(1-甲基-1H-吲唑-4-基)甲胺 | 1144044-68-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡唑类
• 中文名称: (1-甲基-1H-吲唑-4-基)甲胺
• 英文名称: (1-methyl-1H-indazol-4-yl)methanamine
• 英文别名: (1-methylindazol-4-yl)methanamine
• CAS: 1144044-68-7
• 化学式: C₉H₁₁N₃
• mdl: MFCD12028598
• 分子量: 161.206
• InChiKey: PHNWDOCBKIJZPF-UHFFFAOYSA-N

物化性质

• 沸点：
  312.5±17.0 °C(Predicted)
• 密度：
  1.22±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  43.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-methyl-4-oxo-3,4-dihydrofuro[2,3-d]pyrimidine-5-carboxylic acid 、 (1-甲基-1H-吲唑-4-基)甲胺 在 2-氯-1,3-二甲基氯化咪唑啉 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以43 mg的产率得到6-methyl-N-((1-methyl-1H-indazol-4-yl)methyl)-4-oxo-3,4-dihydrofuro[2,3-d]pyrimidine-5-carboxamide
  参考文献：
  名称：

  [EN] COMPOUNDS AND USES THEREOF
  [FR] COMPOSÉS ET LEURS UTILISATIONS

  摘要：

  本发明涉及在治疗腺苷或腺苷受体相关疾病中有用的化合物。

  公开号：

  WO2020106625A1
• 作为产物：
  描述：

  1-甲基-1H-吲唑-4-羧酸 在 lithium aluminium tetrahydride 、 三乙胺 、 N,N'-羰基二咪唑 作用下， 以 四氢呋喃 、 1,4-二氧六环 为溶剂， 反应 2.17h， 生成 (1-甲基-1H-吲唑-4-基)甲胺
  参考文献：
  名称：

  [EN] COMPOUNDS AND USES THEREOF
  [FR] COMPOSÉS ET LEURS UTILISATIONS

  摘要：

  本发明涉及在治疗腺苷或腺苷受体相关疾病中有用的化合物。

  公开号：

  WO2020106625A1

文献信息

• Pyrazolo-triazine derivatives as selective cyclin-dependent kinase inhinitors
  申请人：Lead Discovery Center GmbH

  公开号：EP2634190A1

  公开（公告）日：2013-09-04

  The present invention relates to pyrazolo[1,5-a][1,3,5]triazine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, immunological diseases, autoimmune diseases, cardiovascular diseases, cell proliferative diseases, inflammation, erectile dysfunction and stroke, and pharmaceutical compositions containing at least one of said pyrazolo[1,5-a][1,3,5]triazine derivatives and/or pharmaceutically acceptable salts thereof. Furthermore, the present invention relates to the use of said pyrazolo[1,5-a][1,3,5]triazine derivatives as inhibitors for a protein kinase.

  本发明涉及吡唑并[1,5-a][1,3,5]三嗪衍生物和/或其药用可接受盐，以及这些衍生物作为药用活性剂的用途，特别是用于预防和/或治疗传染病，包括机会性疾病、免疫疾病、自身免疫疾病、心血管疾病、细胞增殖性疾病、炎症、勃起功能障碍和中风，以及含有至少一种所述吡唑并[1,5-a][1,3,5]三嗪衍生物和/或其药用可接受盐的药物组合物。此外，本发明涉及将所述吡唑并[1,5-a][1,3,5]三嗪衍生物用作蛋白激酶的抑制剂。
• NOVEL COMPOUNDS OF REVERSE TURN MIMETICS AND THE USE THEREOF (1)
  申请人：Choongwae Pharma Corporation

  公开号：EP2212329A2

  公开（公告）日：2010-08-04
• PYRAZOLO-TRIAZINE DERIVATIVES AS SELECTIVE CYCLIN-DEPENDENT KINASE INHIBITORS
  申请人：Lead Discovery Center GmbH

  公开号：EP2820020B1

  公开（公告）日：2016-04-06
• [EN] NOVEL COMPOUNDS OF REVERSE TURN MIMETICS AND THE USE THEREOF (1)<br/>[FR] NOUVEAUX COMPOSÉS DE STRUCTURES MIMÉTIQUES DE COUDE INVERSE ET LEUR UTILISATION (1)
  申请人：CHOONGWAE PHARMA CORP

  公开号：WO2009051399A2

  公开（公告）日：2009-04-23

  Conformationally constrained compounds that are novel and mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins and having bicyclic framework are disclosed, as well as derivatives thereof including prodrugs. Such reverse-turn mimetic structures and prodrugs have utility over a wide range of fields, including use as diagnostic and therapeutic agents. The invention also relates to a use of such compounds for the preparation of a medicament for treating or preventing cancer including an acute myeloid leukemia.
• [EN] PYRAZOLO - TRIAZINE DERIVATIVES AS SELECTIVE CYCLIN- DEPENDENT KINASE INHINITORS<br/>[FR] DÉRIVÉS PYRAZOLO-TRIAZINE UTILES EN TANT QU'INHIBITEURS DES KINASES DÉPENDANT DES CYCLINES
  申请人：LEAD DISCOVERY CENTER GMBH

  公开号：WO2013128028A1

  公开（公告）日：2013-09-06

  The present invention relates to pyrazolo[1,5-a][1,3,5]triazine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, immunological diseases, autoimmune diseases, cardiovascular diseases, cell proliferative diseases, inflammation, erectile dysfunction and stroke, and pharmaceutical compositions containing at least one of said pyrazolo[1,5-a][1,3,5]triazine derivatives and/or pharmaceutically acceptable salts thereof. Furthermore, the present invention relates to the use of said pyrazolo[1,5-a][1,3,5]triazine derivatives as inhibitors for a protein kinase.