) 2001 Published by Elsevier Science Ltd.