家蝇磷 | 919-54-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机二硫代磷酸及其衍生物
• 中文名称: 家蝇磷
• 英文名称: O,O-diethyl S-carboethoxymethyl phosphorodithioate
• 英文别名: ethyl diethoxydithiophosphorylacetate；acethion；diethoxythiophosphorylsulfanyl-acetic acid ethyl ester；Dithiophosphorsaeure-S-aethoxycarbonylmercaptomethylester-O,O'-diaethylester；Diaethoxythiophosphorylmercapto-essigsaeure-aethylester；O,O-Diethyl-S-ethoxycarbonylmethyl-dithiophosphat-<³⁵S>；ethyl 2-diethoxyphosphinothioylsulfanylacetate
• CAS: 919-54-0
• 化学式: C₈H₁₇O₄PS₂
• mdl: MFCD00543034
• 分子量: 272.326
• InChiKey: AISZOMRXKKCPIS-UHFFFAOYSA-N

物化性质

• 沸点：
  137 °C(Press: 1.5 Torr)
• 密度：
  1.1800
• 颜色/状态：
  Liquid
• 溶解度：
  In water, 69.1 mg/L at 25 °C (est)
• 蒸汽压力：
  5.34X10-4 mm Hg at 25 °C (est)
• 分解：
  When heated to decomposition it emits very toxic fumes of /phosphorus and sulfur oxides/.

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  15
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.875
• 拓扑面积：
  102
• 氢给体数：
  0
• 氢受体数：
  6

ADMET

代谢

乙氧亚磷酰的降解是迅速的，77-88%的注射剂量在处理后0.5小时内以氯仿可提取物形式出现。色谱分离和分析表明主要代谢物是乙氧亚磷酰酸。还发现了一些单和二乙基磷酰亚硫酰酸。

Degradation of acethion was rapid & 77-88% of injected dose appeared as chloroform extractables within 0.5 hr after treatment. Chromatographic separation & anal showed principal metabolite to be acethion acid. Some mono- & diethyl phosphorodithionic acids were also found.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 副作用

其他毒物 - 有机磷

Other Poison - Organophosphate

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

毒理性

• 解毒与急救

/SRP:/ 基本治疗：建立专利气道（如有需要，使用口咽或鼻咽气道）。如有必要，进行吸痰。可能需要积极的气道控制。观察呼吸不足的迹象，如有必要，协助通气。通过非循环呼吸面罩以10至15升/分钟的速度给予氧气。监测肺水肿，如有必要，进行治疗……。监测休克，如有必要，进行治疗……。预期癫痫发作，如有必要，进行治疗……。对于眼睛污染，立即用水冲洗眼睛。在转运过程中，用0.9%的生理盐水（NS）连续冲洗每只眼睛……。不要使用催吐剂。对于摄入，如果患者能吞咽、有强烈的干呕反射且不流口水，则用水冲洗口腔，并给予5毫升/千克，最多200毫升的水进行稀释。给予活性炭……。 /有机磷及其相关化合物/

/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Aggressive airway control may be needed. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Organophosphates and related compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

/SRP:/ 高级治疗：对于无意识、严重肺水肿或严重呼吸困难的病人，考虑进行口咽或鼻咽气管插管以控制气道。使用气囊面罩的正压通气技术可能有益。监测心率和必要时治疗心律失常...开始静脉输注D5W /SRP: "保持开放"，最低流速/。如果出现低血容量的迹象，使用0.9%生理盐水（NS）或乳酸钠林格氏液（LR）。对于伴有低血容量迹象的低血压，谨慎给予液体，并考虑在血容量正常的情况下使用血管加压药。注意液体过载的迹象...给予阿托品。在给予阿托品之前纠正低氧血症...给予氯磷定（2 PAM）。仅在医生的直接指示下使用...用足够的阿托品化和纠正低氧血症来治疗癫痫。在罕见情况下，可能需要使用地西泮或劳拉西泮...注意液体过载的迹象...使用丙美卡因盐酸来协助眼部冲洗... /有机磷及其相关化合物/

