N'-(naphthalen-1-ylmethylene)nicotinohydrazide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N'-(naphthalen-1-ylmethylene)nicotinohydrazide
• 英文别名: N-(naphthalen-2-ylmethylideneamino)pyridine-3-carboxamide
• 化学式: C₁₇H₁₃N₃O
• 分子量: 275.31
• InChiKey: TYJCONRBZCIAKR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N'-(naphthalen-1-ylmethylene)nicotinohydrazide 、 乙酸酐 生成 3-acetyl-2-(naphthalen-2-yl)-5-(pyridin-3-yl)-2,3-dihydro-1,3,4-oxadiazole
  参考文献：
  名称：

  Antibacterial activities of novel nicotinic acid hydrazides and their conversion into N -acetyl-1,3,4-oxadiazoles

  摘要：

  Synthesis of a series of novel N-acylhydrazones of nicotinic acid hydrazides 3a-j via condensation of nicotinic acid hydrazide 1 with the corresponding aldehydes and ketones is described. The series 3a-j was evaluated for in vitro antibacterial activity against two gram negative (Pseudomonas aeruginosa and Klebsiella pneumoniae) and two gram positive (Streptococcus pneumoniae and Staphylococcus aureus) bacteria. The zone of inhibition was measured using the disk diffusion method, and in vitro minimum inhibitory concentration indicating that compounds 3a and 3e were effective against P. aeruginosa with MICs of 0.220 and 0.195 mu g respectively. (C) 2014 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2014.10.029
• 作为产物：
  描述：

  3-吡啶甲酰肼 、 2-萘甲醛 以 乙醇 为溶剂， 生成 N'-(naphthalen-1-ylmethylene)nicotinohydrazide
  参考文献：
  名称：

  Antibacterial activities of novel nicotinic acid hydrazides and their conversion into N -acetyl-1,3,4-oxadiazoles

  摘要：

  Synthesis of a series of novel N-acylhydrazones of nicotinic acid hydrazides 3a-j via condensation of nicotinic acid hydrazide 1 with the corresponding aldehydes and ketones is described. The series 3a-j was evaluated for in vitro antibacterial activity against two gram negative (Pseudomonas aeruginosa and Klebsiella pneumoniae) and two gram positive (Streptococcus pneumoniae and Staphylococcus aureus) bacteria. The zone of inhibition was measured using the disk diffusion method, and in vitro minimum inhibitory concentration indicating that compounds 3a and 3e were effective against P. aeruginosa with MICs of 0.220 and 0.195 mu g respectively. (C) 2014 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2014.10.029

文献信息

• Antibacterial activities of novel nicotinic acid hydrazides and their conversion into N -acetyl-1,3,4-oxadiazoles
  作者：Rami Y. Morjan、Ahmed M. Mkadmh、Ian Beadham、Abdelrauof A. Elmanama、Mohammed R. Mattar、James Raftery、Robin G. Pritchard、Adel M. Awadallah、John M. Gardiner

  DOI：10.1016/j.bmcl.2014.10.029

  日期：2014.12

  Synthesis of a series of novel N-acylhydrazones of nicotinic acid hydrazides 3a-j via condensation of nicotinic acid hydrazide 1 with the corresponding aldehydes and ketones is described. The series 3a-j was evaluated for in vitro antibacterial activity against two gram negative (Pseudomonas aeruginosa and Klebsiella pneumoniae) and two gram positive (Streptococcus pneumoniae and Staphylococcus aureus) bacteria. The zone of inhibition was measured using the disk diffusion method, and in vitro minimum inhibitory concentration indicating that compounds 3a and 3e were effective against P. aeruginosa with MICs of 0.220 and 0.195 mu g respectively. (C) 2014 Published by Elsevier Ltd.