4,6-diallyl-4,6-diaza-5-thia-1,8-nonadiene

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4,6-diallyl-4,6-diaza-5-thia-1,8-nonadiene
• 英文别名: thiobisdiallylamine；N-[bis(prop-2-enyl)amino]sulfanyl-N-prop-2-enylprop-2-en-1-amine
• 化学式: C₁₂H₂₀N₂S
• 分子量: 224.37
• InChiKey: QCBMNUDJGSBGAE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  15
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  31.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  copper(II) choride dihydrate 、 4,6-diallyl-4,6-diaza-5-thia-1,8-nonadiene 以 乙醇 为溶剂， 以41%的产率得到N,N-diallylammonium trichlorodicuprate(I)
  参考文献：
  名称：

  Synthesis of disubstituted ammonium trichlorodicuprate(I) from the reaction of CuCl2 · 2H2O with N,N′-thiobisamines

  摘要：

  DOI：

  10.1016/s0277-5387(00)84414-9

文献信息

• Tris(dialkylamino)sulfonium bifluoride catalysts
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0121439A1

  公开（公告）日：1984-10-10

  Tris(dialkylamino)sulfonium bifluoride salts are obtained by hydrolysis, methanolysis, or pyrolysis of corresponding tris(dialkylamino)sulfonium difluorotrimethylsilicates, reaction of dialkylaminotrialkylsilanes with sulphur tetrafluoride, or reaction of bis(dialkylamino)sulfur difluorides with dialkylamines. These bifluoride salts, which have the general formula (R1R2N) (R1R4N) (RSR6N) S⊕HF2⊖, are useful polymerization catalysts.

  通过相应的三(二烷基氨基)锍二氟三甲基硅酸盐的水解、甲醇分解或热解，二烷基氨基三烷基硅烷与四氟化硫的反应，或双(二烷基氨基)二氟化硫与二烷基胺的反应，可获得三(二烷基氨基)锍双氟盐。这些具有通式 (R1R2N) (R1R4N) (RSR6N) S⊕HF2⊖ 的双氟盐是有用的聚合催化剂。
• 5-Deoxy-5-fluorokanamycin B derivatives and processes for the production thereof
  申请人：ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI

  公开号：EP0259014A2

  公开（公告）日：1988-03-09

  As new compounds are now provided 5-deoxy-5-fluorokanamycin B, 5,3'-dideoxy-5-fluorokanamycin B, 5,4'- dideoxy-5-fluorokanamycin B and 5,3',4'-trideoxy-5-fluorokanamycin B as well as 1-N-(3-amino-2-hydrox- ypropionyl)-or 1-N-(4-amino-2-hydroxybutyryl)-derivatives thereof which are all useful as antibacterial agents and exhibit improved antibacterial activities. These new compounds may be produced by synthetic processes starting from an appropriately N,O-protected 5-epi-kanamycin B, 3'-deoxy-5-epi-kanamycin B, 4'-deoxy-5-epi-kanamycin B or 3',4'-dideoxy-5-epi-kanamycin B derivative which is now prepared by a combination of reaction steps.

  现在提供的新化合物有 5-脱氧-5-氟卡那霉素 B、5,3'-二脱氧-5-氟卡那霉素 B、5,4'-二脱氧-5-氟卡那霉素 B 和 5,3'、4'-三脱氧-5-氟卡那霉素 B 及其 1-N-（3-氨基-2-羟基丙酰基）-或 1-N-（4-氨基-2-羟基丁酰基）-衍生物，它们都是有用的抗菌剂，并显示出更好的抗菌活性。这些新化合物可通过合成工艺制得，其起始原料为适当的 N，O 保护的 5-表卡那霉素 B、3'-脱氧-5-表卡那霉素 B、4'-脱氧-5-表卡那霉素 B 或 3',4'-双脱氧-5-表卡那霉素 B 衍生物，这些衍生物现在是通过反应步骤的组合制备的。
• 1-N-(4-Amino-3-fluoro-2-hydroxybutyryl)-kanamycins
  申请人：ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI

