N,N-Diethyl-2-trimethylsilyl-1-naphthamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N,N-Diethyl-2-trimethylsilyl-1-naphthamide
• 英文别名: N,N-Diethyl-2-(trimethylsilyl)-1-naphthalenecarboxamide；N,N-diethyl-2-trimethylsilylnaphthalene-1-carboxamide
• 化学式: C₁₈H₂₅NOSi
• 分子量: 299.488
• InChiKey: DWZRAJTXKOZPHZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.87
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N,N-二乙基-1-萘羧酰胺 以71%的产率得到N,N-Diethyl-2-trimethylsilyl-1-naphthamide
  参考文献：
  名称：

  Fungicides for the control of take-all disease of plants

  摘要：

  由土壤中的真菌Gaeumannonyces graminis (Gg)引起的植物病害可通过施用具有以下一般化学式的杀菌剂来控制：##STR1##

  公开号：

  US05994270A1

文献信息

• Atroposelectivity in the reactions of ortholithiated aromatic tertiary amides with aldehydes
  作者：Peter Bowles、Jonathan Clayden、Madeleine Helliwell、Catherine McCarthy、Matthew Tomkinson、Neil Westlund

  DOI：10.1039/a701671i

  日期：——

  The products of the addition of ortholithiated N,N-dialkylnaphthamides to aldehydes are pairs of stable, diastereoisomeric atropisomers, formed with selectivities of up to 90∶10 in favour of the syn-atropisomer.

  将N,N-二烷基萘酰胺与醛加成得到的产品是一对稳定的、在轴向位置具有非对映异构性的对映异构体，其选择性高达90∶10，倾向于生成syn-对映异构体。
• Diastereoisomeric atropisomers from the addition of lithiated N,N-dialkyl-l-naphthamides to aldehydes
  作者：Peter Bowles、Jonathan Clayden、Matthew Tomkinson

  DOI：10.1016/0040-4039(95)01945-e

  日期：1995.12

  2-Substituted N,N-diethyl or N,N-diisopropyl 1-naphthamides exist as stable atropisomers. When the 2-substituent is a 1-hydroxyalkyl group, the atropisomers are separable diastereoisomers. Synthesis of these compounds by the addition of aldehydes to ortholithiated N,N-dialkyl 1-naphthamides proceeds with moderate to good diastereoselectivity in favour of the aR*S* (syn) diastereoisomer.
• Fungicides for the control of take-all disease of plants
  申请人：Monsanto Company

  公开号：US05994270A1

  公开（公告）日：1999-11-30

  Plant disease caused by soil-borne fungus Gaeumannonyces graminis (Gg) is controlled by applying to the seed or the soil a fungicide which has the following general formula: ##STR1##

  由土壤中的真菌Gaeumannonyces graminis (Gg)引起的植物病害可通过施用具有以下一般化学式的杀菌剂来控制：##STR1##