灭蚜磷 | 2595-54-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机二硫代磷酸及其衍生物
• 中文名称: 灭蚜磷
• 中文别名: 苯噻草胺；灭蚜蜱；2-甲-4-氯丁酸；灭芽磷；灭芽蜱
• 英文名称: mecarbam
• 英文别名: Caswell No. 340；ethyl N-(2-diethoxyphosphinothioylsulfanylacetyl)-N-methylcarbamate
• CAS: 2595-54-2
• 化学式: C₁₀H₂₀NO₅PS₂
• 分子量: 329.378
• InChiKey: KLGMSAOQDHLCOS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  19
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  123
• 氢给体数：
  0
• 氢受体数：
  7

ADMET

代谢

老鼠主要通过水解、氧化脱硫和降解氨基甲酸基团来代谢甲卡姆，O-脱乙基化是一个次要途径。在尿液中至少发现了10种非结合代谢物和1种结合物，但几乎没有或没有未改变的甲卡姆。口服给予哺乳山羊的甲卡姆主要在氨基甲酸基团代谢，伴有少量的O-脱乙基化；尿液中至少出现了6种非结合代谢物。

Rats metabolized mecarbam primarily by hydrolysis, oxidative desulfuration and degradation of the carbamoyl moiety; O-deethylation was a minor pathway. At least 10 nonconjugated metabolites and 1 conjugate were found in the urine, but little or no unchanged mecarbam. Mecarbam orally administered to a lactating goat was metabolized mainly at the carbamoyl moiety, with minor O-deethylation; at least 6 nonconjugated metabolites appeared in the urine.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 暴露途径

该物质可以通过吸入其气溶胶、通过皮肤接触以及吞食被身体吸收。

The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion.

来源:ILO-WHO International Chemical Safety Cards (ICSCs)

毒理性

• 吸入症状

晕眩。恶心。肌肉抽搐。出汗。瞳孔收缩。肌肉痉挛。过度流涎。呕吐。腹泻。呼吸困难。抽搐。咳嗽。视力模糊。昏迷。

Dizziness. Nausea. Muscle twitching. Sweating. Pupillary constriction. Muscle cramps. Excessive salivation. Vomiting. Diarrhoea. Laboured breathing. Convulsions. Cough. Blurred vision. Unconsciousness.

来源:ILO-WHO International Chemical Safety Cards (ICSCs)

毒理性

• 皮肤症状

见吸入。

See Inhalation.

来源:ILO-WHO International Chemical Safety Cards (ICSCs)

毒理性

• 摄入症状

见吸入。

See Inhalation.

来源:ILO-WHO International Chemical Safety Cards (ICSCs)

毒理性

• 副作用

神经毒素 - 主要影响运动神经

Neurotoxin - Predominantly motor

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

吸收、分配和排泄

单次口服给予大鼠(14)C甲卡朋后，组织中肝和肾脏的浓度最高；给药后48小时内，仍可在胃中找到一些标记。给予放射性标记甲卡朋静脉注射的大鼠，给药后前40分钟内残留物下降最快；6小时内血液中的移除几乎完全。单次口服给予放射性标记甲卡朋的大鼠，48小时内约有80-92%的剂量通过尿液排出，2-3%通过粪便排出，0.2-5%作为呼出的(14)CO2排出。尿液中放射性主要与七种主要极性代谢物相关；尿液中几乎没有或没有未改变的甲卡朋。奶牛饮食中连续几天以10 ppm甲卡朋的含量，在牛奶中的排出水平不超过10 ppm。

Following single oral doses of (14)C mecarbam to rats, tissue levels were highest in the liver and kidneys; some label was still found in the stomach up to 48 hr after administration. In rats given radiolabeled mecarbam iv, residues declined most rapidly during the first 40 min after administration; removal from the blood was nearly complete in 6 hr. Rats given single oral doses of radiolabeled mecarbam eliminated about 80-92% of the dose in the urine, 2-3% in the feces, and 0.2-5% as exhaled (14)CO2 within 48 hr. Urinary radioactivity was associated mainly with seven major polar metabolites; little or no unchanged mecarbam was found in the urine. Mecarbam in the diet of cows for days at 10 ppm was excreted in the milk at levels not exceeding 10 ppm.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

