(3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)acetic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: (3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)acetic acid
• 英文别名: 2-(2,5,7,8-Tetramethyl-3,4-dihydrochromen-2-yl)acetic acid
• 化学式: C₁₅H₂₀O₃
• 分子量: 248.322
• InChiKey: SPNBWKBYLZDPIP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,3,5-三甲基苯酚 在 palladium on activated charcoal 氢氧化钾 、 氢气 、 四氯化钛 、 potassium carbonate 作用下， 以 乙醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 生成 (3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)acetic acid
  参考文献：
  名称：

  Solid-phase synthesis: a linker for side-chain anchoring of arginine

  摘要：

  A new linker based on a chroman system is described for the side-chain anchoring of Arg and other guanidine-containing molecules. The system is compatible with the Fmoc/tBu solid-phase strategy, because the release of the final product is achieved by treatment with TFA in the presence of scavengers. (C) 2003 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(03)01203-6

文献信息

• Sulphonyl compounds for use as linkers in solid phase and combinatorial synthesis
  申请人：Fujisawa Pharmaceutical Co. Ltd.

  公开号：US20010012901A1

  公开（公告）日：2001-08-09

  The present invention relates to a linker shown by the following formula (I): X—S0 2 —R 1 —(A) m —R 2 (I) wherein R 1 is a group of the formula (A): 1 [wherein R 3 , R 4 and R 5 are the same or different hydrogen, etc], etc, R 2 is a group which can form a chemical bond to a resin which may be protected by a conventional protective group, A is lower alkylene, etc, X is a leaving group, and m is an integer of 0 or 1, with proviso that A is (C 2 -C 6 )alkylene, and m is an integer of 1, when R 1 is a group of the formula (A).

  本发明涉及一种由以下式（I）所示的连接剂：X—S02—R1—（A）m—R2（I）其中，R1是式（A）的基团：1 [其中R3，R4和R5相同或不同，为氢等等]，等等，R2是可以形成与可能由传统保护基保护的树脂的化学键的基团，A是低级烷基等，X是离去基，m是0或1的整数，条件是当R1是式（A）的基团时，A是（C2-C6）烷基，m是1的整数。
• US6225480B1
  申请人：——

  公开号：US6225480B1

  公开（公告）日：2001-05-01
• Solid-phase synthesis: a linker for side-chain anchoring of arginine
  作者：Oscar Garcı́a、Ernesto Nicolás、Fernando Albericio

  DOI：10.1016/s0040-4039(03)01203-6

  日期：2003.7.7

  A new linker based on a chroman system is described for the side-chain anchoring of Arg and other guanidine-containing molecules. The system is compatible with the Fmoc/tBu solid-phase strategy, because the release of the final product is achieved by treatment with TFA in the presence of scavengers. (C) 2003 Published by Elsevier Science Ltd.