/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously and consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Administer atropine. Correct hypoxia before giving atropine ... . Administer pralidoxime chloride (2 PAM). USE UNDER DIRECT PHYSICIAN ORDERS ONLY ... . Treat seizures with adequate atropinization and correction of hypoxia. In rare cases diazepam or lorazepam may be necessary ... . Watch for signs of fluid overload ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Organophosphates and related compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 医疗监测

除非以下五个条件全部满足，否则很少有必要做出轻度到中度急性有机磷农药中毒的最终诊断：1. 有明确的有机磷农药接触史。2. 从最后一次接触至发病的潜伏期不超过几小时。3. 临床表现中存在以下大多数或全部症状：头痛、视力模糊、虚弱、胸部紧缩和瞳孔缩小。4. 血浆和红细胞胆碱酯酶活性降低到基线值的50%以下。由于人群中红细胞胆碱酯酶的正常范围很广，即使在报告的“正常”水平下也可能出现症状。5. 急性病程不超过48小时。急性有机磷中毒的经典表现包括病史、有机磷接触的证据（大蒜味）、胆碱能过多的体征/症状、使用阿托品或普鲁碘胺后症状改善，以及血液中胆碱酯酶的抑制。/有机磷农药中毒/

A final diagnosis of mild to moderate acute organophosphate pesticide poisoning is rarely justified unless all of the following five conditions are present: 1. A definite history of exposure to an organophosphate pesticide. 2. A latent interval of not more than a few hours between that last exposure and the onset of illness. 3. A clinical picture in which most or all of the following signs or symptoms are present: headache, blurred vision, weakness, tightness in chest, and constricted pupils. 4. Reduction of plasma and RBC cholinesterase activity to a level substantially below 50% of baseline values. Because of the wide normal range of RBC cholinesterase in the population, symptoms may be present with reported "normal" levels. 5. An acute illness that is not substantially longer than 48 hours. The classic presentation for acute organophosphate toxicity includes history, evidence of exposure to organophosphate (garlic odor), signs/symptoms of cholinergic excess, improvement with atropine or pralidoxime, and inhibition of cholinesterase in blood. /Organophosphate pesticide poisoning/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 人类毒性摘录

有机磷杀虫剂的毒性作用可能包括厌食、腹痛、恶心、呕吐、腹泻、失禁、眼部变化、虚弱、呼吸困难、支气管痉挛、流泪、唾液和出汗增多、心动过缓、由于窒息导致的低血压或高血压、发绀以及眼睑、舌头、面部和颈部的肌肉抽搐，可能会进展到癫痫发作。中枢神经系统症状包括不安、焦虑、眩晕、嗜睡、震颤、共济失调、抑郁、混乱和昏迷。死亡可能由于呼吸或心血管系统的抑制。目前使用的有机磷杀虫剂引起的神经病变似乎是一个罕见的问题。

/SIGNS AND SYMPTOMS/ Toxic effects may include anorexia, abdominal cramps, nausea, vomiting, diarrhea, incontinence, eye changes, weakness, dyspnea, bronchospasm, lacrimation, increased salivation and sweating, bradycardia, hypotension or hypertension due to asphyxia, cyanosis, and muscular twitching of the eyelids, tongue, face, and neck, possibly progressing to convulsions. Central nervous system symptoms include restlessness, anxiety, dizziness, drowsiness, tremor, ataxia, depression, confusion, and coma. Death may occur from depression of the respiratory or cardiovascular system. Neuropathy appears to be a rare problem with the organophosphorus insecticides now in use. /Organophosphorus insecticides/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

所有这些物质在肝脏和其他组织中都会经历水解降解，通常在吸收后的几小时内。降解产物会通过尿液和粪便排出体外。/有机磷农药/

All undergo hydrolytic degradation in liver & other tissues, usually within hours of absorption. Degradation products are...excreted in urine & feces. /Organophosphate pesticides/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