  公开号：EP0285526A2

  公开（公告）日：1988-10-05

  As new compound are now provided ten compounds, namely 1-N-(2R,3R)-4-amino-3-fluoro-2-hydroxybutyryl}-kanamycin A; 1-N-(2R,3R)-4-amino-3-fluoro-2-hydroxybuty- ryl}-2',3'-dideoxykanamycin A; 1-N-(2R,3R)-4-amino-fluoro-2-hydorxybutyryl}-2',3'-dideoxy-2'-fluorokanamycin A; 1-N-(2R,3R)-4-amino-3-fluoro-2-hydroxybutyryl}-5-deoxy-5-fluorokanamycin A; 1-N-((2R,3R)-4-amino-fluoro-2-hydrox- ybutyryl}-kanamycin B; 1-N-(2R,3R)-4-amino-3-fluoro-2-hy- droxybutyryl}-3'-deoxykanamycin B; 1-N-((2R,3R)-4-amino-3-fluoro-2-hydroxybutyryl}-3',4'-dideoxykanamycin B; 1-N-(2R,3R)-4-amino-3-fluoro-2-hydroxybutyryl}-5-deoxy-5-fluorokanamycin B; 1-N-(2R,3R)-4-amino-3-fluoro-2-hydrox- ybutyryl}-5,3'-dideoxy-5-fluorokanamycin B; and 1-N(2R,3R)-4-amino-3-fluoro-2-hydroxybutyryl}-5,3',4'-tride- oxy-5-fluorokanamycin B, which are all useful as antibacterial agent in the therapeutic treatment of bacterial infections.

  现在提供了十种新化合物，即 1-N-(2R,3R)-4-氨基-3-氟-2-羟基丁酰基}-卡那霉素 A；1-N-(2R,3R)-4-氨基-3-氟-2-羟基丁酰基}-2',3'-双脱氧卡那霉素 A； 1-N-(2R,3R)-4-氨基-氟-2-羟基丁酰基}-2',3'-双脱氧-2'-氟卡那霉素 A；1-N-(2R,3R)-4-氨基-3-氟-2-羟基丁酰基}-5-脱氧-5-氟卡那霉素 A； 1-N-((2R,3R)-4-氨基-3-氟-2-羟基丁酰基}-卡那霉素 B； 1-N-(2R,3R)-4-氨基-3-氟-2-羟基丁酰基}-3'-脱氧卡那霉素 B；1-N-(2R,3R)-4-氨基-3-氟-2-羟基丁酰基}-3',4'-双脱氧卡那霉素 B； 1-N-(2R,3R)-4-氨基-3-氟-2-羟基丁酰基}-5-脱氧-5-氟卡那霉素 B；1-N-(2R,3R)-4-amino-3-fluoro-2-hydrox- ybutyryl}-5,3'-dideoxy-5-fluorokanamycin B;和 1-N(2R,3R)-4-氨基-3-氟-2-羟基丁酰基}-5,3',4'-三脱氧-5-氟卡那霉素 B，它们都是治疗细菌感染的有用抗菌剂。
• Fluorination with aminosulfur trifluorides
  申请人：AIR PRODUCTS AND CHEMICALS, INC.

  公开号：EP0905109A1

  公开（公告）日：1999-03-31

  A fluorination method of oxygen and halogen sites with diaryl-, dialkoxyalkyl-, alkylalkoxyalkyl-, arylalkoxyalkyl- and cyclic aminosulfur trifluorides fluorinating reagents is disclosed.

  本发明公开了一种用二芳基、二烷氧基烷基、烷基烷氧基烷基、芳基烷氧基烷基和环状三氟化硫胺氟化试剂对氧和卤素位点进行氟化的方法。
• A characteristic redox reaction for N,N′-thiobisamines and some other S(II) compounds
  作者：Carlos Díaz

  DOI：10.1016/s0277-5387(00)84116-9

  日期：1985.1