害草净 | 845-52-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 中文名称: 害草净
• 中文别名: 2,4-双[(3-甲氧基丙基)氨基]-6-(甲硫基)间三嗪
• 英文名称: lambast
• 英文别名: 2,4-bis (3-methoxypropylamino)-6-methyl-thio-s-triazine；N,N'-bis-(3-methoxy-propyl)-6-methylsulfanyl-[1,3,5]triazine-2,4-diamine；2,4-bis (3-methoxylpropylamino)-6-methylthio-S-triazine；2-N,4-N-bis(3-methoxypropyl)-6-methylsulfanyl-1,3,5-triazine-2,4-diamine
• CAS: 845-52-3
• 化学式: C₁₂H₂₃N₅O₂S
• 分子量: 301.413
• InChiKey: FBMDQVBGIYSDTI-UHFFFAOYSA-N

物化性质

• 熔点：
  55-59 °C
• 沸点：
  481.6±55.0 °C(Predicted)
• 密度：
  1.17±0.1 g/cm3(Predicted)
• 颜色/状态：
  CRYSTALS
• 溶解度：
  3.32e-04 M
• 稳定性/保质期：
  燃烧会产生有毒的氮氧化物和硫氧化物气体。

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  20
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  107
• 氢给体数：
  2
• 氢受体数：
  8

ADMET

代谢

所有这些除草剂（甲氧基和甲基巯基取代的 三嗪除草剂）在被摄入时都会迅速被吸收和代谢；氨基脱烷基化和侧链氧化是主要的解毒反应。三嗪的巯基衍生物还可能经历亚磺酰化，随后与肝脏的谷胱甘肽反应，产生巯基尿酸衍生物。/s-三嗪/

All of these herbicides /methoxy & methylthio substituted triazine herbicides/ are rapidly absorbed and metabolized when ingested; amine dealkylation and side chain oxidation are the predominant detoxification reactions. The mercapto derivatives of triazine may also undergo sulfoxidation followed by reaction with hepatic glutathione to yield mercapturic acid derivatives. /s-Triazines/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 医疗监测

初步医疗检查，以检测中枢神经系统、肝脏、心脏、肾脏、肺和皮肤的慢性疾病，以及内分泌或免疫系统的紊乱，应该……/保护/易感个体。……定期对内部器官、皮肤和眼睛进行医疗检查，以避免慢性职业中毒。如果需要，应包括实验室测试和贴片测试。/除草剂/

Preliminary medical exam to detect chronic diseases of CNS, liver, heart, kidneys, lung & skin, as well as endocrinological or immunological disturbances, should ... /protect/ susceptible individuals. ... Periodical medical exam of internal organs, skin & eyes is important to avoid chronic occupational intoxications. It should include lab tests & patch tests if necessary. /Herbicides/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

在绵羊中，单次口服剂量为250毫克/千克/Lambast/立即产生了共济失调、不协调和跛行，2小时后出现...抑郁。

In sheep a single oral dose of 250 mg/kg /Lambast/ produced immediate ataxia, uncoordination & lameness, followed after 2 hr by ... depression.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性值

大鼠经口LD50 1400毫克/千克（可乳化浓缩剂）

LD50 Rat oral 1400 mg/kg (emulsifiable concentrate)

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性值

大鼠口服LD50 5700毫克/千克

LD50 Rat oral 5700 mg/kg

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

所有这些除草剂（甲氧基或甲基硫代取代三嗪除草剂）在被摄入时都会迅速被吸收... 大多数化合物的代谢物在72小时内通过尿液和粪便排出。/s-三嗪/

All of these herbicides /methoxy or methylthio substituted triazine herbicides/ are rapidly absorbed ... when ingested ... Metabolites of most compounds are excreted in urine & feces within 72 hr. /s-Triazines/

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 海关编码：
  2933699090

制备方法与用途

类别：农药
毒性分级：中毒
急性毒性（口服）：大鼠 LD50 为 1400 毫克/公斤
可燃性危险特性：燃烧时产生有毒的氮氧化物和硫氧化物气体
储运特性：应存放在通风、低温和干燥的地方，并与食品原料分开存放和运输
灭火剂：干粉、泡沫或砂土

文献信息

• Herbicidal compositions which contain a thiocarbamate and an organophosphorous compound and their application
  申请人：STAUFFER CHEMICAL COMPANY

  公开号：EP0010178A1

  公开（公告）日：1980-04-30

  Herbicidally active thiocarbamates are employed in combination with organophosphorothioates, the latter in sufficient qualtity to prevent soil degradation of the former. As a result, the herbicidal effectiveness of the thiocarbamate is significantly enhanced and prolonged, rendering a single application of the herbicide effective over a longer period of time.

