5-(dimethylamino)-N-(tris{(2-(tert-butoxycarbonyl) ethoxy) methyl}methyl]naphthalene-1-sulfonamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 5-(dimethylamino)-N-(tris{(2-(tert-butoxycarbonyl) ethoxy) methyl}methyl]naphthalene-1-sulfonamide
• 英文别名: Tert-butyl 3-[2-[[5-(dimethylamino)naphthalen-1-yl]sulfonylamino]-3-[3-[(2-methylpropan-2-yl)oxy]-3-oxopropoxy]-2-[[3-[(2-methylpropan-2-yl)oxy]-3-oxopropoxy]methyl]propoxy]propanoate；tert-butyl 3-[2-[[5-(dimethylamino)naphthalen-1-yl]sulfonylamino]-3-[3-[(2-methylpropan-2-yl)oxy]-3-oxopropoxy]-2-[[3-[(2-methylpropan-2-yl)oxy]-3-oxopropoxy]methyl]propoxy]propanoate
• 化学式: C₃₇H₅₈N₂O₁₁S
• 分子量: 738.94
• InChiKey: MFGTXUPDUMFLGA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  51
• 可旋转键数：
  25
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  164
• 氢给体数：
  1
• 氢受体数：
  13

反应信息

• 作为反应物：
  描述：

  5-(dimethylamino)-N-(tris{(2-(tert-butoxycarbonyl) ethoxy) methyl}methyl]naphthalene-1-sulfonamide 在 甲酸 作用下， 反应 24.0h， 以98%的产率得到5-(dimethylamino)-N-{tris[(2-carboxyethoxy)methyl]methyl}naphthalene-1-sulfonamide
  参考文献：
  名称：

  Spatially Resolved Derivatization of Solid-Phase-Synthesis Beads with Fluorescent Dendrimers: Creation of Localized Microdomains

  摘要：

  Second and third generation Newkome-type trifurcated dendrimers, containing either a coumarin or dansyl fluorescent probe at the dendrimer core, have been synthesized and attached to ArgoGel (R) solid-phase-synthesis beads. Subsequent reaction with rhodamine dye shows that the dye can penetrate throughout the beads to acylate the remaining sites. Thus, it is possible to achieve a spatially resolved microdomain for library formation at the core of the dendrimer, primarily on the bead's periphery, and a second microdomain suitable for derivatization by other reagents such as encoding tags and fluorescent sensors.

  DOI：

  10.1002/1522-2675(200210)85:10<3532::aid-hlca3532>3.0.co;2-f
• 作为产物：
  描述：

  丹酰氯 、 三[[2-(叔-丁氧羰基)乙氧基]甲基]甲胺 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 反应 36.0h， 以81%的产率得到5-(dimethylamino)-N-(tris{(2-(tert-butoxycarbonyl) ethoxy) methyl}methyl]naphthalene-1-sulfonamide
  参考文献：
  名称：

  Spatially Resolved Derivatization of Solid-Phase-Synthesis Beads with Fluorescent Dendrimers: Creation of Localized Microdomains

  摘要：

  Second and third generation Newkome-type trifurcated dendrimers, containing either a coumarin or dansyl fluorescent probe at the dendrimer core, have been synthesized and attached to ArgoGel (R) solid-phase-synthesis beads. Subsequent reaction with rhodamine dye shows that the dye can penetrate throughout the beads to acylate the remaining sites. Thus, it is possible to achieve a spatially resolved microdomain for library formation at the core of the dendrimer, primarily on the bead's periphery, and a second microdomain suitable for derivatization by other reagents such as encoding tags and fluorescent sensors.

  DOI：

  10.1002/1522-2675(200210)85:10<3532::aid-hlca3532>3.0.co;2-f

文献信息

• Spatially Resolved Derivatization of Solid-Phase-Synthesis Beads with Fluorescent Dendrimers: Creation of Localized Microdomains
  作者：Claudia M. Cardona、Stephan H. Jannach、Hao Huang、Yukiko Itojima、Roger M. Leblanc、Robert E. Gawley、Gary A. Baker、Eric B. Brauns

  DOI：10.1002/1522-2675(200210)85:10<3532::aid-hlca3532>3.0.co;2-f

  日期：2002.10

  Second and third generation Newkome-type trifurcated dendrimers, containing either a coumarin or dansyl fluorescent probe at the dendrimer core, have been synthesized and attached to ArgoGel (R) solid-phase-synthesis beads. Subsequent reaction with rhodamine dye shows that the dye can penetrate throughout the beads to acylate the remaining sites. Thus, it is possible to achieve a spatially resolved microdomain for library formation at the core of the dendrimer, primarily on the bead's periphery, and a second microdomain suitable for derivatization by other reagents such as encoding tags and fluorescent sensors.