1,5-bis[(5-methylisoxazol-3-ylamino)(thiophen-2-yl)methyl]naphthalene-2,6-diol

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1,5-bis[(5-methylisoxazol-3-ylamino)(thiophen-2-yl)methyl]naphthalene-2,6-diol
• 英文别名: 1,5-bis[(S)-[(5-methyl-1,2-oxazol-3-yl)amino]-thiophen-2-ylmethyl]naphthalene-2,6-diol
• 化学式: C₂₈H₂₄N₄O₄S₂
• 分子量: 544.655
• InChiKey: DUHMDWUYOLUGBX-VSGBNLITSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  38
• 可旋转键数：
  8
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  173
• 氢给体数：
  4
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  2-噻吩甲醛 、 3-氨基-5-甲基异恶唑 、 2,6-萘二酚 反应 5.0h， 生成 1,5-bis[(5-methylisoxazol-3-ylamino)(thiophen-2-yl)methyl]naphthalene-2,6-diol 、 1,5-bis[(5-methylisoxazol-3-ylamino)(thiophen-2-yl)methyl]naphthalene-2,6-diol
  参考文献：
  名称：

  An efficient, expeditious, and diastereoselective one-pot pseudo-five-component reaction for the synthesis of new bis-Betti bases under catalyst-free conditions

  摘要：

  A novel, diastereoselective, one-pot synthesis of new bis-Betti bases via condensation of dihydroxynaphthalene, two equivalents of aryl aldehydes, and two equivalents of 3-amino-5-methylisoxazole is reported. Conversion into the adducts was almost quantitative without the use of solvent or catalyst. The reaction conditions are very simple and enable easy isolation of the product. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.04.037

文献信息

• An efficient, expeditious, and diastereoselective one-pot pseudo-five-component reaction for the synthesis of new bis-Betti bases under catalyst-free conditions
  作者：Mehdi Shafiee、Ahmad R. Khosropour、Iraj Mohammadpoor-Baltork、Majid Moghadam、Shahram Tangestaninejad、Valiollah Mirkhani

  DOI：10.1016/j.tetlet.2012.04.037

  日期：2012.6

  A novel, diastereoselective, one-pot synthesis of new bis-Betti bases via condensation of dihydroxynaphthalene, two equivalents of aryl aldehydes, and two equivalents of 3-amino-5-methylisoxazole is reported. Conversion into the adducts was almost quantitative without the use of solvent or catalyst. The reaction conditions are very simple and enable easy isolation of the product. (C) 2012 Elsevier Ltd. All rights reserved.