(1-乙基-1H-吡咯-2-基)甲胺 | 74402-54-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: (1-乙基-1H-吡咯-2-基)甲胺
• 英文名称: N-ethyl-2-aminomethylpyrrole
• 英文别名: (1-Ethyl-1H-pyrrol-2-yl)methanamine；(1-ethylpyrrol-2-yl)methanamine
• CAS: 74402-54-3
• 化学式: C₇H₁₂N₂
• mdl: MFCD15730262
• 分子量: 124.186
• InChiKey: FFFHBHWCZONDKN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  31
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (1-乙基-1H-吡咯-2-基)甲胺 在 sodium methylate 、 三乙胺 作用下， 以 甲醇 、 Petroleum ether 为溶剂， 反应 72.0h， 生成 1-(1-Ethyl-1H-pyrrol-2-ylmethyl)-azetidin-3-ol
  参考文献：
  名称：

  Higgins, Robert H.; Watson, Monique R.; Faircloth, William J., Journal of Heterocyclic Chemistry, 1988, vol. 25, p. 383 - 387

  摘要：

  DOI：

文献信息

• A SET OF GELDANAMYCIN DERIVATIVES AND THEIR PREPARATION METHODS
  申请人：Institute Of Medicinal Biotechnology, Chinese Academy of Medical Sciences

  公开号：EP2253621A1

  公开（公告）日：2010-11-24

  A set of geldanamycin derivatives and their preparation methods. Pharmaceutical compositions comprising the said compounds as an active ingredient which are used as antivirus and antitumor agents. The said derivatives are used in the manufacture of heat shock protein 90(Hsp 90) inhibiting agents which have the utility as antivirus and antitumor agents.

  一组格尔丹霉素衍生物及其制备方法。包含所述化合物作为活性成分的药物组合物，用作抗病毒和抗肿瘤药剂。所述衍生物用于制造具有抗热休克蛋白90（Hsp 90）抑制作用的药剂，具有作为抗病毒和抗肿瘤药剂的用途。
• Imido carbonate compound, production thereof and uses thereof as reagent
  申请人：Ogura; Haruo

  公开号：US04341707A1

  公开（公告）日：1982-07-27

  A new carbonate compound which is N,N'-di-succinimidyl carbonate, N,N'-diphthalimidyl carbonate or N,N'-bis(5-norbornene-2,3-dicarboxyimidyl) carbonate is produced by reacting an N-hydroxy compound of the formula R-OH wherein R is succinimido, phthalimido or 5-norbornene-2,3-dicarboximido group, with a silylating agent, followed by reacting the resultant silylated product with phosgene, or alternatively by reacting said N-hydroxy compound with trichloromethyl chloroformate either in the molten state or in the presence of a non-polar organic solvent such as xylene. This new carbonate compound is useful not only as a reagent for forming active esters from amino acid but also as a reagent for introducing a carbonyl group between a pair of amino groups, a pair of amino and hydroxyl groups or a pair of amino and mercapto groups, for producing an isothiocyanate from a dithicarbamic acid by removal of hydrogen sulfide from the latter, and for producing acrylic acid derivatives from N-protected serine by dehydration of the latter.

  通过将化合物R-OH（其中R是琥珀酰亚胺基团，邻苯二甲酰亚胺基团或5-去氢莫尔宁-2,3-二羧酰亚胺基团）与硅烷化剂反应，然后将所得的硅烷化产物与光气反应，或者通过将所述N-羟基化合物与三氯甲基氯甲酸酯在熔融状态下或在类似二甲苯的非极性有机溶剂的存在下反应，可以制备一种新的碳酸酯化合物，其为N，N'-二琥珀酰亚胺基碳酸酯，N，N'-二邻苯二甲酰亚胺基碳酸酯或N，N'-双（5-去氢莫尔宁-2,3-二羧酰亚胺基）碳酸酯。这种新的碳酸酯化合物不仅可用作从氨基酸形成活性酯的试剂，还可用作在一对氨基基团、一对氨基和羟基基团或一对氨基和巯基基团之间引入羰基基团的试剂，通过从后者中去除硫化氢从二硫代氨基甲酸生成异硫氰酸酯，以及通过从N-保护丝氨酸脱水生成丙烯酸衍生物的试剂。
• Set of Geldanamycin Derivatives and Their Preparation Methods
  申请人：Li Zhuorong