一位19岁的孕妇自杀性中毒，摄入了含有68克/升S-(N-乙氧羰基-N-甲基氨基甲酰甲基)O,O-二乙基硫代磷酰氧酸（商品名包括Murfotox）的水溶液甲萘威（CR Worthing (Ed)，《农药手册》，第6版，BCPC，1980年）的未知量。该农药穿过胎盘屏障，导致胎儿死亡。对母体-胎儿几种组织和体液中的甲萘威进行毒理分析，揭示了其分布情况。分析是通过薄层色谱和气液色谱进行的。所述案例旨在指出甲萘威穿过胎盘屏障的容易程度，其在肺中的高浓度以及在胎儿组织中比母体组织明显更高的浓度。

- A suicidal poisoning committed by a 19-year-old pregnant woman, who ingested an unknown quantity of an aqueous solution mecarbam (trade name includes Murfotox) containing 68 g/l of S-(N-ethoxycarbonyl-N-methylcarbamoyl methyl) O,O-diethyl phosphorodithioate (CR Worthing (Ed), The Pesticide Manual, 6th end, BCPC, 1980) is described. The pesticide crossed the placental Barrier and caused the death of the fetus. Toxicologic analysis of mecarbam in several tissues and fluids of mother-fetus revealed its distribution. The analysis was performed by thin-layer chromatography and gas-1iquid chromatography. The case described serves to point out the ease with which mecarbam crossed the placental barrier, its high concentration in the lungs and the considerably higher concentrations in fetal than in mother's tissues.

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 储存条件：
  APPROX 4°C

制备方法与用途

mecarbam 是一种杀虫剂。

文献信息

• [EN] BICYCLYL-SUBSTITUTED ISOTHIAZOLINE COMPOUNDS<br/>[FR] COMPOSÉS ISOTHIAZOLINE SUBSTITUÉS PAR UN BICYCLYLE
  申请人：BASF SE

  公开号：WO2014206910A1

  公开（公告）日：2014-12-31

  The present invention relates to bicyclyl-substituted isothiazoline compounds of formula (I) wherein the variables are as defined in the claims and description. The compounds are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to a method for controlling invertebrate pests by using these compounds and to plant propagation material and to an agricultural and a veterinary composition comprising said compounds.

  本发明涉及公式（I）中变量如索权和说明中所定义的自行车基取代异噻唑啉化合物。这些化合物对抗或控制无脊椎动物害虫，特别是节肢动物害虫和线虫方面具有用途。该发明还涉及一种通过使用这些化合物来控制无脊椎动物害虫的方法，以及包含所述化合物的植物繁殖材料、农业和兽医组合物。
• [EN] AZOLINE COMPOUNDS<br/>[FR] COMPOSÉS AZOLINE
  申请人：BASF SE

  公开号：WO2015128358A1

  公开（公告）日：2015-09-03

  The present invention relates to azoline compounds of formula (I) wherein A, B1, B2, B3, G1, G2, X1, R1, R3a, R3b, Rg1 and Rg2 are as defined in the claims and the description. The compounds are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to a method for controlling invertebrate pests by using these compounds and to plant propagation material and to an agricultural and a veterinary composition comprising said compounds.

  本发明涉及式（I）的噁唑啉化合物，其中A、B1、B2、B3、G1、G2、X1、R1、R3a、R3b、Rg1和Rg2如权利要求和描述中所定义。这些化合物对抗或控制无脊椎动物害虫，特别是节肢动物害虫和线虫方面具有用途。该发明还涉及一种利用这些化合物控制无脊椎动物害虫的方法，以及包括所述化合物的植物繁殖材料、农业和兽医组合物。
• [EN] MICROBIOCIDAL OXADIAZOLE DERIVATIVES<br/>[FR] DÉRIVÉS D'OXADIAZOLE MICROBIOCIDES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2017157962A1

  公开（公告）日：2017-09-21

  Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as a pesticides, especially fungicides.

  式(I)的化合物，其中取代基如权利要求1所定义，作为杀虫剂特别是杀菌剂有用。
• Thieno-pyrimidine compounds having fungicidal activity
  申请人：Brewster Kirkland William

  公开号：US20070093498A1

  公开（公告）日：2007-04-26

  The present invention relates to thieno[2,3-d]-pyrimidine compounds having fungicidal activity.

  本发明涉及具有杀真菌活性的噻吩[2,3-d]-嘧啶化合物。
• [EN] INSECTICIDAL TRIAZINONE DERIVATIVES<br/>[FR] DÉRIVÉS DE TRIAZINONE INSECTICIDES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2013079350A1

  公开（公告）日：2013-06-06

  Compounds of the formula (I) or (I'), wherein the substituents are as defined in claim 1, are useful as pesticides.

  式(I)或(I')的化合物，其中取代基如权利要求1所定义的那样，可用作杀虫剂。