N,N-diethyl-2-selenonaphthylamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N,N-diethyl-2-selenonaphthylamide
• 英文别名: N,N-diethylnaphthalene-2-carboselenoamide
• 化学式: C₁₅H₁₇NSe
• 分子量: 290.267
• InChiKey: SKWWOUGPMWONOB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.83
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N,N-二乙基-2-萘甲酰胺 在 草酰氯 、 LiAlHSeH 作用下， 以 乙醚 、 四氢呋喃 为溶剂， 反应 7.0h， 以54%的产率得到N,N-diethyl-2-selenonaphthylamide
  参考文献：
  名称：

  Tertiary selenoamide compounds are useful superoxide radical scavengers in vitro

  摘要：

  We investigated the scavenging effects of tertiary selenoamide compounds for super oxide radicals using a highly sensitive and quantitative chemiluminescence method. At 333 nM, tertiary selenoamide compounds scavenged 25.8-81.6% of O-2(-.).N-(Phenylselenocarbonyl) piperidine was the most effective scavenger of superoxide radicals. While N,N-diethyl-2-selenonaphthylamide and N,N-diethyl-4-chloroselenobenzamide was a moderately effective scavenger of superoxide radicals. The IC50 of N-(phenylselenocarbonyl) piperidine and N,N-diethyl-2-selenonaphthylamide were determined to be 110 and 182 nM, respectively. The results suggest that tertiary selenoamide compounds are useful scavengers of superoxide radicals. (C) 2004 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ejps.2004.04.011

文献信息

• Tertiary selenoamide compounds are useful superoxide radical scavengers in vitro
  作者：Hitoe Takahashi、Atsuyoshi Nishina、Hirokazu Kimura、Kenji Motoki、Mamoru Koketsu、Hideharu Ishihara

  DOI：10.1016/j.ejps.2004.04.011

  日期：2004.11

  We investigated the scavenging effects of tertiary selenoamide compounds for super oxide radicals using a highly sensitive and quantitative chemiluminescence method. At 333 nM, tertiary selenoamide compounds scavenged 25.8-81.6% of O-2(-.).N-(Phenylselenocarbonyl) piperidine was the most effective scavenger of superoxide radicals. While N,N-diethyl-2-selenonaphthylamide and N,N-diethyl-4-chloroselenobenzamide was a moderately effective scavenger of superoxide radicals. The IC50 of N-(phenylselenocarbonyl) piperidine and N,N-diethyl-2-selenonaphthylamide were determined to be 110 and 182 nM, respectively. The results suggest that tertiary selenoamide compounds are useful scavengers of superoxide radicals. (C) 2004 Elsevier B.V. All rights reserved.