(1RS,5SR,6SR)-6-ethoxy-2,3,5,6-tetrahydro-9-methoxy-3,8,11-trimethyl-1,5-imino-3-benzazocine-4,7,10(1H)-trione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: (1RS,5SR,6SR)-6-ethoxy-2,3,5,6-tetrahydro-9-methoxy-3,8,11-trimethyl-1,5-imino-3-benzazocine-4,7,10(1H)-trione
• 英文别名: (1R,8S,9S)-8-ethoxy-4-methoxy-5,11,13-trimethyl-11,13-diazatricyclo[7.3.1.02,7]trideca-2(7),4-diene-3,6,10-trione
• 化学式: C₁₇H₂₂N₂O₅
• 分子量: 334.372
• InChiKey: GLYVQPSQRWEFKD-HCYDYPBKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  76.2
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  乙醇 、 1,2,3,4,5,6,7,10-octahydro-9-methoxy-3,8,11-trimethyl-1,5-imino-3-benzazocine-4,7,10-trione 在 selenium(IV) oxide 作用下， 以 1,4-二氧六环 为溶剂， 反应 32.0h， 以86%的产率得到(1RS,5SR,6SR)-6-ethoxy-2,3,5,6-tetrahydro-9-methoxy-3,8,11-trimethyl-1,5-imino-3-benzazocine-4,7,10(1H)-trione
  参考文献：
  名称：

  Selenium Oxide Oxidation of Hexahydro-1,5-imino-3-benzazocine-7,10-dione in Aliphatic Alcohol for Conversion of Renieramycin Marine Natural Products

  摘要：

  A selenium oxide oxidation of hexahydro-1,5-imino-3-benzazocine-7,10-dione derivatives in several aliphatic alcohols to generate C-6 ether derivatives stereoselectively is described. This procedure shows promise for the construction of several renieramycins, such as renieramycins B, D, and V. The results of cytotoxicity studies are also presented.

  DOI：

  10.3987/com-12-s(n)12

文献信息

• Selenium Oxide Oxidation of Hexahydro-1,5-imino-3-benzazocine-7,10-dione in Aliphatic Alcohol for Conversion of Renieramycin Marine Natural Products
  作者：Naoki Saito、Naomi Daikuhara、Junya Yamada、Mayuko Mori

  DOI：10.3987/com-12-s(n)12

  日期：——

  A selenium oxide oxidation of hexahydro-1,5-imino-3-benzazocine-7,10-dione derivatives in several aliphatic alcohols to generate C-6 ether derivatives stereoselectively is described. This procedure shows promise for the construction of several renieramycins, such as renieramycins B, D, and V. The results of cytotoxicity studies are also presented.