  公开号：US20100311694A1

  公开（公告）日：2010-12-09

  A set of geldanamycin derivatives and their preparation methods. Pharmaceutical compositions comprising the said compounds as an active ingredient which are used as antivirus and antitumor agents. The said derivatives are used in the manufacture of heat shock protein 90 (Hsp 90) inhibiting agents which have the utility as antivirus and antitumor agents.

  一组格尔达纳霉素衍生物及其制备方法。包含所述化合物作为活性成分的制药组合物，用作抗病毒和抗肿瘤剂。所述衍生物用于制造抑制热休克蛋白90（Hsp 90）的药剂，具有作为抗病毒和抗肿瘤剂的功效。
• Thiophene-carboxamide derivatives and their pharmaceutical use
  申请人：LILLY S.A.

  公开号：EP0371594A1

  公开（公告）日：1990-06-06

  A pharmaceutical compound of the formula in which R¹, R² and R³ independently are hydrogen, hydroxy, halo, nitro, amino, C₂₋₅ acylamino, C₁₋₄ alkyl, -CHO, -CH₂OH, -CH₂OC₁₋₄ alkyl, -COOH, -COC₁₋₃ alkyl, -CH(OH)C₁₋₃ alkyl, C₁₋₄ alkoxy, C₂₋₄ alkenyloxy, C₁₋₄ alkylthio, C₁₋₄ alkylsulphinyl, C₁₋₄ alkylsulphonyl, N-substituted heterocyclyl, optionally substituted phenyl, optionally substituted phenylthio, option­ally substituted phenylsulphinyl, optionally substituted phenylsulphonyl or optionally substituted phenylsulphonamido, or R¹ and R² together form a C₁₋₅ alkylene bridge; provided that at least one of R² and R³ is C₁₋₄ alkoxy or C₂₋₄ alkenyl­oxy; and X is (i) -(CH₂)nN(R⁴)₂ where each R⁴ independently is C₁₋₄ alkyl, C₂₋₄ alkenyl or optionally substituted C₆H₅CH₂-, and n is 1, 2 or 3, or (ii) a 5- to 8-membered alicyclic group containing one or two nitrogen atoms and directly attached to the amido nitrogen or attached by a C₁₋₃ alkylene chain; and salts and esters thereof.

  一种药物化合物，其化学式为 其中 R¹、R² 和 R³ 独立地为氢、羟基、卤代、硝基、氨基、C₂₋₅酰氨基、C₁₋₄ 烷基、-CHO、-CH₂OH、-CH₂OC、-CH₂₁₋₄ 烷基、-COOH、-COC₁₋₃烷基、-CH(OH)C₁₋₃烷基、C₁₋₄ 烷氧基、C₂₋₄烯氧基、C₁₋₄ 烷硫基、C₁₋₄ 烷硫基、C₁₋₄烷基磺酰基、N-取代的杂环基、任选取代的苯基、任选取代的苯硫基、任选取代的苯基亚磺酰基、任选取代的苯基磺酰基或任选取代的苯基磺酰氨基，或 R¹ 和 R² 共同形成 C₁₋₅亚烷基桥；条件是 R² 和 R³ 中至少有一个是 C₁₋₄ 烷氧基或 C₂₋₄ 烯氧基；和 X 是 (i) -(CH₂)nN(R⁴)₂ 其中每个 R⁴ 独立地是 C₁₋₄ 烷基、C₂₋₄ 烯基或任选取代的 C₆H₅CH₂-，且 n 是 1、2 或 3、或 (ii) 直接连接到氨基氮或通过 C₁₋₃ 亚烷基链连接的含有一个或两个氮原子的 5 至 8 元脂环基团；及其盐类和酯类。
• JPS552650A
  申请人：——

  公开号：JPS552650A

  公开（公告）日：1980-01-10