  具有除草活性的硫代氨基甲酸酯与有机硫代磷酸酯结合使用，后者的质量足以防止前者在土壤中降解。因此，硫代氨基甲酸酯类除草剂的除草效果明显增强并延长，使除草剂的单次施用在更长的时间内有效。
• Impregnated porous granules with slow-release pore membranes, and process for the manufacture thereof
  申请人：STAUFFER CHEMICAL COMPANY

  公开号：EP0005302A2

  公开（公告）日：1979-11-14

  Open-ended pores of a porous granule are filled with a liquid material which is at least partially immiscible with water, and sealed with a porous polyurea membrane which limits the release rate of the material into the surrounding medium. The membrane is formed by (a) applying to the bare granule an organic solution comprising the liquid material and an organic polyisocyanate, followed by (b) applying to the granule an aqueous solution comprising water and a catalytic amount of a catalyst selected from the group consisting of a basic organic tertiary amine and an alkyl tin carboxylate.

  在多孔颗粒的开口孔中填充至少部分与水不相溶的液态材料，并用多孔聚脲膜密封，以限制材料释放到周围介质中的速度。聚脲膜的形成过程如下 (a) 在裸颗粒上涂抹由液态材料和有机多异氰酸酯组成的有机溶液，然后 (b) 对颗粒施加水溶液，该水溶液由水和一定量的催化剂组成，催化剂选自碱性有机叔胺和烷基羧酸锡。
• Herbicide compositions of extended soil life
  申请人：STAUFFER CHEMICAL COMPANY

  公开号：EP0038945A2

  公开（公告）日：1981-11-04

  Herbicidally active thiolcarbamates are employed in combination with certain substituted carbamates having the formula in which R4 and R5 are each methyl, R4 and R5 conjointly form C1-C4 alkylenedioxy, R4 is -CF3 and R5 is hydrogen, or R4 is -CH2Br and R5 is hydrogen. In a typical application, the carbamate is included in sufficient quantity to lessen the rate of soil degradation of the thiolcarbamate. As a result, the herbicidal effectiveness of the thiolcarbamate is enhanced and prolonged, rendering a single application of the herbicide effective over a longer period of time.

  具有除草活性的硫代氨基甲酸乙酯可与某些取代的氨基甲酸酯结合使用，这些氨基甲酸酯的式中 R4 和 R5 分别为甲基，R4 和 R5 共同形成 C1-C4 亚烷基二氧基，R4 为-CF3，R5 为氢，或 R4 为-CH2Br，R5 为氢。 在典型的应用中，氨基甲酸酯的用量足以降低硫代氨基甲酸乙酯在土壤中的降解速度。 因此，硫代氨基甲酸乙酯的除草效果得到增强和延长，使除草剂的单次施用在更长的时间内有效。
• Certain 2-(2-substituted benzoyl)-1,3-cyclohexanediones
  申请人：STAUFFER CHEMICAL COMPANY

  公开号：EP0090262A2

  公开（公告）日：1983-10-05

  Compounds having the structural formula wherein R and R' are hydrogen or C1-C4 alkyl; R2 is chlorine, bromine or iodine; R3 is hydrogen, iodine or chlorine; and R5 is hydrogen, halogen, C1-C4 alkyl, C1-C4 alkoxy, nitro, or trifluormethyl as herbicides.

  具有以下结构式的化合物：R 和 R' 是氢或 C1-C4 烷基；R2 是氯、溴或碘；R3 是氢、碘或氯；R5 是氢、卤素、C1-C4 烷基、C1-C4 烷氧基、硝基或三氟甲基。
• Certain 2-(2-(substituted phenyl)acetyl)-1,3-cyclohexanediones
  申请人：STAUFFER CHEMICAL COMPANY

  公开号：EP0162336A1

  公开（公告）日：1985-11-27

  Compounds having the structural formula wherein R,, Rz, R3, R4 and R5 are the same or different and are selected from the group consisting of hydrogen, chlorine, bromine, iodine, nitro, alkyl having from 1 to 4 carbon atoms, alkoxy having from 1 to 4 carbon atoms, trifluoromethyl, trifluoromethoxy, cyano, alkylsulfonyl, and alkylthio having from 1 to 4 carbon atoms, and wherein R2 and R3 or R3 and R4 together can be methylene or ethylenedioxy.

  具有结构式的化合物，其中 R、Rz、R3、R4 和 R5 相同或不同，并选自氢、氯、溴、碘、硝基、具有 1 至 4 个碳原子的烷基、具有 1 至 4 个碳原子的烷氧基、三氟甲基、三氟甲氧基、氰基、烷基磺酰基和具有 1 至 4 个碳原子的烷硫基组成的组，其中 R2 和 R3 或 R3 和 R4 合在一起可以是亚甲基或亚乙二氧基。