许多有机磷杀虫剂会通过牛奶排出体外...有机磷杀虫剂

Many of /the organophosphorus insecticides/ are excreted in the milk ... /Organophosphorus insecticides/

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 海关编码：
  2930909064
• 储存条件：
  库房应保持通风、低温和干燥，并将储存的物资与食品原料分开进行储运。

制备方法与用途

类别：农药

毒性分级：中毒

急性毒性：

• 大鼠 LD50: 1100 毫克/公斤
• 小鼠 LD50: 1200 毫克/公斤

可燃性危险特性：燃烧时会产生有毒的磷氧化物和硫氧化物气体

储运特性：需存放在通风、低温且干燥的地方，并与食品原料分开存放及运输

灭火剂：干粉、泡沫或砂土

反应信息

• 作为反应物：
  描述：

  家蝇磷 在 sodium hydroxide 、 一水合肼 作用下， 以 乙醇 为溶剂， 反应 76.0h， 生成 3-(diethoxyphosphinothioylsulfanylmethyl)-4-(4-methylphenyl)-1H-1,2,4-triazole-5-thione
  参考文献：
  名称：

  Chande, Madhukar S.; Jagtap, Rajendra S.; Sharma, R. N., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1995, vol. 34, # 10, p. 923 - 926

  摘要：

  DOI：
• 作为产物：
  描述：

  氯乙酸乙酯 、 二硫代磷酸二乙酯 在 三乙胺 、 苯 作用下， 生成 家蝇磷
  参考文献：
  名称：

  FR1133785

  摘要：

  公开号：

文献信息

• [EN] MICROBIOCIDAL OXADIAZOLE DERIVATIVES<br/>[FR] DÉRIVÉS D'OXADIAZOLE MICROBIOCIDES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2017157962A1

  公开（公告）日：2017-09-21

  Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as a pesticides, especially fungicides.

  式(I)的化合物，其中取代基如权利要求1所定义，作为杀虫剂特别是杀菌剂有用。
• Thieno-pyrimidine compounds having fungicidal activity
  申请人：Brewster Kirkland William

  公开号：US20070093498A1

  公开（公告）日：2007-04-26

  The present invention relates to thieno[2,3-d]-pyrimidine compounds having fungicidal activity.

  本发明涉及具有杀真菌活性的噻吩[2,3-d]-嘧啶化合物。
• [EN] INSECTICIDAL TRIAZINONE DERIVATIVES<br/>[FR] DÉRIVÉS DE TRIAZINONE INSECTICIDES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2013079350A1

  公开（公告）日：2013-06-06

  Compounds of the formula (I) or (I'), wherein the substituents are as defined in claim 1, are useful as pesticides.

  式(I)或(I')的化合物，其中取代基如权利要求1所定义的那样，可用作杀虫剂。
• Novel insecticides
  申请人：Syngenta Participations AG

  公开号：EP2540718A1

  公开（公告）日：2013-01-02

  Compounds of formula I wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts and all stereoisomers and tautomeric forms of the compounds of formula I can be used as insecticides and can be prepared in a manner known per se.

  式I的化合物 其中取代基如权利要求1所定义，并且式I化合物的农药可接受盐以及所有立体异构体和互变异构形式可用作杀虫剂，并且可以按照已知的方法制备。
• Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto
  申请人：Dow AgroSciences LLC

  公开号：US20180279612A1

  公开（公告）日：2018-10-04

  This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).

  这份披露涉及具有对节肢动物门、软体动物门和线虫门害虫具有杀虫效用的分子领域，用于生产此类分子的过程，用于此类过程的中间体，含有此类分子的杀虫组合物，以及使用此类杀虫组合物对抗此类害虫的过程。这些杀虫组合物可以用作螨虫剂、杀虫剂、螨虫剂、软体动物杀虫剂和线虫杀虫剂。本文件披露了具有以下式（“式一”）的分子。